PNG1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PNG1_ARATH
• UniProt AC: Q9FGY9
• Protein Name: Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
• Gene Name: PNG1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 721
• Subcellular Localization: Cytoplasm.
• Protein Description: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity)..
• Protein Sequence: MVARKFVVRHEDSSFDVDYNTEDGLEVLRFLIFSLTLVPPEEQKIVAEDDNRLVSDESDLASLSERLRLVSVGEDSVENSDAEMLKSDEELARMLQAEEDAIMFQQFVAARDNGEFEGRIRPYVSQVLMYEDPVRQDAARKTVPKDELEEKALVSLAKEGNFEPSKEERDYAFLLQLLFWFKKSFRWVNEPPCDFCGNKTIGQGMGNPLTSELAYGANRVEIYRCTMCPTTTRFPRYNDPLKLVETKKGRCGEWANCFTLYCRTFGYDSRLIMDFTDHVWTECYSHSLKRWIHLDPCEGVYDKPMLYEKGWNKKLNYVIAISKDGVCDVTKRYTKKWHEVLSRRTLTTESSLQDGLRTLTRERRRSLMFESLSKLELRDRNEQEELERNLHSADNASVSLPGRQSGDREWRIMRSEFGSDENSSVSSSSCPVRKCVDDHVTNIYDSFLPILTQFVEDGLPVARTNEVLKMIKQVLVDLKNAPYKTRKARLTLDSDNSSSFPEQFLPALGDLLLALSLKSERDTNGKSVTISVDGKLTKTAIALPVALDALRELVADLSKYQNLNKDSLSFPLVKQNRVCSGSVLASGEELPSGIATAAFDGIQESKWEEPNGAKGCWIVYKTLYNQMHQLIAYELMSANDAPERDPKDWILEGSNDGGSTWCVLDKQTSQVFEERFQRKSYKITTPGFQANLFRFRFLSVRDVNSTSRLQLGSIDLYRSHQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	GEDSVENSDAEMLKS CCCCCCCCCHHHHHC	25.37	23111157
366	Phosphorylation	LTRERRRSLMFESLS HCHHHHHHHHHHCHH	23.52	25561503
527	Phosphorylation	ERDTNGKSVTISVDG CCCCCCCEEEEEECC	26.37	28011693
529	Phosphorylation	DTNGKSVTISVDGKL CCCCCEEEEEECCEE	18.02	28011693
680	Phosphorylation	EERFQRKSYKITTPG HHHHHHCCCCCCCCC	33.57	25368622
681	Phosphorylation	ERFQRKSYKITTPGF HHHHHCCCCCCCCCC	14.94	25368622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PNG1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PNG1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PNG1_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of PNG1_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.