UniProt ID | PPCEL_MOUSE | |
---|---|---|
UniProt AC | Q8C167 | |
Protein Name | Prolyl endopeptidase-like | |
Gene Name | Prepl | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 725 | |
Subcellular Localization | Cytoplasm, cytosol . | |
Protein Description | Probable serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. May play a role in the regulation of synaptic vesiscle exocytosis.. | |
Protein Sequence | MLQTAKFSLRALKHSIPHLGNCMQKQSYRNVAGPYYSRVRLKKYHLTKCLQNKPRIAGLARNIPSRSFSCKDLLPIKPESEKPISENMDAFEKVRTRLETQPQEEYEVVNAEIKHGGFVYYQEGCCLVRSKDEEADSDNYEVLFNLEELKLDQPFIDCIRVAPDEKYVAAKIRTEDSETSTLVVVKLSDQPVMEASFPNVSSFEWVKDEEDEDVLFYTFQRNLRCHDVYRATFGDNKRNERFYTEKDPSYFVFLYLTKDSRFLTLNIMNKTTSEVWLIDGLSPWDPPVLIQKRIHGMLYYVEHRDDELYILTNVGEPTEFKLMRTAADAPAIMNWDLFFTMKRNTKVVDLDMFKDHCVLFLKHSNLLYVNVIGLADDSVRSLKLPPWACGFIMDTNSDPKNCPFQLCSPIRPPKYYTYKFAEGKLFEETGHEDPITKTSRVLRIEAKSKDGKLVPMTVFHKTDSEDLQRKPLLVHVYGAYGMDLKMNFRPEKRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNGLADLVACIKTLHSQGFSQPSLTTLSAFSAGGVLVGALCNSKPELLRAVTLEAPFLDVLNTMLDTTLPLTLEELEEWGNPSSDEKHKNYIKRYCPCQNIKPQHYPSVHITAYENDERVPLKGIVNYTEKLKEAVAEHTKGAGEGYQPPNIILDIQPGGNHVIEDSHKKITTQMKFLYEELGLDSTDAFEALKKYLKF | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
6 (in isoform 2) | Ubiquitination | - | 38.58 | - | |
35 | Phosphorylation | YRNVAGPYYSRVRLK HHCCCCCCHHHHHHH | 17.10 | 22817900 | |
44 (in isoform 2) | Ubiquitination | - | 10.65 | - | |
93 (in isoform 2) | Ubiquitination | - | 30.48 | 22790023 | |
93 | Ubiquitination | ENMDAFEKVRTRLET CCHHHHHHHHHHHHC | 30.48 | 22790023 | |
130 | Phosphorylation | EGCCLVRSKDEEADS CCEEEEEECCCCCCC | 36.66 | 24925903 | |
131 (in isoform 2) | Ubiquitination | - | 59.60 | 22790023 | |
131 | Ubiquitination | GCCLVRSKDEEADSD CEEEEEECCCCCCCC | 59.60 | 22790023 | |
137 | Phosphorylation | SKDEEADSDNYEVLF ECCCCCCCCCEEEEE | 34.50 | 24925903 | |
140 | Phosphorylation | EEADSDNYEVLFNLE CCCCCCCEEEEEEHH | 16.65 | 22324799 | |
171 | Ubiquitination | DEKYVAAKIRTEDSE CCCEEEEEEECCCCC | 24.00 | - | |
177 | Phosphorylation | AKIRTEDSETSTLVV EEEECCCCCCEEEEE | 36.22 | 22006019 | |
324 | Methylation | PTEFKLMRTAADAPA CCCEECCCHHCCCCC | 31.48 | 16288521 | |
337 (in isoform 2) | Ubiquitination | - | 2.62 | - | |
350 (in isoform 2) | Ubiquitination | - | 3.30 | - | |
418 | Phosphorylation | RPPKYYTYKFAEGKL CCCCEEEEEEECCCE | 6.49 | 28576409 | |
424 (in isoform 2) | Ubiquitination | - | 41.32 | 22790023 | |
424 | Ubiquitination | TYKFAEGKLFEETGH EEEEECCCEECCCCC | 41.32 | 22790023 | |
437 | Ubiquitination | GHEDPITKTSRVLRI CCCCCCCCCEEEEEE | 45.26 | 22790023 | |
437 (in isoform 2) | Ubiquitination | - | 45.26 | 22790023 | |
438 | Phosphorylation | HEDPITKTSRVLRIE CCCCCCCCEEEEEEE | 17.08 | 24759943 | |
439 | Phosphorylation | EDPITKTSRVLRIEA CCCCCCCEEEEEEEE | 23.19 | 24759943 | |
633 (in isoform 2) | Ubiquitination | - | 27.96 | - | |
720 | Ubiquitination | TDAFEALKKYLKF-- CHHHHHHHHHHCC-- | 46.55 | 22790023 | |
720 (in isoform 2) | Ubiquitination | - | 46.55 | 22790023 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PPCEL_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PPCEL_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PPCEL_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of PPCEL_MOUSE !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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