PLDA2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLDA2_ARATH
• UniProt AC: Q9SSQ9
• Protein Name: Phospholipase D alpha 2 {ECO:0000303|PubMed:11891260}
• Gene Name: PLDALPHA2 {ECO:0000303|PubMed:11891260}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 810
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein . Vacuole . Cytoplasmic vesicle, clathrin-coated vesicle . Found in vacuoles and also associated with plasma, microsomal and mitochondrial membranes and in clathrin-coated vesicles. Not found in chlo
• Protein Description: Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA). Plays an important role in various cellular processes, including phytohormone action and response to stress, characterized by acidification of the cell..
• Protein Sequence: MEECLLHGRLHATIYEVDHLHAEGGRSGFLGSILANVEETIGVGKGETQLYATIDLEKARVGRTRKITKEPKNPKWFESFHIYCGHMAKHVIFTVKDANPIGATLIGRGYIPVEDILHGEEVDRWVDILDNEKNPIAGGSKIHVKLQYFGVEKDKNWNRGIKSAKFPGVPYTFFSQRRGCKVSLYQDAHIPGNFVPKIPLAGGKNYEPHRCWEDIFDAITNAKHLIYITGWSVYTEISLVRDSRRPKQGGDVTVGELLKKKASEGVKVILLVWDDRTSVDLLKKDGLMATHDEETENFFRGTDVNCILCPRNPDDGGSIVQNLQISTMFTHHQKIVVVDSEMPSGGSRSRRIVSFVGGLDLCDGRYDTPFHSLFRTLDTAHHDDFHQPNFTGAAITKGGPREPWHDIHCRLEGPIAWDVLYNFEQRWSRQGGKDILVKMRELGDIIIPPSPVLFSEDHDVWNVQLFRSIDGGAAAGFPDSPEAAAEAGLVSGKDNIIDRSIQDAYIHAIRRAKDFIYIENQYFLGSSFAWSADGIKPEEINALHLIPKELSLKIVSKIKAGEKFKVYVVVPMWPEGIPESGSVQAILDWQKRTMEMMYKDVIKALRENGLEGEDPRDYLTFFCLGNREVKKDGEYEPSEKPEPDTDYIRAQEARRFMIYVHTKMMIVDDEYIIIGSANINQRSMDGARDSEIAMGGYQPYHLSTRQPARGQIHGFRMSLWYEHLGMLDETFLDPSSQECIQKVNRVADKYWDLYSSESLEHDLPGHLLRYPIGIASEGNITELPGCEFFPDTKARILGVKSDYMPPILTT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	IGVGKGETQLYATID CCCCCCCCEEEEEEE	32.32	19880383
290	Phosphorylation	KKDGLMATHDEETEN HHCCCCCCCCHHHCC	18.85	19880383
750	Phosphorylation	VNRVADKYWDLYSSE HHHHHHHHHHHCCCC	12.52	23776212
754	Phosphorylation	ADKYWDLYSSESLEH HHHHHHHCCCCCCCC	14.00	23776212
755	Phosphorylation	DKYWDLYSSESLEHD HHHHHHCCCCCCCCC	34.62	23776212
756	Phosphorylation	KYWDLYSSESLEHDL HHHHHCCCCCCCCCC	20.04	23776212
758	Phosphorylation	WDLYSSESLEHDLPG HHHCCCCCCCCCCCC	40.79	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLDA2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLDA2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLDA2_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of PLDA2_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.