PPCS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPCS_HUMAN
• UniProt AC: Q9HAB8
• Protein Name: Phosphopantothenate--cysteine ligase
• Gene Name: PPCS
• Organism: Homo sapiens (Human).
• Sequence Length: 311
• Protein Description: Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine..
• Protein Sequence: MAEMDPVAEFPQPPGAARWAEVMARFAARLGAQGRRVVLVTSGGTKVPLEARPVRFLDNFSSGRRGATSAEAFLAAGYGVLFLYRARSAFPYAHRFPPQTWLSALRPSGPALSGLLSLEAEENALPGFAEALRSYQEAAAAGTFLAVEFTTLADYLHLLQAAAQALNPLGPSAMFYLAAAVSDFYVPVSEMPEHKIQSSGGPLQITMKMVPKLLSPLVKDWAPKAFIISFKLETDPAIVINRARKALEIYQHQVVVANILESRQSFVFIVTKDSETKLLLSEEEIEKGVEIEEKIVDNLQSRHTAFIGDRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEMDPVAE ------CCCCCCCCC	22.33	22223895
13	Ubiquitination	PVAEFPQPPGAARWA CCCCCCCCCCHHHHH	29.54	22817900
18	Ubiquitination	PQPPGAARWAEVMAR CCCCCHHHHHHHHHH	32.38	21890473
41	Phosphorylation	GRRVVLVTSGGTKVP CCEEEEEECCCCCCC	19.93	20068231
42	Phosphorylation	RRVVLVTSGGTKVPL CEEEEEECCCCCCCC	27.96	22817901
45	Phosphorylation	VLVTSGGTKVPLEAR EEEECCCCCCCCCCC	32.18	20068231
46	Ubiquitination	LVTSGGTKVPLEARP EEECCCCCCCCCCCC	45.17	23000965
51	Ubiquitination	GTKVPLEARPVRFLD CCCCCCCCCCEEECC	28.85	21890473
51	Ubiquitination	GTKVPLEARPVRFLD CCCCCCCCCCEEECC	28.85	21890473
71	Ubiquitination	RRGATSAEAFLAAGY CCCCCHHHHHHHHCC	39.46	29967540
81	Ubiquitination	LAAGYGVLFLYRARS HHHCCHHHHHHHHHH	1.81	29967540
88	Ubiquitination	LFLYRARSAFPYAHR HHHHHHHHCCCCCCC	33.02	29967540
104	Ubiquitination	PPQTWLSALRPSGPA CCHHHHHHCCCCCCC	12.86	29967540
114	Ubiquitination	PSGPALSGLLSLEAE CCCCCHHHHCCHHHH	31.33	29967540
121	Ubiquitination	GLLSLEAEENALPGF HHCCHHHHHCCCHHH	42.27	29967540
198	Phosphorylation	MPEHKIQSSGGPLQI CCCCCCCCCCCCCCH	34.13	25159151
199	Phosphorylation	PEHKIQSSGGPLQIT CCCCCCCCCCCCCHH	31.24	28857561
206	Phosphorylation	SGGPLQITMKMVPKL CCCCCCHHEEHHHHH	9.59	28857561
212	Acetylation	ITMKMVPKLLSPLVK HHEEHHHHHHHHHHC	51.12	25953088
215	Phosphorylation	KMVPKLLSPLVKDWA EHHHHHHHHHHCCCC	26.99	24719451
219	Ubiquitination	KLLSPLVKDWAPKAF HHHHHHHCCCCCCEE	56.06	22817900
224	Ubiquitination	LVKDWAPKAFIISFK HHCCCCCCEEEEEEE	48.45	22817900
229	Phosphorylation	APKAFIISFKLETDP CCCEEEEEEECCCCH	16.12	17322306
277	Ubiquitination	VTKDSETKLLLSEEE EECCCCCEEEECHHH	32.84	29967540
281	Phosphorylation	SETKLLLSEEEIEKG CCCEEEECHHHHHHC	42.82	-
287	Ubiquitination	LSEEEIEKGVEIEEK ECHHHHHHCCCHHHH	74.12	29967540
294	Ubiquitination	KGVEIEEKIVDNLQS HCCCHHHHHHHHHHH	34.93	29967540
301	Phosphorylation	KIVDNLQSRHTAFIG HHHHHHHHCCCEECC	29.24	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPCS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPCS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPCS_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PPCS_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.