PLIN2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLIN2_MOUSE
• UniProt AC: P43883
• Protein Name: Perilipin-2
• Gene Name: Plin2
• Organism: Mus musculus (Mouse).
• Sequence Length: 425
• Subcellular Localization: Membrane ; Peripheral membrane protein . Lipid droplet .
• Protein Description: May be involved in development and maintenance of adipose tissue..
• Protein Sequence: MAAAVVDPQQSVVMRVANLPLVSSTYDLVSSAYVSTKDQYPYLRSVCEMAEKGVKTVTSAAMTSALPIIQKLEPQIAVANTYACKGLDRMEERLPILNQPTSEIVASARGAVTGAKDVVTTTMAGAKDSVASTVSGVVDKTKGAVTGSVERTKSVVNGSINTVLGMVQFMNSGVDNAITKSELLVDQYFPLTQEELEMEAKKVEGFDMVQKPSNYERLESLSTKLCSRAYHQALSRVKEAKQKSQETISQLHSTVHLIEFARKNMHSANQKIQGAQDKLYVSWVEWKRSIGYDDTDESHCVEHIESRTLAIARNLTQQLQTTCQTVLVNAQGLPQNIQDQAKHLGVMAGDIYSVFRNAASFKEVSDGVLTSSKGQLQKMKESLDEVMDYFVNNTPLNWLVGPFYPQSTEVNKASLKVQQSEVKAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAVVDPQ ------CCCCCCCHH	12.25	-
11	Phosphorylation	AVVDPQQSVVMRVAN CCCCHHHCHHHHEEC	16.07	30635358
24	Phosphorylation	ANLPLVSSTYDLVSS ECCCEEECHHHHHHH	24.41	30352176
40	Phosphorylation	YVSTKDQYPYLRSVC CCCCCHHHHHHHHHH	12.18	23737553
42	Phosphorylation	STKDQYPYLRSVCEM CCCHHHHHHHHHHHH	15.15	23737553
45	Phosphorylation	DQYPYLRSVCEMAEK HHHHHHHHHHHHHHC	28.64	23737553
84	S-palmitoylation	AVANTYACKGLDRME HHCHHHHHCCHHHHH	2.24	28526873
85	Ubiquitination	VANTYACKGLDRMEE HCHHHHHCCHHHHHH	55.10	22790023
140	Ubiquitination	TVSGVVDKTKGAVTG HHHHCCCCCCCCCCC	40.29	22790023
201	Ubiquitination	EELEMEAKKVEGFDM HHHHHHHHHCCCCCC	44.01	22790023
211	Ubiquitination	EGFDMVQKPSNYERL CCCCCCCCCCCHHHH	38.72	22790023
213	Phosphorylation	FDMVQKPSNYERLES CCCCCCCCCHHHHHH	60.11	-
220	Phosphorylation	SNYERLESLSTKLCS CCHHHHHHHHHHHHH	32.01	27149854
224	Ubiquitination	RLESLSTKLCSRAYH HHHHHHHHHHHHHHH	44.09	22790023
253	Phosphorylation	ETISQLHSTVHLIEF HHHHHHHHHHHHHHH	40.49	22817900
254	Phosphorylation	TISQLHSTVHLIEFA HHHHHHHHHHHHHHH	10.95	19060867
271	Ubiquitination	NMHSANQKIQGAQDK HCHHHHHHHCCCCCH	36.48	22790023
280	Phosphorylation	QGAQDKLYVSWVEWK CCCCCHHEEEEHHHH	9.74	26643407
300	S-palmitoylation	DDTDESHCVEHIESR CCCCHHHHHHHHHHH	5.52	28526873
323	S-palmitoylation	TQQLQTTCQTVLVNA HHHHHHHHHHHHHCC	3.47	28526873
360	Phosphorylation	SVFRNAASFKEVSDG HHHHCCCCCCCCCCC	34.15	23140645
362	Ubiquitination	FRNAASFKEVSDGVL HHCCCCCCCCCCCCE	55.50	22790023
373	Ubiquitination	DGVLTSSKGQLQKMK CCCEECCHHHHHHHH	50.90	22790023
416	Ubiquitination	EVNKASLKVQQSEVK CCCHHHHHEEHHHHH	35.19	22790023
420	Phosphorylation	ASLKVQQSEVKAQ-- HHHHEEHHHHHCC--	27.54	30352176

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLIN2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLIN2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLIN2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PLIN2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.