PLEK_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLEK_MOUSE
• UniProt AC: Q9JHK5
• Protein Name: Pleckstrin
• Gene Name: Plek
• Organism: Mus musculus (Mouse).
• Sequence Length: 350
• Protein Description: Major protein kinase C substrate of platelets..
• Protein Sequence: MEPKRIREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQDFGKRMFVLKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEGGQKFARKSTRRSIRLPETIDLGALYLSMKDPEKGIKELNLEKDKKVFNHCLTGSGVIDWLVSNKLVRNRQEGLMISASLLSEGYLQPAGDLSKNAADGIAENPFLDSPDAFYYFPDSGFFCEENSSDDDVILREEFRGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGGEDPLGAVHLRGCVVTSVESSHDVKKSDEENLFEIITADEVHYYLQAATSKERTEWIKAIQVASRTGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Glutathionylation	GSTLTSPCQDFGKRM CCCCCCCCHHHCCCE	6.41	24333276
64	Acetylation	SPCQDFGKRMFVLKI CCCHHHCCCEEEEEE	40.46	-
101	Ubiquitination	RDIKKAIKCIEGGQK HHHHHHHHHHHHCHH	33.74	-
113	Phosphorylation	GQKFARKSTRRSIRL CHHHHCHHCCCCCCC	22.92	22817900
114	Phosphorylation	QKFARKSTRRSIRLP HHHHCHHCCCCCCCC	32.89	22817900
117	Phosphorylation	ARKSTRRSIRLPETI HCHHCCCCCCCCCEE	14.58	26824392
123	Phosphorylation	RSIRLPETIDLGALY CCCCCCCEEEECHHH	20.18	26745281
130	Phosphorylation	TIDLGALYLSMKDPE EEEECHHHHHCCCHH	9.01	25367039
132	Phosphorylation	DLGALYLSMKDPEKG EECHHHHHCCCHHHC	15.38	25367039
181	Phosphorylation	RQEGLMISASLLSEG CCCCCEEEHHHHCCC	9.61	25168779
183	Phosphorylation	EGLMISASLLSEGYL CCCEEEHHHHCCCCC	24.05	25168779
186	Phosphorylation	MISASLLSEGYLQPA EEEHHHHCCCCCCCC	33.98	25168779
189	Phosphorylation	ASLLSEGYLQPAGDL HHHHCCCCCCCCCCC	9.71	25168779
197	Phosphorylation	LQPAGDLSKNAADGI CCCCCCCCCCCCCCC	28.71	25168779
218	Phosphorylation	DSPDAFYYFPDSGFF CCCCCEEECCCCCCC	11.37	-
222	Phosphorylation	AFYYFPDSGFFCEEN CEEECCCCCCCCCCC	37.42	-
230	Phosphorylation	GFFCEENSSDDDVIL CCCCCCCCCCCCEEE	38.12	24224561
231	Phosphorylation	FFCEENSSDDDVILR CCCCCCCCCCCEEEC	57.55	24224561
250	Glutathionylation	GVIIKQGCLLKQGHR HEEEECCCCCCCCCC	3.59	24333276
274	Phosphorylation	ILREDPAYLHYYDPA EECCCCCEEEEECCC	10.21	-
277	Phosphorylation	EDPAYLHYYDPAGGE CCCCEEEEECCCCCC	13.63	26026062
278	Phosphorylation	DPAYLHYYDPAGGED CCCEEEEECCCCCCC	12.52	22817900
295	Glutathionylation	GAVHLRGCVVTSVES CCEEEECEEEEEEEC	1.47	24333276
298	Phosphorylation	HLRGCVVTSVESSHD EEECEEEEEEECCCC	13.47	30635358
299	Phosphorylation	LRGCVVTSVESSHDV EECEEEEEEECCCCC	16.57	30635358
302	Phosphorylation	CVVTSVESSHDVKKS EEEEEEECCCCCCCC	30.71	30635358
303	Phosphorylation	VVTSVESSHDVKKSD EEEEEECCCCCCCCC	15.36	30635358
325	Phosphorylation	ITADEVHYYLQAATS EEHHHHHHHHHHHCC	15.85	-
326	Phosphorylation	TADEVHYYLQAATSK EHHHHHHHHHHHCCH	4.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLEK_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLEK_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLEK_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PLEK_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.