PLIN4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLIN4_HUMAN
• UniProt AC: Q96Q06
• Protein Name: Perilipin-4
• Gene Name: PLIN4
• Organism: Homo sapiens (Human).
• Sequence Length: 1357
• Subcellular Localization: Cell membrane . Cytoplasm . Lipid droplet . Nascent lipid droplet surface-associated; association with lipid droplets is triacylglycerol synthesis-dependent.
• Protein Description: May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity)..
• Protein Sequence: MQTLGSFFGSLPGFSSARNLVANAHSSARARPAADPTGAPAAEAAQPQAQVAAHPEQTAPWTEKELQPSEKQMVSGAKDLVCSKMSRAKDAVSSGVASVVDVAKGVVQGGLDTTRSALTGTKEVVSSGVTGAMDMAKGAVQGGLDTSKAVLTGTKDTVSTGLTGAVNVAKGTVQAGVDTTKTVLTGTKDTVTTGVMGAVNLAKGTVQTGVETSKAVLTGTKDAVSTGLTGAVNVARGSIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTTKTVLTGTKNTVCSGVTGAVNLAKEAIQGGLDTTKSMVMGTKDTMSTGLTGAANVAKGAMQTGLNTTQNIATGTKDTVCSGVTGAMNLARGTIQTGVDTTKIVLTGTKDTVCSGVTGAANVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNVAKGTVQTGVDTTKTVLTGTKDTVCSGVTSAVNVAKGAVQGGLDTTKSVVIGTKDTMSTGLTGAANVAKGAVQTGVDTAKTVLTGTKDTVTTGLVGAVNVAKGTVQTGMDTTKTVLTGTKDTIYSGVTSAVNVAKGAVQTGLKTTQNIATGTKNTFGSGVTSAVNVAKGAAQTGVDTAKTVLTGTKDTVTTGLMGAVNVAKGTVQTSVDTTKTVLTGTKDTVCSGVTGAANVAKGAIQGGLDTTKSVLTGTKDAVSTGLTGAVKLAKGTVQTGMDTTKTVLTGTKDAVCSGVTGAANVAKGAVQMGVDTAKTVLTGTKDTVCSGVTGAANVAKGAVQTGLKTTQNIATGTKNTLGSGVTGAAKVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNLAKGTVQTGVDTSKTVLTGTKDTVCSGVTGAVNVAKGTVQTGVDTAKTVLSGAKDAVTTGVTGAVNVAKGTVQTGVDASKAVLMGTKDTVFSGVTGAMSMAKGAVQGGLDTTKTVLTGTKDAVSAGLMGSGNVATGATHTGLSTFQNWLPSTPATSWGGLTSSRTTDNGGEQTALSPQEAPFSGISTPPDVLSVGPEPAWEAAATTKGLATDVATFTQGAAPGREDTGLLATTHGPEEAPRLAMLQNELEGLGDIFHPMNAEEQAQLAASQPGPKVLSAEQGSYFVRLGDLGPSFRQRAFEHAVSHLQHGQFQARDTLAQLQDCFRLIEKAQQAPEGQPRLDQGSGASAEDAAVQEERDAGVLSRVCGLLRQLHTAYSGLVSSLQGLPAELQQPVGRARHSLCELYGIVASAGSVEELPAERLVQSREGVHQAWQGLEQLLEGLQHNPPLSWLVGPFALPAGGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MQTLGSFFGS -----CCCHHHHHCC	44.97	23663014
6	Phosphorylation	--MQTLGSFFGSLPG --CCCHHHHHCCCCC	22.10	26657352
10	Phosphorylation	TLGSFFGSLPGFSSA CHHHHHCCCCCCHHH	26.66	23663014
15	Phosphorylation	FGSLPGFSSARNLVA HCCCCCCHHHHHHHH	29.07	24043423
16	Phosphorylation	GSLPGFSSARNLVAN CCCCCCHHHHHHHHH	29.05	24043423
26	Phosphorylation	NLVANAHSSARARPA HHHHHHHHHHCCCCC	24.23	24719451
27	Phosphorylation	LVANAHSSARARPAA HHHHHHHHHCCCCCC	16.35	23312004
69	Phosphorylation	TEKELQPSEKQMVSG CHHHCCCCHHHHCCC	44.45	30622161
71	Ubiquitination	KELQPSEKQMVSGAK HHCCCCHHHHCCCHH	48.29	21906983
71 (in isoform 1)	Ubiquitination	-	48.29	21906983
71 (in isoform 2)	Ubiquitination	-	48.29	21906983
75	Phosphorylation	PSEKQMVSGAKDLVC CCHHHHCCCHHHHHH	27.91	23090842
78	Ubiquitination	KQMVSGAKDLVCSKM HHHCCCHHHHHHHHH	55.94	2190698
78 (in isoform 1)	Ubiquitination	-	55.94	21906983
78 (in isoform 2)	Ubiquitination	-	55.94	21906983
83	Phosphorylation	GAKDLVCSKMSRAKD CHHHHHHHHHHHHHH	24.74	23090842
86	Phosphorylation	DLVCSKMSRAKDAVS HHHHHHHHHHHHHHH	32.59	23090842
93	Phosphorylation	SRAKDAVSSGVASVV HHHHHHHHHCCHHHH	24.09	27251275
94	Phosphorylation	RAKDAVSSGVASVVD HHHHHHHHCCHHHHH	30.59	27251275
98	Phosphorylation	AVSSGVASVVDVAKG HHHHCCHHHHHHHHH	21.92	27251275
116	Phosphorylation	GGLDTTRSALTGTKE CCHHHHHHHHHCCHH	26.07	26437602
121	Phosphorylation	TRSALTGTKEVVSSG HHHHHHCCHHHHHCC	20.85	26437602
126	Phosphorylation	TGTKEVVSSGVTGAM HCCHHHHHCCCCCCH	26.93	29083192
127	Phosphorylation	GTKEVVSSGVTGAMD CCHHHHHCCCCCCHH	26.18	29083192
130	Phosphorylation	EVVSSGVTGAMDMAK HHHHCCCCCCHHHHH	23.81	29083192
146	Phosphorylation	AVQGGLDTSKAVLTG HHCCCCCCCCEEHHC	36.85	27251275
147	Phosphorylation	VQGGLDTSKAVLTGT HCCCCCCCCEEHHCC	20.48	26437602
159	Phosphorylation	TGTKDTVSTGLTGAV HCCCCCCCCCCCCCE	20.89	27251275
160	Phosphorylation	GTKDTVSTGLTGAVN CCCCCCCCCCCCCEE	31.69	27251275
180	O-linked_Glycosylation	VQAGVDTTKTVLTGT EEECCCCCCEEEECC	21.91	30379171
182	Phosphorylation	AGVDTTKTVLTGTKD ECCCCCCEEEECCCC	20.75	26437602
190	Phosphorylation	VLTGTKDTVTTGVMG EEECCCCCCCCHHHH	22.70	-
225	Phosphorylation	TGTKDAVSTGLTGAV CCCHHHHHCCCCCHH	20.62	27251275
226	Phosphorylation	GTKDAVSTGLTGAVN CCHHHHHCCCCCHHH	29.61	27251275
238	Phosphorylation	AVNVARGSIQTGVDT HHHHHCCCCCCCCCC	13.13	26657352
248	Phosphorylation	TGVDTSKTVLTGTKD CCCCCCCEEEECCCC	22.10	26437602
262	Phosphorylation	DTVCSGVTGAMNVAK CCCCCHHHHCCHHHC	23.81	30576142
278	Phosphorylation	TIQTGVDTSKTVLTG EEECCCCCCCEEEEC	29.71	27251275
279	Phosphorylation	IQTGVDTSKTVLTGT EECCCCCCCEEEECC	23.13	27251275
281	Phosphorylation	TGVDTSKTVLTGTKD CCCCCCCEEEECCCC	22.10	26437602
295	Phosphorylation	DTVCSGVTGAMNVAK CCCCCHHHHCCHHHC	23.81	30576142
311	Phosphorylation	TIQTGVDTSKTVLTG EEECCCCCCCEEEEC	29.71	27251275
312	Phosphorylation	IQTGVDTSKTVLTGT EECCCCCCCEEEECC	23.13	27251275
314	Phosphorylation	TGVDTSKTVLTGTKD CCCCCCCEEEECCCC	22.10	26437602
328	Phosphorylation	DTVCSGVTGAMNVAK CCCCCHHHHCCHHHC	23.81	30576142
337	Phosphorylation	AMNVAKGTIQTGVDT CCHHHCCEEECCCCC	14.81	26437602
347	Phosphorylation	TGVDTTKTVLTGTKN CCCCCCCEEEECCCC	20.75	26437602
378	O-linked_Glycosylation	IQGGLDTTKSMVMGT HHCCCCCCCHHHCCC	22.31	30379171
380	Phosphorylation	GGLDTTKSMVMGTKD CCCCCCCHHHCCCCC	17.95	26437602
390	Phosphorylation	MGTKDTMSTGLTGAA CCCCCCCCCCCCHHH	22.78	27251275
391	Phosphorylation	GTKDTMSTGLTGAAN CCCCCCCCCCCHHHH	25.95	27251275
406	Phosphorylation	VAKGAMQTGLNTTQN HHHHHHHHCCCCCCC	30.47	-
418	Phosphorylation	TQNIATGTKDTVCSG CCCCCCCCCCCHHCH	22.76	-
436	Phosphorylation	AMNLARGTIQTGVDT HHHHHCCEEECCCCC	12.35	26437602
457	Phosphorylation	GTKDTVCSGVTGAAN CCCCCCCCCCCCHHH	31.78	27251275
476	Phosphorylation	AVQGGLDTTKSVLTG HHCCCCCCCCHHHHC	40.96	-
477	O-linked_Glycosylation	VQGGLDTTKSVLTGT HCCCCCCCCHHHHCC	22.46	30379171
477	Phosphorylation	VQGGLDTTKSVLTGT HCCCCCCCCHHHHCC	22.46	17081983
479	Phosphorylation	GGLDTTKSVLTGTKD CCCCCCCHHHHCCHH	21.92	26437602
484	O-linked_Glycosylation	TKSVLTGTKDAVSTG CCHHHHCCHHHHHCC	22.10	30379171
489	Phosphorylation	TGTKDAVSTGLTGAV HCCHHHHHCCCCCCE	20.62	27251275
490	Phosphorylation	GTKDAVSTGLTGAVN CCHHHHHCCCCCCEE	29.61	27251275
512	Phosphorylation	TGVDTTKTVLTGTKD CCCCCCCEEEECCCC	20.75	26437602
526	O-linked_Glycosylation	DTVCSGVTSAVNVAK CCCCCCHHHHHHHHH	17.94	30379171
542	Phosphorylation	AVQGGLDTTKSVVIG HHHCCCCCCCEEEEE	40.96	26074081
543	Phosphorylation	VQGGLDTTKSVVIGT HHCCCCCCCEEEEEC	22.46	26074081
545	Phosphorylation	GGLDTTKSVVIGTKD CCCCCCCEEEEECCC	21.37	26657352
550	Phosphorylation	TKSVVIGTKDTMSTG CCEEEEECCCCCCCC	18.02	26074081
553	Phosphorylation	VVIGTKDTMSTGLTG EEEECCCCCCCCCCH	17.99	26074081
555	Phosphorylation	IGTKDTMSTGLTGAA EECCCCCCCCCCHHH	22.78	26074081
556	Phosphorylation	GTKDTMSTGLTGAAN ECCCCCCCCCCHHHH	25.95	26074081
559	Phosphorylation	DTMSTGLTGAANVAK CCCCCCCCHHHHHHH	26.56	26074081
571	Phosphorylation	VAKGAVQTGVDTAKT HHHHHHHCCCCCCHH	32.35	26074081
575	Phosphorylation	AVQTGVDTAKTVLTG HHHCCCCCCHHCCCC	27.87	26437602
578	Phosphorylation	TGVDTAKTVLTGTKD CCCCCCHHCCCCCCC	20.48	26437602
586	Phosphorylation	VLTGTKDTVTTGLVG CCCCCCCCCCCCCEE	22.70	-
589	Phosphorylation	GTKDTVTTGLVGAVN CCCCCCCCCCEEEEE	24.96	-
609	Phosphorylation	VQTGMDTTKTVLTGT EECCCCCCCEEEECC	22.06	-
611	Phosphorylation	TGMDTTKTVLTGTKD CCCCCCCEEEECCCC	20.75	26437602
614	Phosphorylation	DTTKTVLTGTKDTIY CCCCEEEECCCCCCC	38.17	-
621	Phosphorylation	TGTKDTIYSGVTSAV ECCCCCCCCCCHHHH	11.06	30576142
622	Phosphorylation	GTKDTIYSGVTSAVN CCCCCCCCCCHHHHH	23.96	22964224
625	Phosphorylation	DTIYSGVTSAVNVAK CCCCCCCHHHHHHHH	17.94	27251275
626	Phosphorylation	TIYSGVTSAVNVAKG CCCCCCHHHHHHHHH	28.01	27251275
677	Phosphorylation	TGVDTAKTVLTGTKD HCCCHHHHCCCCCCC	20.48	26437602
687	Phosphorylation	TGTKDTVTTGLMGAV CCCCCCCCCCHHCCC	19.76	-
700	O-linked_Glycosylation	AVNVAKGTVQTSVDT CCEECCCEEEEEECC	14.56	30379171
703	Phosphorylation	VAKGTVQTSVDTTKT ECCCEEEEEECCCCE	26.78	27251275
704	O-linked_Glycosylation	AKGTVQTSVDTTKTV CCCEEEEEECCCCEE	10.82	29407119
704	O-linked_Glycosylation	AKGTVQTSVDTTKTV CCCEEEEEECCCCEE	10.82	20068230
704	Phosphorylation	AKGTVQTSVDTTKTV CCCEEEEEECCCCEE	10.82	27251275
707	O-linked_Glycosylation	TVQTSVDTTKTVLTG EEEEEECCCCEEEEC	28.21	30379171
708	O-linked_Glycosylation	VQTSVDTTKTVLTGT EEEEECCCCEEEECC	21.91	30379171
710	Phosphorylation	TSVDTTKTVLTGTKD EEECCCCEEEECCCC	20.75	26437602
721	Phosphorylation	GTKDTVCSGVTGAAN CCCCCCCCCCCCHHH	31.78	27251275
741	Phosphorylation	IQGGLDTTKSVLTGT HHCCCCCCHHHHHCC	22.46	22210691
743	Phosphorylation	GGLDTTKSVLTGTKD CCCCCCHHHHHCCHH	21.92	17081983
746	Phosphorylation	DTTKSVLTGTKDAVS CCCHHHHHCCHHHHH	40.42	22210691
748	O-linked_Glycosylation	TKSVLTGTKDAVSTG CHHHHHCCHHHHHCC	22.10	30379171
757	Phosphorylation	DAVSTGLTGAVKLAK HHHHCCCCHHHHCCC	25.17	22210691
774	Phosphorylation	VQTGMDTTKTVLTGT EECCCCCCCEEEECC	22.06	-
774 (in isoform 2)	Phosphorylation	-	22.06	22210691
776	Phosphorylation	TGMDTTKTVLTGTKD CCCCCCCEEEECCCC	20.75	26437602
784 (in isoform 2)	Phosphorylation	-	13.03	22210691
787	Phosphorylation	GTKDAVCSGVTGAAN CCCCHHCCCCCCHHH	29.69	27251275
787 (in isoform 2)	Phosphorylation	-	29.69	22210691
809	Phosphorylation	MGVDTAKTVLTGTKD CCCCCCHHHCCCCCC	20.48	26437602
820	Phosphorylation	GTKDTVCSGVTGAAN CCCCCCCCCCCCHHH	31.78	27251275
872	Phosphorylation	AVQGGLDTTKSVLTG HHCCCCCCCHHHHHC	40.96	-
873	Phosphorylation	VQGGLDTTKSVLTGT HCCCCCCCHHHHHCC	22.46	17081983
875	Phosphorylation	GGLDTTKSVLTGTKD CCCCCCHHHHHCCHH	21.92	26437602
878	Phosphorylation	DTTKSVLTGTKDAVS CCCHHHHHCCHHHHH	40.42	23532336
880	O-linked_Glycosylation	TKSVLTGTKDAVSTG CHHHHHCCHHHHHCC	22.10	30379171
880	Phosphorylation	TKSVLTGTKDAVSTG CHHHHHCCHHHHHCC	22.10	23532336
885	Phosphorylation	TGTKDAVSTGLTGAV HCCHHHHHCCCCCHH	20.62	27251275
886	Phosphorylation	GTKDAVSTGLTGAVN CCHHHHHCCCCCHHH	29.61	27251275
889	Phosphorylation	DAVSTGLTGAVNLAK HHHHCCCCCHHHHCC	25.17	27251275
898	Phosphorylation	AVNLAKGTVQTGVDT HHHHCCCEEECCCCC	14.56	22673903
901	Phosphorylation	LAKGTVQTGVDTSKT HCCCEEECCCCCCCE	34.53	22673903
908	Phosphorylation	TGVDTSKTVLTGTKD CCCCCCCEEEECCCC	22.10	26437602
919	Phosphorylation	GTKDTVCSGVTGAVN CCCCCCCCCCCCCEE	31.78	23025827
951	O-linked_Glycosylation	SGAKDAVTTGVTGAV HCCHHHHHCCCCCCE	21.39	30379171
951	Phosphorylation	SGAKDAVTTGVTGAV HCCHHHHHCCCCCCE	21.39	-
985	Phosphorylation	GTKDTVFSGVTGAMS CCCCCCCCCHHHHHH	28.19	-
988	Phosphorylation	DTVFSGVTGAMSMAK CCCCCCHHHHHHHHH	23.81	23917254
992	Phosphorylation	SGVTGAMSMAKGAVQ CCHHHHHHHHHHHHC	18.30	27251275
1007	Phosphorylation	GGLDTTKTVLTGTKD CCCCCCCEEEECCHH	20.75	26437602
1012	Phosphorylation	TKTVLTGTKDAVSAG CCEEEECCHHHHHHC	22.10	-
1023	Phosphorylation	VSAGLMGSGNVATGA HHHCCCCCCCCCCCC	17.15	27251275
1048	Phosphorylation	WLPSTPATSWGGLTS CCCCCCCCCCCCCCC	26.64	27251275
1049	Phosphorylation	LPSTPATSWGGLTSS CCCCCCCCCCCCCCC	26.32	27251275
1076	Phosphorylation	SPQEAPFSGISTPPD CCCCCCCCCCCCCCC	33.87	27251275
1079	Phosphorylation	EAPFSGISTPPDVLS CCCCCCCCCCCCCCC	38.08	27251275
1080	Phosphorylation	APFSGISTPPDVLSV CCCCCCCCCCCCCCC	36.60	27251275
1104	Phosphorylation	ATTKGLATDVATFTQ HHCCCCCCHHHHHCC	35.73	23532336
1125	Phosphorylation	EDTGLLATTHGPEEA CCCCCEEECCCCCHH	21.21	27251275
1126	Phosphorylation	DTGLLATTHGPEEAP CCCCEEECCCCCHHH	21.16	27251275
1163	Phosphorylation	EQAQLAASQPGPKVL HHHHHHHCCCCCEEE	31.16	27251275
1171	Phosphorylation	QPGPKVLSAEQGSYF CCCCEEEEHHCCCEE	32.52	27251275
1187	Phosphorylation	RLGDLGPSFRQRAFE EECCCCHHHHHHHHH	31.12	27251275
1210	Phosphorylation	GQFQARDTLAQLQDC CCHHHHHHHHHHHHH	20.59	29978859
1238	Phosphorylation	QPRLDQGSGASAEDA CCCCCCCCCCCHHHH	26.08	22673903
1241	Phosphorylation	LDQGSGASAEDAAVQ CCCCCCCCHHHHHHH	35.40	22673903
1257	Phosphorylation	ERDAGVLSRVCGLLR HHHHHHHHHHHHHHH	21.91	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLIN4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLIN4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLIN4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMC3_HUMAN	SMC3	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.