PPBT_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPBT_MOUSE
• UniProt AC: P09242
• Protein Name: Alkaline phosphatase, tissue-nonspecific isozyme
• Gene Name: Alpl
• Organism: Mus musculus (Mouse).
• Sequence Length: 524
• Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor .
• Protein Description: This isozyme may play a role in skeletal mineralization..
• Protein Sequence: MISPFLVLAIGTCLTNSFVPEKERDPSYWRQQAQETLKNALKLQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNTGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKPRHKHSHYVWNRTELLALDPSRVDYLLGLFEPGDMQYELNRNNLTDPSLSEMVEVALRILTKNLKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGKAGAMTSQKDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVDGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYASCIGANLDHCAWAGSGSAPSPGALLLPLAVLSLRTLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Phosphorylation	GMGVSTVTAARILKG CCCHHHHHHHHHHCC	18.06	55241621
100	Phosphorylation	PFVALSKTYNTNAQV CEEEEECEECCCCCC	20.73	23984901
101	Phosphorylation	FVALSKTYNTNAQVP EEEEECEECCCCCCC	24.59	20415495
103	Phosphorylation	ALSKTYNTNAQVPDS EEECEECCCCCCCCC	22.86	23984901
110	Phosphorylation	TNAQVPDSAGTATAY CCCCCCCCCCCCEEE	23.64	27742792
113	Phosphorylation	QVPDSAGTATAYLCG CCCCCCCCCEEEEEE	22.13	23737553
115	Phosphorylation	PDSAGTATAYLCGVK CCCCCCCEEEEEEEE	18.70	26643407
117	Phosphorylation	SAGTATAYLCGVKAN CCCCCEEEEEEEECC	9.73	21183079
140	N-linked_Glycosylation	ATERTRCNTTQGNEV ECCCCCCCCCCCCHH	42.76	19349973
159	Acetylation	RWAKDAGKSVGIVTT HHHHHCCCEEEEEEE	43.63	21728379
230	N-linked_Glycosylation	RKYMYPKNRTDVEYE CCCCCCCCCCCCEEE	47.80	19349973
271	N-linked_Glycosylation	KHSHYVWNRTELLAL CCCCCCCCCHHEEEC	30.84	-
281	Phosphorylation	ELLALDPSRVDYLLG HEEECCHHHCHHHHC	44.60	28059163
303	N-linked_Glycosylation	QYELNRNNLTDPSLS HHHHHCCCCCCCCHH	40.87	19349973
361	Acetylation	EMDQAIGKAGAMTSQ HHHHHHHHHCCCCCC	37.22	7612913
394	Phosphorylation	GYTPRGNSIFGLAPM CEECCCCCCCEECCC	23.32	25195567
430	N-linked_Glycosylation	VVDGERENVSMVDYA EECCCCEEEEEEECC	37.07	19349973
439	N-linked_Glycosylation	SMVDYAHNNYQAQSA EEEECCCCCCCCCCC	40.51	19349973
501	GPI-anchor	LDHCAWAGSGSAPSP CCCCCCCCCCCCCCC	23.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPBT_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPBT_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPBT_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-140; ASN-230; ASN-303;ASN-430 AND ASN-439, AND MASS SPECTROMETRY.
PubMed: 19349973