PMA4_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PMA4_ARATH
• UniProt AC: Q9SU58
• Protein Name: ATPase 4, plasma membrane-type
• Gene Name: AHA4
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 960
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: The plasma membrane H(+) ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses (By similarity)..
• Protein Sequence: MTTTVEDNREVLEAVLKEAVDLENVPIEEVFENLRCSKEGLTTQAADERLALFGHNKLEEKKESKFLKFLGFMWNPLSWVMEAAAIMAIALANGGGKPPDWQDFVGIITLLVINSTISFIEENNAGNAAAALMARLAPKAKVLRDGRWGEQDAAILVPGDIISIKLGDIVPADARLLEGDPLKIDQSALTGESLPVTKSSGDGVYSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDTTNQIGHFQQVLTAIGNFCICSIAVGMLIEIVVMYPIQHRAYRPGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHRLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLTVDKNLIEVFMKGVDADTVVLMAARASRLENQDAIDAAIVGMLADPKDARAGIQEVHFLPFNPTDKRTALTYIDNEGNTHRVSKGAPEQILNLAHNKSEIERRVHAVIDKFAERGLRSLAVAYQDVPEGRKDSAGGPWQFVGLMPLFDPPRHDSAETIRRALNLGVSVKMITGDQLAIGKETGRRLGMGTNMYPSSALLGQNKDESIVALPVDELIEKADGFAGVFPEHKYEIVKRLQARKHICGMTGDGVNDAPALKKADIGIAVADATDAARSASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVLGFMLLALIWQFDFPPFMVLIIAILNDGTIMTISKDRVKPSPLPDSWKLSEIFATGVVFGSYMAMMTVIFFWVSYKTDFFPRTFGVATLEKTAHDDFRKLASAIYLQVSIISQALIFVTRSRSWSFVERPGIFLMIAFILAQLVATLIAVYANWSFAAIEGIGWGWAGVIWLYNIIFYIPLDFIKFFIRYALSGRAWDLVIEQRVAFTRQKDFGKEQRELQWAHAQRTLHGLQAPDTKMFTDRTHVSELNQMAEEAKRRAEIARLRELHTLKGHVESVVRLKGLDIETIQQAYTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
299	Phosphorylation	GIPIAMPTVLSVTMA CCCCCCHHHHHHHHH	22.46	15308754
309	Phosphorylation	SVTMAIGSHRLSQQG HHHHHHCCHHHHHCC	10.18	29797451
323	Phosphorylation	GAITKRMTAIEEMAG CCHHHHHHHHHHHHC	28.63	19880383
336	Phosphorylation	AGMDVLCSDKTGTLT HCCCEEECCCCCEEE	37.67	19880383
519	Phosphorylation	GVSVKMITGDQLAIG CCEEEEECCCCEEEC	31.07	17317660
893	Phosphorylation	QWAHAQRTLHGLQAP HHHHHHHHHCCCCCC	15.83	17317660
942	Phosphorylation	TLKGHVESVVRLKGL HHHCHHHEEEEECCC	25.48	25561503
953	Phosphorylation	LKGLDIETIQQAYTV ECCCCHHHHHHHHCC	25.15	23776212
958	Phosphorylation	IETIQQAYTV----- HHHHHHHHCC-----	12.05	23776212
959	Phosphorylation	ETIQQAYTV------ HHHHHHHCC------	23.82	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PMA4_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PMA4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PMA4_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of PMA4_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteomics of the Arabidopsis plasma membrane and a newphosphorylation site database.";
Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
Plant Cell 16:2394-2405(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-959, SUBCELLULARLOCATION, AND MASS SPECTROMETRY.
PubMed: 15308754

"Large-scale analysis of in vivo phosphorylated membrane proteins byimmobilized metal ion affinity chromatography and mass spectrometry.";
Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
Mol. Cell. Proteomics 2:1234-1243(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-959, AND MASSSPECTROMETRY.
PubMed: 14506206