PP4R4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PP4R4_HUMAN
• UniProt AC: Q6NUP7
• Protein Name: Serine/threonine-protein phosphatase 4 regulatory subunit 4
• Gene Name: PPP4R4
• Organism: Homo sapiens (Human).
• Sequence Length: 873
• Subcellular Localization: Cytoplasm .
• Protein Description: Putative regulatory subunit of serine/threonine-protein phosphatase 4..
• Protein Sequence: MHPPPPAAAMDFSQNSLFGYMEDLQELTIIERPVRRSLKTPEEIERLTVDEDLSDIERAVYLLSAGQDVQGTSVIANLPFLMRQNPTETLRRVLPKVREALHVAGVEMQLTAAMSFLTILQDESVSIHAYTHSFLQVILLHLEHRDTGVSNAWLETLLSVIEVLPKETLRHEILNPLVSKAQLSQTVQSRLVSCKILGKLTNKFDAHTIKREILPLVKSLCQDVEYEVRSCMCRQLENIAQGIGTELTKSVVLPELIELSRDEGSSVRLAAFETLVNLLDIFDTDDRSQTILPLVKSFCEKSFKADESILISLSFHLGKLCHGLYGIFTPDQHLRFLEFYKKLCTLGLQQENGHNENQIPPQILEQEKKYISVRKNCAYNFPAMIVFVDPKNFHMELYSTFFCLCHDPEVPVRYTIAICFYEVSKLLNSGVYLIHKELITLLQDESLEVLDALIDHLPEILELMSTGGESSVQENKLSSLPDLIPALTAAEQRAAASLKWRTHEKLLQKYACLPHVISSDQIYYRFLQRMFTIMMTNNVLPVQKAASRTLCIFLRYNRKQEQRHEVIQKLIEQLGQGKSYWNRLRFLDTCEFIIEIFSKSFFCKYFFLPAIELTHDPVANVRMKLCYLLPKVKSTLKIPADKHLLQQLEMCVRKLLCQEKDKDVLAIVKRTVLELDRMEMSMDAFQKKFYEKDLLDQEKEREELLLLEMEQLEKEKQQNDGRPMSDKMFEKKRRDTKTPTQSLPKNIPISVPGPSSVTPSTSKEIKKSKLIRSQSFNNQAFHAKYGNLEKCASKSSTTGYTTSVSGLGKTSVLSLADDSFRTRNASSVPSSFSPNTPLPSTSRGTGNSVDPKSSGSKDTQPRKATLKSRKSNP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	IERPVRRSLKTPEEI EECCCCCCCCCHHHH	24.53	18785766
589	Phosphorylation	NRLRFLDTCEFIIEI HHHHHHHHHHHHHHH	18.97	-
598	Phosphorylation	EFIIEIFSKSFFCKY HHHHHHHCHHHHHHH	32.81	24719451
600	Phosphorylation	IIEIFSKSFFCKYFF HHHHHCHHHHHHHCC	23.51	-
605	Phosphorylation	SKSFFCKYFFLPAIE CHHHHHHHCCCCCCC	10.76	-
687	Acetylation	MSMDAFQKKFYEKDL HCHHHHHHHHHHHHC	38.09	19815049
725	Phosphorylation	QNDGRPMSDKMFEKK HCCCCCCCHHHHHHH	36.44	29978859
736	Phosphorylation	FEKKRRDTKTPTQSL HHHHHCCCCCCCCCC	34.70	29083192
738	Phosphorylation	KKRRDTKTPTQSLPK HHHCCCCCCCCCCCC	33.39	29083192
740	Phosphorylation	RRDTKTPTQSLPKNI HCCCCCCCCCCCCCC	35.70	29083192
742	Phosphorylation	DTKTPTQSLPKNIPI CCCCCCCCCCCCCCC	49.47	22985185
755	Phosphorylation	PISVPGPSSVTPSTS CCCCCCCCCCCCCCC	43.27	-
756	Phosphorylation	ISVPGPSSVTPSTSK CCCCCCCCCCCCCCH	32.89	-
760	Phosphorylation	GPSSVTPSTSKEIKK CCCCCCCCCCHHHHH	35.63	-
761	Phosphorylation	PSSVTPSTSKEIKKS CCCCCCCCCHHHHHH	45.05	-
762	Phosphorylation	SSVTPSTSKEIKKSK CCCCCCCCHHHHHHH	32.40	-
768	Phosphorylation	TSKEIKKSKLIRSQS CCHHHHHHHCCCCCC	27.91	18452278
773	Phosphorylation	KKSKLIRSQSFNNQA HHHHCCCCCCCCCHH	24.15	30266825
775	Phosphorylation	SKLIRSQSFNNQAFH HHCCCCCCCCCHHHH	31.05	30266825
796	Phosphorylation	EKCASKSSTTGYTTS HHHHCCCCCCCCEEE	33.45	-
797	Phosphorylation	KCASKSSTTGYTTSV HHHCCCCCCCCEEEC	31.19	24719451
800	Phosphorylation	SKSSTTGYTTSVSGL CCCCCCCCEEECCCC	12.54	24719451
827	Phosphorylation	FRTRNASSVPSSFSP CCCCCCCCCCCCCCC	35.32	27251275
830	Phosphorylation	RNASSVPSSFSPNTP CCCCCCCCCCCCCCC	41.69	27251275
831	Phosphorylation	NASSVPSSFSPNTPL CCCCCCCCCCCCCCC	24.55	27251275
833	Phosphorylation	SSVPSSFSPNTPLPS CCCCCCCCCCCCCCC	21.13	27251275
848	Phosphorylation	TSRGTGNSVDPKSSG CCCCCCCCCCCCCCC	29.28	-
852	Acetylation	TGNSVDPKSSGSKDT CCCCCCCCCCCCCCC	53.44	20167786
853	Phosphorylation	GNSVDPKSSGSKDTQ CCCCCCCCCCCCCCC	45.37	24144214
854	Phosphorylation	NSVDPKSSGSKDTQP CCCCCCCCCCCCCCC	53.89	24144214
856	Phosphorylation	VDPKSSGSKDTQPRK CCCCCCCCCCCCCCC	29.34	24144214
857	Acetylation	DPKSSGSKDTQPRKA CCCCCCCCCCCCCCC	69.21	20167786
859	Phosphorylation	KSSGSKDTQPRKATL CCCCCCCCCCCCCCC	44.18	24144214

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PP4R4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PP4R4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PP4R4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PP4C_HUMAN	PPP4C	physical	18715871
PP4C_HUMAN	PPP4C	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.