PLPL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLPL3_HUMAN
• UniProt AC: Q9NST1
• Protein Name: Patatin-like phospholipase domain-containing protein 3
• Gene Name: PNPLA3
• Organism: Homo sapiens (Human).
• Sequence Length: 481
• Subcellular Localization: Membrane ; Single-pass type II membrane protein .
• Protein Description: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities..
• Protein Sequence: MYDAERGWSLSFAGCGFLGFYHVGATRCLSEHAPHLLRDARMLFGASAGALHCVGVLSGIPLEQTLQVLSDLVRKARSRNIGIFHPSFNLSKFLRQGLCKCLPANVHQLISGKIGISLTRVSDGENVLVSDFRSKDEVVDALVCSCFIPFYSGLIPPSFRGVRYVDGGVSDNVPFIDAKTTITVSPFYGEYDICPKVKSTNFLHVDITKLSLRLCTGNLYLLSRAFVPPDLKVLGEICLRGYLDAFRFLEEKGICNRPQPGLKSSSEGMDPEVAMPSWANMSLDSSPESAALAVRLEGDELLDHLRLSILPWDESILDTLSPRLATALSEEMKDKGGYMSKICNLLPIRIMSYVMLPCTLPVESAIAIVQRLVTWLPDMPDDVLWLQWVTSQVFTRVLMCLLPASRSQMPVSSQQASPCTPEQDWPCWTPCSPKGCPAETKAEATPRSILRSSLNFFLGNKVPAGAEGLSTFPSFSLEKSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	GCGFLGFYHVGATRC CCCCEEEEECCCHHH	8.19	-
87	Phosphorylation	NIGIFHPSFNLSKFL CCCEECCCCCHHHHH	20.42	22210691
89	N-linked_Glycosylation	GIFHPSFNLSKFLRQ CEECCCCCHHHHHHH	47.98	UniProtKB CARBOHYD
91	Phosphorylation	FHPSFNLSKFLRQGL ECCCCCHHHHHHHCH	23.59	22210691
92	Acetylation	HPSFNLSKFLRQGLC CCCCCHHHHHHHCHH	52.13	7678689
117	Phosphorylation	ISGKIGISLTRVSDG HCCCCCEEEEEECCC	20.62	24719451
122	Phosphorylation	GISLTRVSDGENVLV CEEEEEECCCCCEEE	36.29	-
191	Phosphorylation	VSPFYGEYDICPKVK ECCCCCCCCCCCCCC	13.27	-
211	Phosphorylation	HVDITKLSLRLCTGN EEECCHHHHHHHCCC	17.01	20058876
264	Phosphorylation	RPQPGLKSSSEGMDP CCCCCCCCCCCCCCH	44.11	-
280	N-linked_Glycosylation	VAMPSWANMSLDSSP HHCCHHCCCCCCCCH	17.83	UniProtKB CARBOHYD
286	Phosphorylation	ANMSLDSSPESAALA CCCCCCCCHHHHHHH	32.14	-
329	Phosphorylation	PRLATALSEEMKDKG HHHHHHHCHHHHHCC	29.10	27732954
338	Phosphorylation	EMKDKGGYMSKICNL HHHHCCCHHHHHHHH	13.59	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLPL3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLPL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLPL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SNX27_HUMAN	SNX27	physical	21988832
PEX14_HUMAN	PEX14	physical	26186194
S27A2_HUMAN	SLC27A2	physical	26186194
S27A2_HUMAN	SLC27A2	physical	28514442
PEX14_HUMAN	PEX14	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613282: Non-alcoholic fatty liver disease 1 (NAFLD1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.