PORED_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PORED_DROME
• UniProt AC: Q9VLP9
• Protein Name: Polyprenol reductase
• Gene Name: CG7840
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 326
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity)..
• Protein Sequence: MAPPENGILEVLENLLDRYKINLLQMMFGTFIATIVFFGGLMTFVEKYLPNSIRQSFRYGKHSFKGETDPLVAWLEVPKSWFKHFYTFALFWSWLAFYVLVSTVREQKEAPEYVLQFLDIMGGGRSHRKVEIDSTTACVGAFMLTLQCTRRFYETNFVQIFSKKSKINLSHYAVGYVHYFGAVIALLSNTSGFVRGSKPMEFSLDKLTSQQILYLGVFFLAWQQQYASNMILVNLRKDPRTGSVKTEKHLLPKGGLFNLLSSPHMFLEVVMYFCIADLYMPVRIWRLIFLWVASNQTINALLTHKWYQETFREYPKNRRAIIPFLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Phosphorylation	LPNSIRQSFRYGKHS CCHHHHHHHHHCCCC	11.22	22817900
59	Phosphorylation	SIRQSFRYGKHSFKG HHHHHHHHCCCCCCC	28.63	22817900
63	Phosphorylation	SFRYGKHSFKGETDP HHHHCCCCCCCCCCC	31.94	22817900
261	Phosphorylation	GGLFNLLSSPHMFLE CCHHHHHCCHHHHHH	45.02	23607784
262	Phosphorylation	GLFNLLSSPHMFLEV CHHHHHCCHHHHHHH	20.85	23607784
272	Phosphorylation	MFLEVVMYFCIADLY HHHHHHHHHHHHHHH	5.45	23607784
279	Phosphorylation	YFCIADLYMPVRIWR HHHHHHHHHHHHHHH	10.42	23607784

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PORED_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PORED_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PORED_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of PORED_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.