PLIN4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLIN4_MOUSE
• UniProt AC: O88492
• Protein Name: Perilipin-4
• Gene Name: Plin4
• Organism: Mus musculus (Mouse).
• Sequence Length: 1403
• Subcellular Localization: Cell membrane . Cytoplasm . Lipid droplet . Nascent lipid droplet surface-associated; association with lipid droplets is triacylglycerol synthesis-dependent.
• Protein Description: May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets..
• Protein Sequence: MSASGDGTRVPPKSKGKTLSSFFGSLPGFSSARNLVSHTHSSTSTKDLQTATDPSGTPAPSSKVSTNSQMAGDAAGLLQPSEQTAGDKDMGSFSVTSSEDAFSGVFGIMDAAKGMVQGGLGATQSALVGTKEAVSGGVMGAVGVAKGLVKGGLDTSKNVLTNTKDTVTTGVMGAANMAKGTVQTGLDTTKSVVMGTKDTVATGLAGAVNVAKGTIQGGLDTTKSVVMGTKDTVTTGLTGAVNVAKGVVQGGLDTTKSVVMGTKDTVTTGLTGAMNVAKGTAQMGIDTSKTVLTGTKDTVCAGATGAINVAKGAAQGGLDTTKSVLIGTKDTVTTGLTGAVNVAKGAVQGGLDTTKSVVMGTKDTVTTGLTGAMNVAKGTAQMGLGTSKTVLTGTKDTVCAGLTGAINVAKGAAQGGLDTTKSVLMGTKDTVTTGLTGAVNVAKGTIQGGLDTTKSVVMGTKDTVTTGLTGAVNVAKGTIQGGLDTTKSVVMGTKDTVTTGLTGAVNVAKGAAQGGLDTTKSVVMGTKDTVTTGLTGAMNVAKGTAQMGLGTSKTVLTGTKDTVCAGLTGAINVAKGAAQGGLDTTKSVLMGTKDTVTTGLTGAVNVAKGTIQGGLDTTKSVVMGTKDTVTTGLTGAVNVAKGAVQGGLDTTKSVVMGTKDTVTTGLTGALNVAKGTAQMGIDTSKTVLIGTKDTVCAGATGAINMAKGAAQGGLDTTKSVLMGTKDTVTTGLTGAINVAKGSAQGGLDTTKSVLIGTKDTVTTGLTGALNVAKGTVQTGLDTSQRVLTGTKDNVYAGVTGAVNVAKGTIQGGLDTTKSVVMGTKDTVTTGLTGAVNVAKGAVQGGLDTTKSVVMGTKDTVTTGLTGAMNVAKGTAQMGIDTSKTVLTGTKDTVCAGLTGAINVAKGATQGGLDTTKSVLMGTKDTVTTGLTGAINVAKGAAQGGLDTTKSVLLGTKDTVTTGLTGAANVAKETVQMGLDTSKNILMDTKDSICAGATGAITVVKGAAQGGLDTSNAALTGTMDTAKGTVQTSLDTSKHMLIGMKDTVCAGVTSAMNMAKGIHKNTDTTRDTQSSVLAHSGNVATNAIHTGVHTVPSSLSGSHSIICHEPSIYRATNHGVGQAILTSTESLCCETSSFSDKYGLGHVTEPRADTKTLVSGMASSACAATRSVEECGQLAATGFAALPDELKGLGDIFQPMTTEEQAQLAVSESGPRVLSADRGSYYIRLGDLAPSFRQRAFEHALSHIQHNQFQARAALAQLQEAFQMTDMTMEAACGKLCSDQSLNTMVEAVGSHEMRASVAQDRLCTLAHQLHAAYSSLVTSLQGLPEVQQQAGQARHSLCKLYGLVSSEAGSELQTEQLAQSSAGVVEAWQGLEVLLEKLQQNPPLSWLVGPFTSMPCGQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MSASGDGTRVPPKSK CCCCCCCCCCCCCCC	32.98	28576409
20	Phosphorylation	KSKGKTLSSFFGSLP CCCCCCHHHHHCCCC	30.26	-
25	Phosphorylation	TLSSFFGSLPGFSSA CHHHHHCCCCCCHHH	26.66	23737553
30	Phosphorylation	FGSLPGFSSARNLVS HCCCCCCHHHHHHHH	29.07	22817900
31	Phosphorylation	GSLPGFSSARNLVSH CCCCCCHHHHHHHHC	29.05	22817900
37	Phosphorylation	SSARNLVSHTHSSTS HHHHHHHHCCCCCCC	26.32	27742792
39	Phosphorylation	ARNLVSHTHSSTSTK HHHHHHCCCCCCCCC	18.88	27742792
41	Phosphorylation	NLVSHTHSSTSTKDL HHHHCCCCCCCCCCC	36.14	23737553
42	Phosphorylation	LVSHTHSSTSTKDLQ HHHCCCCCCCCCCCC	20.83	23737553
43	Phosphorylation	VSHTHSSTSTKDLQT HHCCCCCCCCCCCCC	43.35	23737553
44	Phosphorylation	SHTHSSTSTKDLQTA HCCCCCCCCCCCCCC	35.09	27742792
45	Phosphorylation	HTHSSTSTKDLQTAT CCCCCCCCCCCCCCC	28.77	23737553
50	Phosphorylation	TSTKDLQTATDPSGT CCCCCCCCCCCCCCC	38.53	27742792
52	Phosphorylation	TKDLQTATDPSGTPA CCCCCCCCCCCCCCC	52.40	27742792
55	Phosphorylation	LQTATDPSGTPAPSS CCCCCCCCCCCCCCC	59.10	23737553
57	Phosphorylation	TATDPSGTPAPSSKV CCCCCCCCCCCCCCC	22.18	23737553
155	Phosphorylation	LVKGGLDTSKNVLTN HHHCCCCCCCCCCCC	46.79	21183079
156	Phosphorylation	VKGGLDTSKNVLTNT HHCCCCCCCCCCCCC	23.15	21082442
191	Phosphorylation	TGLDTTKSVVMGTKD CCCCCCCEEEECCCH	20.18	23737553
221	Phosphorylation	TIQGGLDTTKSVVMG EEECCCCCCCEEEEC	40.96	28464351
224	Phosphorylation	GGLDTTKSVVMGTKD CCCCCCCEEEECCCC	20.18	23737553
229	Phosphorylation	TKSVVMGTKDTVTTG CCEEEECCCCCCCCC	13.98	25777480
234	Phosphorylation	MGTKDTVTTGLTGAV ECCCCCCCCCCCCHH	19.76	21183079
235	Phosphorylation	GTKDTVTTGLTGAVN CCCCCCCCCCCCHHH	26.34	22817900
257	Phosphorylation	GGLDTTKSVVMGTKD CCCCCCCEEEECCCC	20.18	23737553
289	Ubiquitination	QMGIDTSKTVLTGTK ECCCCCCCEEEECCC	44.75	22790023
323	Phosphorylation	GGLDTTKSVLIGTKD CCCCCCCEEEEECCC	21.77	28542873
356	Phosphorylation	GGLDTTKSVVMGTKD CCCCCCCEEEECCCC	20.18	23737553
386	Phosphorylation	TAQMGLGTSKTVLTG EEECCCCCCCEEEEC	31.90	26060331
387	Phosphorylation	AQMGLGTSKTVLTGT EECCCCCCCEEEECC	25.24	22817900
421	Ubiquitination	QGGLDTTKSVLMGTK HCCCCCCCHHHHCCC	40.43	22790023
422	Phosphorylation	GGLDTTKSVLMGTKD CCCCCCCHHHHCCCC	20.56	-
452	Phosphorylation	TIQGGLDTTKSVVMG EEECCCCCCCEEEEC	40.96	28464351
455	Phosphorylation	GGLDTTKSVVMGTKD CCCCCCCEEEECCCC	20.18	23737553
460	Phosphorylation	TKSVVMGTKDTVTTG CCEEEECCCCEECCC	13.98	25777480
465	Phosphorylation	MGTKDTVTTGLTGAV ECCCCEECCCCCCCE	19.76	21183079
466	Phosphorylation	GTKDTVTTGLTGAVN CCCCEECCCCCCCEE	26.34	22817900
485	Phosphorylation	TIQGGLDTTKSVVMG EEECCCCCCCEEEEC	40.96	28464351
488	Phosphorylation	GGLDTTKSVVMGTKD CCCCCCCEEEECCCC	20.18	23737553
493	Phosphorylation	TKSVVMGTKDTVTTG CCEEEECCCCEECCC	13.98	25777480
498	Phosphorylation	MGTKDTVTTGLTGAV ECCCCEECCCCCCHH	19.76	21183079
499	Phosphorylation	GTKDTVTTGLTGAVN CCCCEECCCCCCHHH	26.34	22817900
521	Phosphorylation	GGLDTTKSVVMGTKD CCCCCCCEEEECCCC	20.18	23737553
551	Phosphorylation	TAQMGLGTSKTVLTG EEECCCCCCCEEEEC	31.90	26060331
552	Phosphorylation	AQMGLGTSKTVLTGT EECCCCCCCEEEECC	25.24	22817900
586	Ubiquitination	QGGLDTTKSVLMGTK HCCCCCCCHHHHCCC	40.43	-
587	Phosphorylation	GGLDTTKSVLMGTKD CCCCCCCHHHHCCCC	20.56	-
617	Phosphorylation	TIQGGLDTTKSVVMG EEECCCCCCCEEEEC	40.96	28464351
620	Phosphorylation	GGLDTTKSVVMGTKD CCCCCCCEEEECCCC	20.18	23737553
625	Phosphorylation	TKSVVMGTKDTVTTG CCEEEECCCCCCCCC	13.98	25777480
630	Phosphorylation	MGTKDTVTTGLTGAV ECCCCCCCCCCCCHH	19.76	21183079
631	Phosphorylation	GTKDTVTTGLTGAVN CCCCCCCCCCCCHHH	26.34	22817900
653	Phosphorylation	GGLDTTKSVVMGTKD CCCCCCCEEEECCCC	20.18	23737553
718	Ubiquitination	QGGLDTTKSVLMGTK HCCCCCCCHHHHCCC	40.43	-
719	Phosphorylation	GGLDTTKSVLMGTKD CCCCCCCHHHHCCCC	20.56	-
742	Phosphorylation	AINVAKGSAQGGLDT HHHHHCCCCCCCCCC	19.40	28464351
752	Phosphorylation	GGLDTTKSVLIGTKD CCCCCCCEEEEECCC	21.77	28542873
782	Phosphorylation	TVQTGLDTSQRVLTG CCCCCCCCCCHHHHC	31.63	28464351
783	Phosphorylation	VQTGLDTSQRVLTGT CCCCCCCCCHHHHCC	18.69	22817900
795	Phosphorylation	TGTKDNVYAGVTGAV HCCCCCEEEECCCCE	12.14	28464351
815	Phosphorylation	TIQGGLDTTKSVVMG EEECCCCCCCEEEEC	40.96	28464351
818	Phosphorylation	GGLDTTKSVVMGTKD CCCCCCCEEEECCCC	20.18	23737553
823	Phosphorylation	TKSVVMGTKDTVTTG CCEEEECCCCCCCCC	13.98	25777480
828	Phosphorylation	MGTKDTVTTGLTGAV ECCCCCCCCCCCCHH	19.76	21183079
829	Phosphorylation	GTKDTVTTGLTGAVN CCCCCCCCCCCCHHH	26.34	22817900
851	Phosphorylation	GGLDTTKSVVMGTKD CCCCCCCEEEECCCC	20.18	23737553
883	Ubiquitination	QMGIDTSKTVLTGTK ECCCCCCCEEEECCC	44.75	-
917	Phosphorylation	GGLDTTKSVLMGTKD CCCCCCHHHHHCCCC	20.56	-
958	Phosphorylation	VLLGTKDTVTTGLTG EECCCCCCCCCCCHH	22.70	29109428
960	Phosphorylation	LGTKDTVTTGLTGAA CCCCCCCCCCCHHHH	19.76	29109428
961	Phosphorylation	GTKDTVTTGLTGAAN CCCCCCCCCCHHHHH	26.34	21183079
964	Phosphorylation	DTVTTGLTGAANVAK CCCCCCCHHHHHHHH	26.56	22817900
1071	Phosphorylation	NTDTTRDTQSSVLAH CCCCCHHHHHHHHHC	27.36	26060331
1096	Phosphorylation	TGVHTVPSSLSGSHS CCCCCCCCHHCCCCE	39.31	26060331
1097	Phosphorylation	GVHTVPSSLSGSHSI CCCCCCCHHCCCCEE	22.08	26060331
1099	Phosphorylation	HTVPSSLSGSHSIIC CCCCCHHCCCCEEEE	39.95	26060331
1101	Phosphorylation	VPSSLSGSHSIICHE CCCHHCCCCEEEECC	15.64	26060331
1103	Phosphorylation	SSLSGSHSIICHEPS CHHCCCCEEEECCCC	18.49	22817900
1115	Phosphorylation	EPSIYRATNHGVGQA CCCHHHHCCCCCCHH	20.81	27742792
1125	Phosphorylation	GVGQAILTSTESLCC CCCHHHHHCCCCEEC	27.73	27742792
1126	Phosphorylation	VGQAILTSTESLCCE CCHHHHHCCCCEECC	27.08	27742792
1127	Phosphorylation	GQAILTSTESLCCET CHHHHHCCCCEECCC	25.10	27742792
1129	Phosphorylation	AILTSTESLCCETSS HHHHCCCCEECCCCC	27.13	27742792
1281	Phosphorylation	AACGKLCSDQSLNTM HHHHHHCCCCHHHHH	49.47	23737553
1284	Phosphorylation	GKLCSDQSLNTMVEA HHHCCCCHHHHHHHH	28.69	23737553
1287	Phosphorylation	CSDQSLNTMVEAVGS CCCCHHHHHHHHHCC	28.08	23737553
1294	Phosphorylation	TMVEAVGSHEMRASV HHHHHHCCHHHHHHH	15.07	26060331

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLIN4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLIN4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLIN4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PLIN4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.