PLDB1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLDB1_ARATH
• UniProt AC: P93733
• Protein Name: Phospholipase D beta 1 {ECO:0000303|PubMed:11891260}
• Gene Name: PLDBETA1 {ECO:0000303|PubMed:11891260}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1083
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein .
• Protein Description: Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA). Plays an important role in various cellular processes, including phytohormone action, vesicular trafficking, secretion, cytoskeletal arrangement, meiosis, tumor promotion, pathogenesis, membrane deterioration and senescence. Involved in regulating stomatal movement and plant-water status. [PubMed: 11722757 Can use phosphatidylserine (PS) and phosphatidylethanolamine (PE) as substrates only in the presence of PIP2. Can use phosphatidylcholine (PC), phosphatidylglycerol (PG) or N-acylphosphatidylethanolamine (NAPE) as substrates in the presence of PE and PIP2]
• Protein Sequence: MDNHGPRYPYPYGQYPYPYPYPAPYRPPSSEPYPPPPTNQYSAPYYPYPPPPYATPPPYASPPPPHQHTSGSHSGPLDYSHNPQPSSLAAAPPEYHRHSFDYQPSPYPYQPQGNFGAYGPPPPHYSYQEPAQYPPPETKPQEPLPPPQQTQGFQEYRRQDCLSTGGTGHDNVSNSGSSYPPVDELLGGLHISTNQPGPSVPQLSSLPSNSWQSRPGDLYGYPNSSFPSNSHLPQLGRVDSSSSYYASTESPHSADMQMTLFGKGSLKVLLLHGNLDIWIYHAKNLPNMDMFHKTLGDMFGRLPGKIEGQLTSKITSDPYVSVSVAGAVIGRTYVMSNSENPVWMQHFYVPVAHHAAEVHFVVKDSDVVGSQLIGLVTIPVEQIYSGAKIEGTYPILNSNGKPCKPGANLSLSIQYTPMDKLSVYHHGVGAGPDYQGVPGTYFPLRKGGTVRLYQDAHVPEGMLPGIRLDNGMSYEHGKCWHDMFDAIRQARRLIYITGWSVWHKVKLIRDKLGPASECTLGELLRSKSQEGVRVLLLIWDDPTSRSILGYKTDGVMATHDEETRRFFKHSSVQVLLCPRNAGKRHSWVKQREVGTIYTHHQKNVIVDADAGGNRRKIIAFVGGLDLCDGRYDTPQHPLFRTLQTIHKDDFHNPTFTGNLSGCPREPWHDLHSKIDGPAAYDVLTNFEERWLKAAKPSGIKKFKTSYDDALLRIDRIPDILGVSDTPTVSENDPEAWHVQIFRSIDSNSVKGFPKDPKDATCKNLVCGKNVLIDMSIHTAYVKAIRAAQHFIYIENQYFIGSSYNWNAHKDIGANNLIPMEIALKIAEKIRANERFAAYIVIPMWPEGVPTGAATQRILYWQHKTIQMMYETIYKALVETGLEGAFSPQDYLNFFCLGNREMVDGIDNSGTGSPSNANTPQALSRKSRRFMVYVHSKGMVVDDEYVVIGSANINQRSMEGTRDTEIAMGAYQPQHTWARKHSGPRGQIYGYRMSLWAEHMATLDDCFTQPESIECVRKVRTMGERNWKQFAAEEVSDMRGHLLKYPVEVDRKGKVRPLPGSETFPDVGGNIVGSFIAIQENLTI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
240	Phosphorylation	PQLGRVDSSSSYYAS CCCCCCCCCCCCEEC	29.30	27643528
241	Phosphorylation	QLGRVDSSSSYYAST CCCCCCCCCCCEECC	20.88	27643528
242	Phosphorylation	LGRVDSSSSYYASTE CCCCCCCCCCEECCC	26.72	27643528
243	Phosphorylation	GRVDSSSSYYASTES CCCCCCCCCEECCCC	24.90	27643528
244	Phosphorylation	RVDSSSSYYASTESP CCCCCCCCEECCCCC	12.66	30407730
245	Phosphorylation	VDSSSSYYASTESPH CCCCCCCEECCCCCC	8.95	30407730
247	Phosphorylation	SSSSYYASTESPHSA CCCCCEECCCCCCCC	19.31	30407730
248	Phosphorylation	SSSYYASTESPHSAD CCCCEECCCCCCCCC	32.10	30407730
250	Phosphorylation	SYYASTESPHSADMQ CCEECCCCCCCCCCC	28.18	30407730
253	Phosphorylation	ASTESPHSADMQMTL ECCCCCCCCCCCEEE	29.37	30407730
259	Phosphorylation	HSADMQMTLFGKGSL CCCCCCEEEECCCCE	11.31	30407730
321	Phosphorylation	ITSDPYVSVSVAGAV CCCCCCEEEEEECEE	11.66	28011693
323	Phosphorylation	SDPYVSVSVAGAVIG CCCCEEEEEECEEEC	9.95	28011693
526	Phosphorylation	TLGELLRSKSQEGVR CHHHHHHCCCCCCCE	36.31	24894044
528	Phosphorylation	GELLRSKSQEGVRVL HHHHHCCCCCCCEEE	34.41	24894044
672	Phosphorylation	EPWHDLHSKIDGPAA CCCHHHHHCCCCHHH	38.31	19880383
680	Phosphorylation	KIDGPAAYDVLTNFE CCCCHHHHHHHHHHH	14.53	19880383
684	Phosphorylation	PAAYDVLTNFEERWL HHHHHHHHHHHHHHH	37.40	19880383
908	Phosphorylation	MVDGIDNSGTGSPSN HCCCCCCCCCCCCCC	33.70	19880383
910	Phosphorylation	DGIDNSGTGSPSNAN CCCCCCCCCCCCCCC	34.02	19880383
912	Phosphorylation	IDNSGTGSPSNANTP CCCCCCCCCCCCCCH	25.62	19880383
914	Phosphorylation	NSGTGSPSNANTPQA CCCCCCCCCCCCHHH	50.72	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLDB1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLDB1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLDB1_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of PLDB1_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.