| UniProt ID | PPR36_HUMAN | |
|---|---|---|
| UniProt AC | Q96LQ0 | |
| Protein Name | Protein phosphatase 1 regulatory subunit 36 | |
| Gene Name | PPP1R36 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 422 | |
| Subcellular Localization | ||
| Protein Description | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.. | |
| Protein Sequence | MYRVPEFYARRKRLGGQTPYLMDQLGLRLGMWYWKDETRTLEFRRFAAEDSVQWLLKHHPHFTPAAEVKEKGKKGKAVHFAETDGPASDRLTDKRLAAKDDKSAKAVEKRGQQGTITLDDVKFVTLLLLQDTEMQRICSFTTFMRNKNLDNFLMALLYYLSHYLEKNSLEKKPKSYMVGLVEKKEMELVLSELEAAQRYLAQKYCILVLGLAVPDKHHMCCGKEKISDTQKDWKFFESFYTFCTYVAWIVFRRQHLTEIEEEVGRLFRTNMFNIPRRRREDEESGGEKKRMTFVQFRRMMAKRPAIKKAINMRSPVMSTLLPSLREKAQNVFEKKYHQVDVRFPAEMQKHVGTLDSVPMPVVGILGEPRCLFNPHTLHPLDPEENTKSFGRYPSLMENNNMRIQDTLDLVMKTLSSHTSCPK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MYRVPEFYARRKRLG CCCCCHHHHHHHHHC | 9.50 | - | |
| 176 | Phosphorylation | LEKKPKSYMVGLVEK CCCCCCCCEEEECCH | 11.27 | 30576142 | |
| 191 | Phosphorylation | KEMELVLSELEAAQR HHHHHHHHHHHHHHH | 32.43 | 22798277 | |
| 199 | Phosphorylation | ELEAAQRYLAQKYCI HHHHHHHHHHHHHHH | 8.36 | - | |
| 269 | Phosphorylation | EVGRLFRTNMFNIPR HHHHHHHHCCCCCCC | 24.57 | - | |
| 292 | Phosphorylation | GGEKKRMTFVQFRRM CCHHHCHHHHHHHHH | 25.37 | 22210691 | |
| 302 | Acetylation | QFRRMMAKRPAIKKA HHHHHHHHCHHHHHH | 40.81 | 7681399 | |
| 314 | Phosphorylation | KKAINMRSPVMSTLL HHHHHCCCHHHHHHH | 15.86 | 30624053 | |
| 319 | Phosphorylation | MRSPVMSTLLPSLRE CCCHHHHHHHHHHHH | 17.76 | - | |
| 323 | Phosphorylation | VMSTLLPSLREKAQN HHHHHHHHHHHHHHH | 39.77 | 24719451 | |
| 388 | Phosphorylation | DPEENTKSFGRYPSL CHHHCCCCCCCCCHH | 30.78 | 22817900 | |
| 392 | Phosphorylation | NTKSFGRYPSLMENN CCCCCCCCCHHHHCC | 9.50 | 22817900 | |
| 413 | Phosphorylation | TLDLVMKTLSSHTSC HHHHHHHHHHHCCCC | 17.49 | 22817900 | |
| 418 | Phosphorylation | MKTLSSHTSCPK--- HHHHHHCCCCCC--- | 33.69 | 17287340 | |
| 419 | Phosphorylation | KTLSSHTSCPK---- HHHHHCCCCCC---- | 24.01 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PPR36_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PPR36_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PPR36_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PPR36_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-388; TYR-392; THR-413AND THR-418, AND MASS SPECTROMETRY. | |
