PLPL7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLPL7_HUMAN
• UniProt AC: Q6ZV29
• Protein Name: Patatin-like phospholipase domain-containing protein 7
• Gene Name: PNPLA7
• Organism: Homo sapiens (Human).
• Sequence Length: 1317
• Subcellular Localization: Membrane ; Single-pass membrane protein . Nucleus membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. Found i
• Protein Description: Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy..
• Protein Sequence: MEEEKDDSPQLTGIAVGALLALALVGVLILFMFRRLRQFRQAQPTPQYRFRKRDKVMFYGRKIMRKVTTLPNTLVENTALPRQRARKRTKVLSLAKRILRFKKEYPALQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHIVFVQLQEGEHVFQPREPDPSICVVQDGRLEVCIQDTDGTEVVVKEVLAGDSVHSLLSILDIITGHAAPYKTVSVRAAIPSTILRLPAAAFHGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNAESQAIPLVSVASVAAGKAKKQVFYGEEERLKKPPRLQESCDSDHGGGRPAAAGPLLKRSHSVPAPSIRKQILEELEKPGAGDPDPSAPQGGPGSATSDLGMACDRARVFLHSDEHPGSSVASKSRKSVMVAEIPSTVSQHSESHTDETLASRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLHVPAGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIMRKQPTVVLGVAHTVVKRMSSFVRQIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGPVTGHQLGLPTEGSKWDLGNPAVNLSTVAVMPVSEEVPLTAFALELEHALSAIGPTLLLTSDNIKRRLGSAALDSVHEYRLSSWLGQQEDTHRIVLYQADGTLTPWTQRCVRQADCILIVGLGDQEPTVGELERMLESTAVRAQKQLILLHREEGPAPARTVEWLNMRSWCSGHLHLCCPRRVFSRRSLPKLVEMYKHVFQRPPDRHSDFSRLARVLTGNAIALVLGGGGARGCAQVGVLKALAECGIPVDMVGGTSIGAFVGALYSEERNYSQMRIRAKQWAEGMTSLMKAALDLTYPITSMFSGAGFNSSIFSVFKDQQIEDLWIPYFAITTDITASAMRVHTDGSLWWYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEVVKSSDYCEYLRPPIDSYSTLDFGKFNEICEVGYQHGRTVFDIWGRSGVLEKMLRDQQGPSKKPASAVLTCPNASFTDLAEIVSRIEPAKPAMVDDESDYQTEYEEELLDVPRDAYADFQSTSAQQGSDLEDESSLRHRHPSLAFPKLSEGSSDQDG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37 (in isoform 5)	Phosphorylation	-	31.60	26552605
37 (in isoform 2)	Phosphorylation	-	31.60	26552605
55	Acetylation	YRFRKRDKVMFYGRK CCCCCCCCEEECCHH	39.36	19413330
59	Phosphorylation	KRDKVMFYGRKIMRK CCCCEEECCHHHHHH	9.64	19413330
80	Acetylation	TLVENTALPRQRARK CHHHCCCCCHHHHHH	3.19	19413330
89	Phosphorylation	RQRARKRTKVLSLAK HHHHHHHHHHHHHHH	28.65	-
119	Ubiquitination	EPPPSLLEADLTEFD CCCCCHHCCCCCCCC	45.49	25015289
128	Ubiquitination	DLTEFDVKNSHLPSE CCCCCCCCCCCCCHH	55.36	25015289
130	Phosphorylation	TEFDVKNSHLPSEVL CCCCCCCCCCCHHHH	22.23	23663014
134	Phosphorylation	VKNSHLPSEVLYMLK CCCCCCCHHHHHHHH	46.85	23663014
138	Phosphorylation	HLPSEVLYMLKNVRV CCCHHHHHHHHCCEE	12.94	23663014
153	Ubiquitination	LGHFEKPLFLELCKH CCCCCCHHHHHHHCC	13.01	25015289
215	Phosphorylation	LAGDSVHSLLSILDI HHCCCHHHHHHHHHH	28.93	-
230	Phosphorylation	ITGHAAPYKTVSVRA HHCCCCCCCEEEHHH	17.98	-
333	Phosphorylation	KPPRLQESCDSDHGG CCCCHHHHCCCCCCC	15.40	20873877
336	Phosphorylation	RLQESCDSDHGGGRP CHHHHCCCCCCCCCC	35.52	20873877
353	Phosphorylation	AGPLLKRSHSVPAPS HHHHHHCCCCCCCHH	20.66	26437602
355	Phosphorylation	PLLKRSHSVPAPSIR HHHHCCCCCCCHHHH	30.92	25849741
360	Phosphorylation	SHSVPAPSIRKQILE CCCCCCHHHHHHHHH	36.81	23312004
380	Phosphorylation	GAGDPDPSAPQGGPG CCCCCCCCCCCCCCC	61.02	24719451
461	Phosphorylation	AAKKDLLTLMKLEDS HHHHHHHHHHCCCCC	31.91	-
469	Phosphorylation	LMKLEDSSLLDGRVA HHCCCCCCCCCCCEE	45.32	25921289
553	Phosphorylation	NRDCSFLSISKAHFY CCCCCEEEECHHHHH	23.86	24719451
613	Phosphorylation	QGDKSDCTYIMLSGR CCCCCCCEEEEECCC	22.52	24719451
614	Phosphorylation	GDKSDCTYIMLSGRL CCCCCCEEEEECCCH	7.23	-
627	Acetylation	RLRSVIRKDDGKKRL CHHHEEECCCCCEEE	49.39	30591419
632	Acetylation	IRKDDGKKRLAGEYG EECCCCCEEECCCCC	59.16	30591425
638	Phosphorylation	KKRLAGEYGRGDLVG CEEECCCCCCCCEEE	15.94	24719451
665	Phosphorylation	TVHAVRDSELAKLPA EEEECCCHHHHCCCC	24.76	26074081
676	Phosphorylation	KLPAGALTSIKRRYP CCCCCHHHHHHHHHH	28.07	26074081
677	Phosphorylation	LPAGALTSIKRRYPQ CCCCHHHHHHHHHHH	27.28	26074081
682	Phosphorylation	LTSIKRRYPQVVTRL HHHHHHHHHHHHHHH	11.31	26074081
687	Phosphorylation	RRYPQVVTRLIHLLG HHHHHHHHHHHHHHH	22.39	26074081
718	Phosphorylation	LGLPTEGSKWDLGNP CCCCCCCCCCCCCCC	25.09	-
728	N-linked_Glycosylation	DLGNPAVNLSTVAVM CCCCCCCCCCEEEEE	30.31	UniProtKB CARBOHYD
912	Phosphorylation	QRPPDRHSDFSRLAR CCCCCCCCCHHHHHH	41.04	20860994
915	Phosphorylation	PDRHSDFSRLARVLT CCCCCCHHHHHHHHH	31.23	20860994
975	N-linked_Glycosylation	ALYSEERNYSQMRIR HHHHCCCCCHHHHHH	44.05	UniProtKB CARBOHYD
991	Phosphorylation	KQWAEGMTSLMKAAL HHHHHHHHHHHHHHH	29.57	29759185
992	Phosphorylation	QWAEGMTSLMKAALD HHHHHHHHHHHHHHH	19.99	28165663
1001	Phosphorylation	MKAALDLTYPITSMF HHHHHHCCCCHHHHC	27.24	28165663
1002	Phosphorylation	KAALDLTYPITSMFS HHHHHCCCCHHHHCC	10.43	28165663
1005	Phosphorylation	LDLTYPITSMFSGAG HHCCCCHHHHCCCCC	15.05	23879269
1014	N-linked_Glycosylation	MFSGAGFNSSIFSVF HCCCCCCCCHHHHHH	33.65	UniProtKB CARBOHYD
1015	Phosphorylation	FSGAGFNSSIFSVFK CCCCCCCCHHHHHHC	23.66	28165663
1016	Phosphorylation	SGAGFNSSIFSVFKD CCCCCCCHHHHHHCC	28.85	28165663
1019	Phosphorylation	GFNSSIFSVFKDQQI CCCCHHHHHHCCCCH	25.60	28165663
1084	Phosphorylation	HLLMDGGYINNLPAD CEEECCCCCCCCCHH	13.15	-
1233	N-linked_Glycosylation	SAVLTCPNASFTDLA CEEEECCCCCHHHHH	50.81	UniProtKB CARBOHYD
1235	Phosphorylation	VLTCPNASFTDLAEI EEECCCCCHHHHHHH	35.01	26657352
1258	Phosphorylation	PAMVDDESDYQTEYE CCCCCCCCHHCCHHH	48.92	26657352
1260	Phosphorylation	MVDDESDYQTEYEEE CCCCCCHHCCHHHHH	26.98	22798277
1262	Phosphorylation	DDESDYQTEYEEELL CCCCHHCCHHHHHHH	34.01	22798277
1282	Phosphorylation	AYADFQSTSAQQGSD HHHCHHCCCCCCCCC	19.80	28348404
1283	Phosphorylation	YADFQSTSAQQGSDL HHCHHCCCCCCCCCC	29.36	26657352
1288	Phosphorylation	STSAQQGSDLEDESS CCCCCCCCCCCCHHH	34.38	28258704
1294	Phosphorylation	GSDLEDESSLRHRHP CCCCCCHHHHCCCCH	47.17	25072903
1295	Phosphorylation	SDLEDESSLRHRHPS CCCCCHHHHCCCCHH	27.63	25072903
1302	Phosphorylation	SLRHRHPSLAFPKLS HHCCCCHHHCCCCCC	26.63	22985185
1307	Phosphorylation	HPSLAFPKLSEGSSD CHHHCCCCCCCCCCC	59.18	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLPL7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLPL7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLPL7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RNF14_HUMAN	RNF14	physical	26606397

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.