PMYT1_XENLA - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PMYT1_XENLA
• UniProt AC: Q91618
• Protein Name: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
• Gene Name: pkmyt1
• Organism: Xenopus laevis (African clawed frog).
• Sequence Length: 548
• Subcellular Localization: Endoplasmic reticulum membrane ; Peripheral membrane protein . Golgi apparatus membrane ; Peripheral membrane protein .
• Protein Description: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development..
• Protein Sequence: MPVPGDDMGETPLTRTPIPMPAYFSQAEQSFSLKKRGRSLCYTLPPRPPVKSALPVSRIFPNKQRSWSQPRPQSVSFRSPQNKTPASKLYDQSKGDTFFKQCFKSICKLGRGSFGEVYKVQSLEDGCFYAVKRSVSPFRGESDRQRKLQEVRKHERVGEHPNCLRFVRAWEEKRMLYLQTELCAGSLQQHSEEFAGSLPPRRVWNITCDLLHGLKHLHDRNLLHLDIKPANVFISFSGVCKLGDFGLMVELDGTEGSGEAQEGDPRYMAPELLDGIFSKAADVFSLGMSLLEVACNMELPKGGDGWQQLRQGHLPTEFTSDLPPDFLKVLSAMLEPDYRRRATVDWLLSLPAIRNAERWRMVTLAQERTLGKIIAVYQFIVWLLSFVFQWLNRPVIGFLHYCGLRALPRSPPCSPFPNHLGESSFSSDWDDESLGDDVFEVPPSPLATHRNLTYHGQELIGRHSPDLLSRPSLGSTSTPRNLSPEFSMRKRSALPLTPNVSRISQDSTGKSRSPSTSHSSSGFVDAEVQRTLFLPRNLLGMFDDATEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
478	Phosphorylation	PSLGSTSTPRNLSPE CCCCCCCCCCCCCCC	26.76	15692562

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
66	S	Phosphorylation	Kinase	PKMYT1	-	GPS
76	S	Phosphorylation	Kinase	PKMYT1	-	GPS
410	S	Phosphorylation	Kinase	CDK1	-	GPS
410	S	Phosphorylation	Kinase	CDK2	-	GPS
414	S	Phosphorylation	Kinase	CDK1	-	GPS
414	S	Phosphorylation	Kinase	CDK2	-	GPS
424	S	Phosphorylation	Kinase	PLK1	-	GPS
444	S	Phosphorylation	Kinase	CDK1	-	GPS
444	S	Phosphorylation	Kinase	CDK2	-	GPS
478	T	Phosphorylation	Kinase	CDK2	-	GPS
478	T	Phosphorylation	Kinase	CDK1	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PMYT1_XENLA !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PMYT1_XENLA !!

Protein-Protein Interaction

Oops, there are no PPI records of PMYT1_XENLA !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The Polo-like kinase Plx1 interacts with and inhibits Myt1 afterfertilization of Xenopus eggs.";
Inoue D., Sagata N.;
EMBO J. 24:1057-1067(2005).
Cited for: PHOSPHORYLATION AT THR-478 BY CDK1, AND PHOSPHORYLATION BY PLK1.
PubMed: 15692562