PO3F3_HUMAN - dbPTM
PO3F3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PO3F3_HUMAN
UniProt AC P20264
Protein Name POU domain, class 3, transcription factor 3
Gene Name POU3F3
Organism Homo sapiens (Human).
Sequence Length 500
Subcellular Localization Nucleus.
Protein Description Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity)..
Protein Sequence MATAASNPYLPGNSLLAAGSIVHSDAAGAGGGGGGGGGGGGGGAGGGGGGMQPGSAAVTSGAYRGDPSSVKMVQSDFMQGAMAASNGGHMLSHAHQWVTALPHAAAAAAAAAAAAVEASSPWSGSAVGMAGSPQQPPQPPPPPPQGPDVKGGAGRDDLHAGTALHHRGPPHLGPPPPPPHQGHPGGWGAAAAAAAAAAAAAAAAHLPSMAGGQQPPPQSLLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGDTPELAEHHHHHHHHAHPHPPHPHHAQGPPHHGGGGGGAGPGLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTPPGIQQQTPDDVYSQVGTVSADTPPPHHGLQTSVQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MATAASNPYL
-----CCCCCCCCCC		22.8125332170
9PhosphorylationATAASNPYLPGNSLL
CCCCCCCCCCCCCEE		29.7625332170
14PhosphorylationNPYLPGNSLLAAGSI
CCCCCCCCEEECCCE		30.5825332170
356PhosphorylationTLYGNVFSQTTICRF
HHHCCCCCHHHHHHH		23.4922817900
358PhosphorylationYGNVFSQTTICRFEA
HCCCCCHHHHHHHHH		19.5522817900
359PhosphorylationGNVFSQTTICRFEAL
CCCCCHHHHHHHHHH		15.5022817900
369PhosphorylationRFEALQLSFKNMCKL
HHHHHHHHHHHHHHH		22.6324719451
377UbiquitinationFKNMCKLKPLLNKWL
HHHHHHHHHHHHHHH		21.0832142685
389PhosphorylationKWLEEADSSTGSPTS
HHHHHHHCCCCCCCH		36.5329978859
390PhosphorylationWLEEADSSTGSPTSI
HHHHHHCCCCCCCHH		37.0229978859
391PhosphorylationLEEADSSTGSPTSID
HHHHHCCCCCCCHHH		45.7029978859
393PhosphorylationEADSSTGSPTSIDKI
HHHCCCCCCCHHHHH		25.7029978859
395PhosphorylationDSSTGSPTSIDKIAA
HCCCCCCCHHHHHHH		39.7629978859
396PhosphorylationSSTGSPTSIDKIAAQ
CCCCCCCHHHHHHHC		31.9729978859
411PhosphorylationGRKRKKRTSIEVSVK
CCCCCCCCCEEEEHH		42.8329978859
412PhosphorylationRKRKKRTSIEVSVKG
CCCCCCCCEEEEHHH		22.3028857561
416PhosphorylationKRTSIEVSVKGALES
CCCCEEEEHHHHHHH		12.8129978859
423PhosphorylationSVKGALESHFLKCPK
EHHHHHHHHHCCCCC		22.0123898821
478PhosphorylationQQTPDDVYSQVGTVS
CCCCCCCHHHCCEEC		10.6125002506
479PhosphorylationQTPDDVYSQVGTVSA
CCCCCCHHHCCEECC		20.4525002506
483PhosphorylationDVYSQVGTVSADTPP
CCHHHCCEECCCCCC		16.6625002506
485PhosphorylationYSQVGTVSADTPPPH
HHHCCEECCCCCCCC		21.9228857561
488PhosphorylationVGTVSADTPPPHHGL
CCEECCCCCCCCCCC		37.0928857561
497PhosphorylationPPHHGLQTSVQ----
CCCCCCCCCCC----		35.5928857561
498PhosphorylationPHHGLQTSVQ-----
CCCCCCCCCC-----		12.9328857561
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PO3F3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PO3F3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PO3F3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PO3F3_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PO3F3_HUMAN

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Related Literatures of Post-Translational Modification

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