PPR29_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPR29_HUMAN
• UniProt AC: Q5R3F8
• Protein Name: Protein phosphatase 1 regulatory subunit 29
• Gene Name: ELFN2
• Organism: Homo sapiens (Human).
• Sequence Length: 820
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Description: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes..
• Protein Sequence: MLRLGLCAAALLCVCRPGAVRADCWLIEGDKGYVWLAICSQNQPPYETIPQHINSTVHDLRLNENKLKAVLYSSLNRFGNLTDLNLTKNEISYIEDGAFLGQSSLQVLQLGYNKLSNLTEGMLRGMSRLQFLFVQHNLIEVVTPTAFSECPSLISIDLSSNRLSRLDGATFASLASLMVCELAGNPFNCECDLFGFLAWLVVFNNVTKNYDRLQCESPREFAGYPLLVPRPYHSLNAITVLQAKCRNGSLPARPVSHPTPYSTDAQREPDENSGFNPDEILSVEPPASSTTDASAGPAIKLHHVTFTSATLVVIIPHPYSKMYILVQYNNSYFSDVMTLKNKKEIVTLDKLRAHTEYTFCVTSLRNSRRFNHTCLTFTTRDPVPGDLAPSTSTTTHYIMTILGCLFGMVIVLGAVYYCLRKRRMQEEKQKSVNVKKTILEMRYGADVDAGSIVHAAQKLGEPPVLPVSRMASIPSMIGEKLPTAKGLEAGLDTPKVATKGNYIEVRTGAGGDGLARPEDDLPDLENGQGSAAEISTIAKEVDKVNQIINNCIDALKLDSASFLGGGSSSGDPELAFECQSLPAAAAASSATGPGALERPSFLSPPYKESSHHPLQRQLSADAAVTRKTCSVSSSGSIKSAKVFSLDVPDHPAATGLAKGDSKYIEKGSPLNSPLDRLPLVPAGSGGGSGGGGGIHHLEVKPAYHCSEHRHSFPALYYEEGADSLSQRVSFLKPLTRSKRDSTYSQLSPRHYYSGYSSSPEYSSESTHKIWERFRPYKKHHREEVYMAAGHALRKKVQFAKDEDLHDILDYWKGVSAQQKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	N-linked_Glycosylation	ETIPQHINSTVHDLR CCCCHHHHHHHHHHC	29.51	UniProtKB CARBOHYD
80	N-linked_Glycosylation	SSLNRFGNLTDLNLT HHHHHCCCCCCCCCC	36.74	UniProtKB CARBOHYD
85	N-linked_Glycosylation	FGNLTDLNLTKNEIS CCCCCCCCCCCCCCE	48.77	UniProtKB CARBOHYD
117	N-linked_Glycosylation	LGYNKLSNLTEGMLR HCHHHHHCCCHHHHH	62.51	UniProtKB CARBOHYD
119	Phosphorylation	YNKLSNLTEGMLRGM HHHHHCCCHHHHHHH	34.44	29449344
127	Phosphorylation	EGMLRGMSRLQFLFV HHHHHHHHHHHHHHH	32.44	29449344
155	Phosphorylation	SECPSLISIDLSSNR HHCCCEEEEECCCCC	18.49	25332170
159	Phosphorylation	SLISIDLSSNRLSRL CEEEEECCCCCHHHC	23.09	25332170
205	N-linked_Glycosylation	AWLVVFNNVTKNYDR HHHHHHCCCCCCCCC	31.22	UniProtKB CARBOHYD
210	Phosphorylation	FNNVTKNYDRLQCES HCCCCCCCCCCCCCC	12.19	-
224	Phosphorylation	SPREFAGYPLLVPRP CCHHHCCCCEEECCC	6.30	-
232	Phosphorylation	PLLVPRPYHSLNAIT CEEECCCCCCCCHHH	12.81	-
247	N-linked_Glycosylation	VLQAKCRNGSLPARP HHHHHHCCCCCCCCC	54.60	UniProtKB CARBOHYD
249	Phosphorylation	QAKCRNGSLPARPVS HHHHCCCCCCCCCCC	34.43	24719451
307	Phosphorylation	KLHHVTFTSATLVVI EEEEEEEEEEEEEEE	14.21	-
421	Acetylation	AVYYCLRKRRMQEEK HHHHHHHHHHHHHHH	31.26	12636177
428	Acetylation	KRRMQEEKQKSVNVK HHHHHHHHHHCCCHH	63.37	12636189
430	Acetylation	RMQEEKQKSVNVKKT HHHHHHHHCCCHHHH	68.39	12636201
435	Ubiquitination	KQKSVNVKKTILEMR HHHCCCHHHHHHHHC	38.71	27667366
435	Acetylation	KQKSVNVKKTILEMR HHHCCCHHHHHHHHC	38.71	12636213
451	Phosphorylation	GADVDAGSIVHAAQK CCCCCHHHHHHHHHH	24.13	30266825
458	Ubiquitination	SIVHAAQKLGEPPVL HHHHHHHHHCCCCCC	54.45	21906983
468	Phosphorylation	EPPVLPVSRMASIPS CCCCCCHHHHCCCCH	17.88	26074081
472	Phosphorylation	LPVSRMASIPSMIGE CCHHHHCCCCHHHCC	26.20	30266825
475	Phosphorylation	SRMASIPSMIGEKLP HHHCCCCHHHCCCCC	22.74	30266825
480	Ubiquitination	IPSMIGEKLPTAKGL CCHHHCCCCCCCCHH	55.33	23000965
483	Phosphorylation	MIGEKLPTAKGLEAG HHCCCCCCCCHHHCC	51.98	24719451
485	Ubiquitination	GEKLPTAKGLEAGLD CCCCCCCCHHHCCCC	67.51	23000965
493	Phosphorylation	GLEAGLDTPKVATKG HHHCCCCCCCCCCCC	30.01	30266825
495	Ubiquitination	EAGLDTPKVATKGNY HCCCCCCCCCCCCCE	46.74	22817900
499	Ubiquitination	DTPKVATKGNYIEVR CCCCCCCCCCEEEEE	35.11	27667366
502	Phosphorylation	KVATKGNYIEVRTGA CCCCCCCEEEEECCC	13.71	19060867
530	Phosphorylation	DLENGQGSAAEISTI CCCCCCCCHHHHHHH	19.20	30266825
535	Phosphorylation	QGSAAEISTIAKEVD CCCHHHHHHHHHHHH	12.79	30266825
536	Phosphorylation	GSAAEISTIAKEVDK CCHHHHHHHHHHHHH	30.52	20639409
603	Phosphorylation	LERPSFLSPPYKESS HCCCHHCCCCCCCCC	23.09	23312004
606	Phosphorylation	PSFLSPPYKESSHHP CHHCCCCCCCCCCCH	30.67	17929957
610	Phosphorylation	SPPYKESSHHPLQRQ CCCCCCCCCCHHHHH	27.23	17929957
619	Phosphorylation	HPLQRQLSADAAVTR CHHHHHHCCCHHHCC	18.76	30266825
625	Phosphorylation	LSADAAVTRKTCSVS HCCCHHHCCCCCEEC	23.01	28102081
628	Phosphorylation	DAAVTRKTCSVSSSG CHHHCCCCCEECCCC	13.51	28985074
630	Phosphorylation	AVTRKTCSVSSSGSI HHCCCCCEECCCCCC	30.20	23090842
632	Phosphorylation	TRKTCSVSSSGSIKS CCCCCEECCCCCCCE	11.51	23090842
633	Phosphorylation	RKTCSVSSSGSIKSA CCCCEECCCCCCCEE	36.24	23090842
634	Phosphorylation	KTCSVSSSGSIKSAK CCCEECCCCCCCEEE	29.11	23090842
636	Phosphorylation	CSVSSSGSIKSAKVF CEECCCCCCCEEEEE	28.88	28985074
639	Phosphorylation	SSSGSIKSAKVFSLD CCCCCCCEEEEEEEC	31.49	21712546
644	Phosphorylation	IKSAKVFSLDVPDHP CCEEEEEEECCCCCC	27.01	30266825
654	Phosphorylation	VPDHPAATGLAKGDS CCCCCHHCCCCCCCH	34.53	22210691
661	Phosphorylation	TGLAKGDSKYIEKGS CCCCCCCHHHCCCCC	35.71	22210691
663	Phosphorylation	LAKGDSKYIEKGSPL CCCCCHHHCCCCCCC	20.47	23312004
668	Phosphorylation	SKYIEKGSPLNSPLD HHHCCCCCCCCCCHH	36.96	30266825
672	Phosphorylation	EKGSPLNSPLDRLPL CCCCCCCCCHHCCCC	34.23	30266825
711	Phosphorylation	HCSEHRHSFPALYYE CCCCCCCCCCEEECC	32.64	28985074
716	Phosphorylation	RHSFPALYYEEGADS CCCCCEEECCCCCCC	15.78	21945579
717	Phosphorylation	HSFPALYYEEGADSL CCCCEEECCCCCCCH	14.35	21945579
729	Phosphorylation	DSLSQRVSFLKPLTR CCHHHHHHHHHCCCC	27.35	24719451
735	Phosphorylation	VSFLKPLTRSKRDST HHHHHCCCCCCCCCC	41.23	30257219
737	Phosphorylation	FLKPLTRSKRDSTYS HHHCCCCCCCCCCCC	27.14	30257219
741	Phosphorylation	LTRSKRDSTYSQLSP CCCCCCCCCCCCCCC	33.02	28152594
742	Phosphorylation	TRSKRDSTYSQLSPR CCCCCCCCCCCCCCC	31.33	28152594
743	Phosphorylation	RSKRDSTYSQLSPRH CCCCCCCCCCCCCCC	9.81	28152594
744	Phosphorylation	SKRDSTYSQLSPRHY CCCCCCCCCCCCCCC	25.41	28152594
747	Phosphorylation	DSTYSQLSPRHYYSG CCCCCCCCCCCCCCC	16.55	28152594
751	Phosphorylation	SQLSPRHYYSGYSSS CCCCCCCCCCCCCCC	10.70	21945579
752	Phosphorylation	QLSPRHYYSGYSSSP CCCCCCCCCCCCCCC	6.90	21945579
753	Phosphorylation	LSPRHYYSGYSSSPE CCCCCCCCCCCCCCC	24.88	21945579
755	Phosphorylation	PRHYYSGYSSSPEYS CCCCCCCCCCCCCCC	10.23	21945579
756	Phosphorylation	RHYYSGYSSSPEYSS CCCCCCCCCCCCCCC	28.06	21945579
757	Phosphorylation	HYYSGYSSSPEYSSE CCCCCCCCCCCCCCH	41.24	21945579
758	Phosphorylation	YYSGYSSSPEYSSES CCCCCCCCCCCCCHH	18.79	21945579
761	Phosphorylation	GYSSSPEYSSESTHK CCCCCCCCCCHHHHH	22.38	-
785	Phosphorylation	KHHREEVYMAAGHAL HHCHHHHHHHHHHHH	5.59	27259358
810	Phosphorylation	DLHDILDYWKGVSAQ CHHHHHHHHHCCCHH	12.94	-
815	Phosphorylation	LDYWKGVSAQQKL-- HHHHHCCCHHHCC--	29.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPR29_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPR29_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPR29_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PPR29_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-619, AND MASSSPECTROMETRY.
PubMed: 17081983