POTE1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: POTE1_MOUSE
• UniProt AC: Q91WC1
• Protein Name: Protection of telomeres protein 1
• Gene Name: Pot1
• Organism: Mus musculus (Mouse).
• Sequence Length: 640
• Subcellular Localization: Nucleus. Chromosome, telomere. Colocalizes with telomeric DNA..
• Protein Description: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity (By similarity)..
• Protein Sequence: MSLVSTAPYTYTPLNLLKEGTIANVYGVVKFFKPPYVSKGTDYCSVVTIVDQTNVKLTCMLFSGNYEALPIIYKVGDIVRFHRLKIQVYKNELQGINCSGFASLTFEGTVGMPVTARTSSKVFSFTPQDQKMVEALRVWASKHISASSTLVQLCDAQPMQYYDLTCQLLGKAQVDSTAFLLKVWDGTQTVLPSWRVSTQDLTFEGDLSHIERLQSLVVDILVYDNHVQVARSIEVGCFLRLYSLHTKLQPGNSETSSSESLRLEFHLHGGTSYGRGIRVLPDTSPCVDQLKKALEGANLPVTETSTGICQSENGDSSALSNSGSGAVSPYEEERCQQVSATILTNHQHLEKTPLCAILTQKAPQQYRVRAKLRSYLPRRLSQSVKLLCPKCHSVQEVPHGDSLDKILQDAATEAPDIKLKATSLYYSKVWTTEDQGGRQVAVHFVKNNGILPASSECLILIEGGRLCEVSKLSSKFHSVMPVRSGPESLELLTLSAPFLIQGKVHHYGCKQCSSLKPIQNLNSRFHKGPWTPSSVAEALGVVPLQYVFVMVFTLDDGTGVLEAYLKDSEHFFKIPASEVLTDDDLQRSLETIMDMICPPGIKVDAYPWLECLLKSYNVTIGTERRICYQIFDTTVAENVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSLVSTAPYTYTP --CCCCCCCCCCCCC	24.95	26643407
9	Phosphorylation	SLVSTAPYTYTPLNL CCCCCCCCCCCCHHH	15.20	26643407
10	Phosphorylation	LVSTAPYTYTPLNLL CCCCCCCCCCCHHHH	21.62	26643407
11	Phosphorylation	VSTAPYTYTPLNLLK CCCCCCCCCCHHHHC	10.66	26643407
12	Phosphorylation	STAPYTYTPLNLLKE CCCCCCCCCHHHHCC	17.31	26643407
381	Phosphorylation	SYLPRRLSQSVKLLC HHCHHHHHHHHHHHC	20.71	28066266
383	Phosphorylation	LPRRLSQSVKLLCPK CHHHHHHHHHHHCCC	20.17	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of POTE1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of POTE1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of POTE1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of POTE1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.