PPK18_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPK18_SCHPO
• UniProt AC: Q8TFG6
• Protein Name: Serine/threonine-protein kinase ppk18
• Gene Name: ppk18
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1318
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MVMQERNSNEDNKVNHGIDNIYVLELDLDGSVLFASTNFSQITGISSLELTGKPAALLSSDQEIFNAAIEQLLDDDSHSVKIHTVISKLPSLEENVFVQDEEMELQSKSVELDCVGVLIRDPLTSRPSHTLWVLQPLKPTRITRQEIGQQLTETLGFGAQLLAQHLEKLQTVPSTDSLPPFETVLCRVCDHEIQNWYFEHHTELCLLIHHAEARAQEANDLLNEQRNALQSLLDSLDDQIEPDVSYLGVPLAAVLPSSITSSAKSNSRSSLSQKIRNYISNMLFDAISYTDSCLAIHLPFIPESTTREDNQPFSEIRLLSPASEVFNAKTLSWCLPHIDDPGLQLMFENTDALVKKKLDAINRLSNIIYYSERVRCEIEDQVQTIIEQSIQVDGYDEPLSTTTPTLIEPIQETLMTQSPIIECEPFNTVKPSVSPEEVHDISQFNHRNDPPITAASVDSSNSFSVHRSSTNHSSTNSGSPNLSRRNNLAIPIASRRKSVSAVNTLYGVGSSYTSESFPFSKLTVPVERNSFRETESPKPFLSRQIGISTLSSNISSGKGTPSIQDYEIIKPISKGTFGTVYLSRKNTTGEIYAIKVLRKVDMISKNQVANVKAERAVLMAQEESAFVAKLYYAFQSRDYLYLVMEFMNGGDCASLLKSLYTIPESWAKIYIAEVALGLEHLHRLGIIHRDIKPDNILMSITGHLKLADFGLSQLGLTTRQLRLQKGKNNILSPPSFQSPTALGDPGDNIASSPLILPTSVSAFSYDEKSQKQKTELATFTTYKEDDTTTTTRTSIDSISSKYLESPVDSQKVNRTPNLQSVPFFRQPDAPKRFVGTPDYLAPETLRGSTQDDMVDWWALGCVLFEFLFGYPPFHAETPEKVFENILANNIAWPDLEMYPCSEEALDLINGFLQPNPERRLGFSDINEIKEHPFFNGINWDDIFSHEAPFIPAPETPLDTAYFDSRGAGAAESNMSSSVNSGEEVSKDNNVSQERGSQFLRSSHGRSRERSTSARRSRRFSEANSEFDEFGPFSYKNLSVLERANRNAIEKIRSEIAGKLHISPPDPHIGYTPGSDMPSAKLYDQQLTLSPSLMTNQGSNFSSTDSTPRKSINSSDVESRSKTDGPKSMHDLIKQLHMRKHSSHTNQSTGSSESDDLFNLDLPISNLETSYPFKIEEGQASPLSSPLSKTPPFFSSSVPLKALICVSKLNLFSELIKLLKSYKFQVSIVTDEDKMLRTLMADEKFSIIFLQLDLTRVSGVSILKIVRSSNCANRNTPAIALTPTRIDINAAIPRMFDGRLYLPINAFLLRGYIARLCNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
320	Phosphorylation	FSEIRLLSPASEVFN CCCEEEECCHHHHHC	24.02	28889911
323	Phosphorylation	IRLLSPASEVFNAKT EEEECCHHHHHCCCC	37.36	25720772
456	Phosphorylation	DPPITAASVDSSNSF CCCCCEEEECCCCCE	24.80	25720772
459	Phosphorylation	ITAASVDSSNSFSVH CCEEEECCCCCEEEE	29.30	25720772
460	Phosphorylation	TAASVDSSNSFSVHR CEEEECCCCCEEEEE	31.84	25720772
462	Phosphorylation	ASVDSSNSFSVHRSS EEECCCCCEEEEECC	22.35	25720772
464	Phosphorylation	VDSSNSFSVHRSSTN ECCCCCEEEEECCCC	19.48	25720772
470	Phosphorylation	FSVHRSSTNHSSTNS EEEEECCCCCCCCCC	37.89	29996109
474	Phosphorylation	RSSTNHSSTNSGSPN ECCCCCCCCCCCCCC	24.85	29996109
477	Phosphorylation	TNHSSTNSGSPNLSR CCCCCCCCCCCCCCH	40.51	29996109
479	Phosphorylation	HSSTNSGSPNLSRRN CCCCCCCCCCCCHHC	15.50	28889911
483	Phosphorylation	NSGSPNLSRRNNLAI CCCCCCCCHHCCCEE	35.52	25720772
498	Phosphorylation	PIASRRKSVSAVNTL ECCCCCCCHHHHHCC	21.35	25720772
530	Phosphorylation	TVPVERNSFRETESP EEEECCCCCCCCCCC	31.72	29996109
534	Phosphorylation	ERNSFRETESPKPFL CCCCCCCCCCCCCCH	37.19	29996109
536	Phosphorylation	NSFRETESPKPFLSR CCCCCCCCCCCCHHH	45.72	28889911
793	Phosphorylation	DTTTTTRTSIDSISS CCCCEEEHHHHHHHH	28.13	24763107
794	Phosphorylation	TTTTTRTSIDSISSK CCCEEEHHHHHHHHH	22.55	28889911
797	Phosphorylation	TTRTSIDSISSKYLE EEEHHHHHHHHHHCC	23.77	28889911
805	Phosphorylation	ISSKYLESPVDSQKV HHHHHCCCCCCCCCC	27.85	24763107
972	Phosphorylation	RGAGAAESNMSSSVN CCCCCCHHCCCCCCC	32.86	25720772
975	Phosphorylation	GAAESNMSSSVNSGE CCCHHCCCCCCCCCC	24.58	25720772
976	Phosphorylation	AAESNMSSSVNSGEE CCHHCCCCCCCCCCC	27.77	25720772
977	Phosphorylation	AESNMSSSVNSGEEV CHHCCCCCCCCCCCC	20.29	25720772
980	Phosphorylation	NMSSSVNSGEEVSKD CCCCCCCCCCCCCCC	45.48	25720772
1016	Phosphorylation	RSTSARRSRRFSEAN CCHHHHHHHHHHHHC	23.43	28889911
1020	Phosphorylation	ARRSRRFSEANSEFD HHHHHHHHHHCCCCC	33.71	25720772
1024	Phosphorylation	RRFSEANSEFDEFGP HHHHHHCCCCCCCCC	46.84	25720772
1062	Phosphorylation	IAGKLHISPPDPHIG HCCCCCCCCCCCCCC	21.45	28889911
1070	Phosphorylation	PPDPHIGYTPGSDMP CCCCCCCCCCCCCCC	14.79	21712547
1071	Phosphorylation	PDPHIGYTPGSDMPS CCCCCCCCCCCCCCC	18.89	21712547
1074	Phosphorylation	HIGYTPGSDMPSAKL CCCCCCCCCCCCCCH	31.75	24763107
1110	Phosphorylation	TDSTPRKSINSSDVE CCCCCCCCCCHHHCC	28.43	24763107
1114	Phosphorylation	PRKSINSSDVESRSK CCCCCCHHHCCHHHC	40.98	21712547
1180	Phosphorylation	KIEEGQASPLSSPLS EEECCCCCCCCCCCC	20.63	28889911
1183	Phosphorylation	EGQASPLSSPLSKTP CCCCCCCCCCCCCCC	33.04	25720772
1184	Phosphorylation	GQASPLSSPLSKTPP CCCCCCCCCCCCCCC	37.23	24763107
1187	Phosphorylation	SPLSSPLSKTPPFFS CCCCCCCCCCCCCCC	37.56	25720772
1189	Phosphorylation	LSSPLSKTPPFFSSS CCCCCCCCCCCCCCC	32.58	28889911
1257	Phosphorylation	QLDLTRVSGVSILKI ECCCCCCCCEEHHHH	30.13	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPK18_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPK18_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPK18_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of PPK18_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.