PPCEL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPCEL_MOUSE
• UniProt AC: Q8C167
• Protein Name: Prolyl endopeptidase-like
• Gene Name: Prepl
• Organism: Mus musculus (Mouse).
• Sequence Length: 725
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Probable serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. May play a role in the regulation of synaptic vesiscle exocytosis..
• Protein Sequence: MLQTAKFSLRALKHSIPHLGNCMQKQSYRNVAGPYYSRVRLKKYHLTKCLQNKPRIAGLARNIPSRSFSCKDLLPIKPESEKPISENMDAFEKVRTRLETQPQEEYEVVNAEIKHGGFVYYQEGCCLVRSKDEEADSDNYEVLFNLEELKLDQPFIDCIRVAPDEKYVAAKIRTEDSETSTLVVVKLSDQPVMEASFPNVSSFEWVKDEEDEDVLFYTFQRNLRCHDVYRATFGDNKRNERFYTEKDPSYFVFLYLTKDSRFLTLNIMNKTTSEVWLIDGLSPWDPPVLIQKRIHGMLYYVEHRDDELYILTNVGEPTEFKLMRTAADAPAIMNWDLFFTMKRNTKVVDLDMFKDHCVLFLKHSNLLYVNVIGLADDSVRSLKLPPWACGFIMDTNSDPKNCPFQLCSPIRPPKYYTYKFAEGKLFEETGHEDPITKTSRVLRIEAKSKDGKLVPMTVFHKTDSEDLQRKPLLVHVYGAYGMDLKMNFRPEKRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNGLADLVACIKTLHSQGFSQPSLTTLSAFSAGGVLVGALCNSKPELLRAVTLEAPFLDVLNTMLDTTLPLTLEELEEWGNPSSDEKHKNYIKRYCPCQNIKPQHYPSVHITAYENDERVPLKGIVNYTEKLKEAVAEHTKGAGEGYQPPNIILDIQPGGNHVIEDSHKKITTQMKFLYEELGLDSTDAFEALKKYLKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6 (in isoform 2)	Ubiquitination	-	38.58	-
35	Phosphorylation	YRNVAGPYYSRVRLK HHCCCCCCHHHHHHH	17.10	22817900
44 (in isoform 2)	Ubiquitination	-	10.65	-
93 (in isoform 2)	Ubiquitination	-	30.48	22790023
93	Ubiquitination	ENMDAFEKVRTRLET CCHHHHHHHHHHHHC	30.48	22790023
130	Phosphorylation	EGCCLVRSKDEEADS CCEEEEEECCCCCCC	36.66	24925903
131 (in isoform 2)	Ubiquitination	-	59.60	22790023
131	Ubiquitination	GCCLVRSKDEEADSD CEEEEEECCCCCCCC	59.60	22790023
137	Phosphorylation	SKDEEADSDNYEVLF ECCCCCCCCCEEEEE	34.50	24925903
140	Phosphorylation	EEADSDNYEVLFNLE CCCCCCCEEEEEEHH	16.65	22324799
171	Ubiquitination	DEKYVAAKIRTEDSE CCCEEEEEEECCCCC	24.00	-
177	Phosphorylation	AKIRTEDSETSTLVV EEEECCCCCCEEEEE	36.22	22006019
324	Methylation	PTEFKLMRTAADAPA CCCEECCCHHCCCCC	31.48	16288521
337 (in isoform 2)	Ubiquitination	-	2.62	-
350 (in isoform 2)	Ubiquitination	-	3.30	-
418	Phosphorylation	RPPKYYTYKFAEGKL CCCCEEEEEEECCCE	6.49	28576409
424 (in isoform 2)	Ubiquitination	-	41.32	22790023
424	Ubiquitination	TYKFAEGKLFEETGH EEEEECCCEECCCCC	41.32	22790023
437	Ubiquitination	GHEDPITKTSRVLRI CCCCCCCCCEEEEEE	45.26	22790023
437 (in isoform 2)	Ubiquitination	-	45.26	22790023
438	Phosphorylation	HEDPITKTSRVLRIE CCCCCCCCEEEEEEE	17.08	24759943
439	Phosphorylation	EDPITKTSRVLRIEA CCCCCCCEEEEEEEE	23.19	24759943
633 (in isoform 2)	Ubiquitination	-	27.96	-
720	Ubiquitination	TDAFEALKKYLKF-- CHHHHHHHHHHCC--	46.55	22790023
720 (in isoform 2)	Ubiquitination	-	46.55	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPCEL_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPCEL_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPCEL_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PPCEL_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.