PME18_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PME18_ARATH
• UniProt AC: Q1JPL7
• Protein Name: Pectinesterase/pectinesterase inhibitor 18
• Gene Name: PME18
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 557
• Subcellular Localization: Secreted, cell wall.
• Protein Description: Acts in the modification of cell walls via demethylesterification of cell wall pectin. Inhibits the elongation phase of protein synthesis..
• Protein Sequence: MSNSNQPLLSKPKSLKHKNLCLVLSFVAILGSVAFFTAQLISVNTNNNDDSLLTTSQICHGAHDQDSCQALLSEFTTLSLSKLNRLDLLHVFLKNSVWRLESTMTMVSEARIRSNGVRDKAGFADCEEMMDVSKDRMMSSMEELRGGNYNLESYSNVHTWLSSVLTNYMTCLESISDVSVNSKQIVKPQLEDLVSRARVALAIFVSVLPARDDLKMIISNRFPSWLTALDRKLLESSPKTLKVTANVVVAKDGTGKFKTVNEAVAAAPENSNTRYVIYVKKGVYKETIDIGKKKKNLMLVGDGKDATIITGSLNVIDGSTTFRSATVAANGDGFMAQDIWFQNTAGPAKHQAVALRVSADQTVINRCRIDAYQDTLYTHTLRQFYRDSYITGTVDFIFGNSAVVFQNCDIVARNPGAGQKNMLTAQGREDQNQNTAISIQKCKITASSDLAPVKGSVKTFLGRPWKLYSRTVIMQSFIDNHIDPAGWFPWDGEFALSTLYYGEYANTGPGADTSKRVNWKGFKVIKDSKEAEQFTVAKLIQGGLWLKPTGVTFQEWL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
298	Sulfoxidation	GKKKKNLMLVGDGKD CCCCCCEEEEECCCC	3.89	23289948
307	Phosphorylation	VGDGKDATIITGSLN EECCCCCEEEEECEE	24.05	25368622
310	Phosphorylation	GKDATIITGSLNVID CCCCEEEEECEEEEC	19.50	25368622
312	Phosphorylation	DATIITGSLNVIDGS CCEEEEECEEEECCC	14.23	25368622
319	Phosphorylation	SLNVIDGSTTFRSAT CEEEECCCCEEEEEE	22.11	25368622
320	Phosphorylation	LNVIDGSTTFRSATV EEEECCCCEEEEEEE	35.17	25368622
321	Phosphorylation	NVIDGSTTFRSATVA EEECCCCEEEEEEEE	20.81	25368622
422	Sulfoxidation	PGAGQKNMLTAQGRE CCCCHHCCEECCCCC	4.54	23289948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PME18_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PME18_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PME18_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of PME18_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.