PLPR4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLPR4_HUMAN
• UniProt AC: Q7Z2D5
• Protein Name: Phospholipid phosphatase-related protein type 4 {ECO:0000305}
• Gene Name: PLPPR4 {ECO:0000312|HGNC:HGNC:23496}
• Organism: Homo sapiens (Human).
• Sequence Length: 763
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus..
• Protein Sequence: MQRAGSSGGRGECDISGAGRLGLEEAARLSCAVHTSPGGGRRPGQAAGMSAKERPKGKVIKDSVTLLPCFYFVELPILASSVVSLYFLELTDVFKPVHSGFSCYDRSLSMPYIEPTQEAIPFLMLLSLAFAGPAITIMVGEGILYCCLSKRRNGVGLEPNINAGGCNFNSFLRRAVRFVGVHVFGLCSTALITDIIQLSTGYQAPYFLTVCKPNYTSLNVSCKENSYIVEDICSGSDLTVINSGRKSFPSQHATLAAFAAVYVSMYFNSTLTDSSKLLKPLLVFTFIICGIICGLTRITQYKNHPVDVYCGFLIGGGIALYLGLYAVGNFLPSDESMFQHRDALRSLTDLNQDPNRLLSAKNGSSSDGIAHTEGILNRNHRDASSLTNLKRANADVEIITPRSPMGKENMVTFSNTLPRANTPSVEDPVRRNASIHASMDSARSKQLLTQWKNKNESRKLSLQVIEPEPGQSPPRSIEMRSSSEPSRVGVNGDHHGPGNQYLKIQPGAVPGCNNSMPGGPRVSIQSRPGSSQLVHIPEETQENISTSPKSSSARAKWLKAAEKTVACNRSNSQPRIMQVIAMSKQQGVLQSSPKNTEGSTVSCTGSIRYKTLTDHEPSGIVRVEAHPENNRPIIQIPSTEGEGSGSWKWKAPEKGSLRQTYELNDLNRDSESCESLKDSFGSGDRKRSNIDSNEHHHHGITTIRVTPVEGSEIGSETLSISSSRDSTLRRKGNIILIPERSNSPENTRNIFYKGTSPTRAYKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	LSCAVHTSPGGGRRP HHEEEECCCCCCCCC		-
50	Phosphorylation	PGQAAGMSAKERPKG CCCCCCCCCCCCCCC		29759185
209	Phosphorylation	YQAPYFLTVCKPNYT CCCCEEEEEECCCCE		-
214	N-linked_Glycosylation	FLTVCKPNYTSLNVS EEEEECCCCEEEEEE		UniProtKB CARBOHYD
219	N-linked_Glycosylation	KPNYTSLNVSCKENS CCCCEEEEEEECCCE		UniProtKB CARBOHYD
226	Phosphorylation	NVSCKENSYIVEDIC EEEECCCEEEEEEEC		-
247	Phosphorylation	VINSGRKSFPSQHAT EEECCCCCCCCHHHH		-
254	Phosphorylation	SFPSQHATLAAFAAV CCCCHHHHHHHHHHH		22210691
264	Phosphorylation	AFAAVYVSMYFNSTL HHHHHHHHHHHCCCC		22210691
266	Phosphorylation	AAVYVSMYFNSTLTD HHHHHHHHHCCCCCC		22210691
268	N-linked_Glycosylation	VYVSMYFNSTLTDSS HHHHHHHCCCCCCHH		UniProtKB CARBOHYD
346	Phosphorylation	QHRDALRSLTDLNQD HCHHHHHHHHHCCCC		27732954
348	Phosphorylation	RDALRSLTDLNQDPN HHHHHHHHHCCCCHH		27732954
362	N-linked_Glycosylation	NRLLSAKNGSSSDGI HHHHHCCCCCCCCCC		UniProtKB CARBOHYD
364	Phosphorylation	LLSAKNGSSSDGIAH HHHCCCCCCCCCCCH		27732954
365	Phosphorylation	LSAKNGSSSDGIAHT HHCCCCCCCCCCCHH		27732954
366	Phosphorylation	SAKNGSSSDGIAHTE HCCCCCCCCCCCHHH		27732954
384	Phosphorylation	NRNHRDASSLTNLKR CCCCCCHHHHHCHHH		27732954
385	Phosphorylation	RNHRDASSLTNLKRA CCCCCHHHHHCHHHH		22617229
387	Phosphorylation	HRDASSLTNLKRANA CCCHHHHHCHHHHCC		27732954
400	Phosphorylation	NADVEIITPRSPMGK CCCEEEECCCCCCCC		24719451
403	Phosphorylation	VEIITPRSPMGKENM EEEECCCCCCCCCCE		24117733
412	Phosphorylation	MGKENMVTFSNTLPR CCCCCEEEECCCCCC		27732954
414	Phosphorylation	KENMVTFSNTLPRAN CCCEEEECCCCCCCC		27732954
416	Phosphorylation	NMVTFSNTLPRANTP CEEEECCCCCCCCCC		27732954
432	N-linked_Glycosylation	VEDPVRRNASIHASM CCCCHHHCCCCCCCC		UniProtKB CARBOHYD
434	Phosphorylation	DPVRRNASIHASMDS CCHHHCCCCCCCCCC		24719451
438	Phosphorylation	RNASIHASMDSARSK HCCCCCCCCCCHHHH		30387612
449	Phosphorylation	ARSKQLLTQWKNKNE HHHHHHHHHHHCCCH		24719451
455	N-linked_Glycosylation	LTQWKNKNESRKLSL HHHHHCCCHHCCEEE		UniProtKB CARBOHYD
461	Phosphorylation	KNESRKLSLQVIEPE CCHHCCEEEEEECCC		27732954
472	Phosphorylation	IEPEPGQSPPRSIEM ECCCCCCCCCCCEEE		27732954
501	Phosphorylation	HHGPGNQYLKIQPGA CCCCCCCCEEECCCC		25884760
513	N-linked_Glycosylation	PGAVPGCNNSMPGGP CCCCCCCCCCCCCCC		UniProtKB CARBOHYD
540	Phosphorylation	LVHIPEETQENISTS EEECCHHHHHCCCCC		27732954
543	N-linked_Glycosylation	IPEETQENISTSPKS CCHHHHHCCCCCCCC		UniProtKB CARBOHYD
545	Phosphorylation	EETQENISTSPKSSS HHHHHCCCCCCCCHH		26699800
546	Phosphorylation	ETQENISTSPKSSSA HHHHCCCCCCCCHHH		26699800
547	Phosphorylation	TQENISTSPKSSSAR HHHCCCCCCCCHHHH		26699800
568	N-linked_Glycosylation	AEKTVACNRSNSQPR HHHHHHCCCCCCCCC		UniProtKB CARBOHYD
583	Phosphorylation	IMQVIAMSKQQGVLQ HHHHHHHHHHCCCCC		29978859
591	Phosphorylation	KQQGVLQSSPKNTEG HHCCCCCCCCCCCCC		27732954
592	Phosphorylation	QQGVLQSSPKNTEGS HCCCCCCCCCCCCCC		27732954
606	Phosphorylation	STVSCTGSIRYKTLT CEEECCEEEEEEECC		-
638	Phosphorylation	RPIIQIPSTEGEGSG CCCEECCCCCCCCCC		24425749
646	Phosphorylation	TEGEGSGSWKWKAPE CCCCCCCCCEECCCC		24425749
661	Phosphorylation	KGSLRQTYELNDLNR CCCCCEEEECCCCCC		25884760
670	Phosphorylation	LNDLNRDSESCESLK CCCCCCCCHHHHHHH		27732954
672	Phosphorylation	DLNRDSESCESLKDS CCCCCCHHHHHHHHH		27732954
675	Phosphorylation	RDSESCESLKDSFGS CCCHHHHHHHHHCCC		27732954
679	Phosphorylation	SCESLKDSFGSGDRK HHHHHHHHCCCCCCC		27732954
721	Phosphorylation	GSETLSISSSRDSTL CCEEEEEECCCCCCC		24905233
722	Phosphorylation	SETLSISSSRDSTLR CEEEEEECCCCCCCC		24905233
723	Phosphorylation	ETLSISSSRDSTLRR EEEEEECCCCCCCCC		24905233
726	Phosphorylation	SISSSRDSTLRRKGN EEECCCCCCCCCCCE		21406692
727	Phosphorylation	ISSSRDSTLRRKGNI EECCCCCCCCCCCEE		21406692
741	Phosphorylation	IILIPERSNSPENTR EEEECCCCCCCCCCC		22617229

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLPR4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLPR4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLPR4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PLPR4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.