POF6_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: POF6_SCHPO
• UniProt AC: O74854
• Protein Name: F-box protein pof6
• Gene Name: pof6
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 872
• Subcellular Localization: Cytoplasm. Nucleus. Constantly expressed throughout the cell cycle. Expressed in nucleus except the nucleolus and is localized at cell tips on both sides of the septum in septated cells.
• Protein Description: Together with skp1, essential for septum processing and cell separation..
• Protein Sequence: MKPSEAREHAIRKIKEYLERRHKQQFKALFGCLTINIYLKIFTLISTPDLCNCRLVCRKFQQLCDYNSIYVKKLLLMNAWDVTLSRKLYYESQDGMSQANMSSNTSKGFHLQSSDKKYADSDRPKLSSSSLLSLPDQKIPFPVDYSTVQGKQVVLTVLDCVSQRVEFARLDYIKVWRALAPIYRNLAYASNTIDPIAFSAFRTPEEQSKVLKYLIRFGNSYPYGTYRQAMQNAILDMASLFEQACLDEFELGLHSRNLDLLRKFSHVLHDFSGPNAYVSMYLAKQTDFVRSFFHFDPYSLFISNNLEEIHINWNILESVVNDTIKLLESESKFSEATLPEPELVQVPYAKDILGNSLKDYVISICEHIGEEETELFLVFISGFYGLCKKFFSIPNGPALVDTIFQPQIDIFISQELHYFKTVGWSLVDQWDQKLEEKEDATECFFYKNVSQNTAKNNFLETFKNVMLLPVSLFTIPSENNSASNLAEKAIEQKEEEDPELSKLDAARFVPANIYVSKDRLKHLPTTELAAQAAVLDSKLEGISTMFSLELALKIVHLCKVSLARAKVFMGTSVPQDDDIKGLSKDLFVQLLRELGQGHLKHGFDRAIEHLSSFDPRRDFSSNTVEPVVKFLELINVGDMIQQMMDSFFNEEMSPICVKDDMFDPAIAEKKKFEQLLDERAAFGLHKGINVLIEHADFLLETKTPMNLFSDQTIGSITNTIEPTAAAKNVVQFLGFHMRILVGRADHEILDVFYKEVGMRLFDSLTRYIKSHKFSVDGGLKLLSDCNLYYEFIHSLHQSSLLPYFKTLKEIAHLFIIDGKNAEEIGKLATDTSRFSSAFHTEEVYEILHSRIDWLNIKYEVDKVIHGLACCIM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
118	Phosphorylation	LQSSDKKYADSDRPK CCCCCCCCCCCCCCC	22.75	25720772
121	Phosphorylation	SDKKYADSDRPKLSS CCCCCCCCCCCCCCC	27.61	25720772
127	Phosphorylation	DSDRPKLSSSSLLSL CCCCCCCCCCHHCCC	34.01	24763107
128	Phosphorylation	SDRPKLSSSSLLSLP CCCCCCCCCHHCCCC	34.09	21712547
129	Phosphorylation	DRPKLSSSSLLSLPD CCCCCCCCHHCCCCC	22.94	21712547
130	Phosphorylation	RPKLSSSSLLSLPDQ CCCCCCCHHCCCCCC	34.97	24763107
133	Phosphorylation	LSSSSLLSLPDQKIP CCCCHHCCCCCCCCC	43.05	24763107
477	Phosphorylation	VSLFTIPSENNSASN EEEEECCCCCCCHHH	49.45	21712547
481	Phosphorylation	TIPSENNSASNLAEK ECCCCCCCHHHHHHH	44.66	25720772
483	Phosphorylation	PSENNSASNLAEKAI CCCCCCHHHHHHHHH	32.00	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of POF6_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of POF6_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of POF6_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of POF6_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.