PLCD1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLCD1_RAT
• UniProt AC: P10688
• Protein Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
• Gene Name: Plcd1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 756
• Protein Description: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development..
• Protein Sequence: MDSGRDFLTLHGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVQGLRKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDGYARKIFRECDHSQTDSLEDEEIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRAILGPILLDQPLDGVTTSLPSPEQLKGKILLKGKKLGGLLPAGGENGSEATDVSDEVEAAEMEDEAVRSQVQHKPKEDKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRHNVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPNTTFNSRALTQGPWWRPERLRVRIISGQQLPKVNKNKNSIVDPKVIVEIHGVGRDTGSRQTAVITNNGFNPRWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISIQD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	LLKVKSSSWRRERFY EEEECCCCHHHHHHH	31.52	22817900
191	Phosphorylation	IFRECDHSQTDSLED HHHHCCCCCCCCCCH	22.86	25575281
191	O-linked_Glycosylation	IFRECDHSQTDSLED HHHHCCCCCCCCCCH	22.86	24098488
193	Phosphorylation	RECDHSQTDSLEDEE HHCCCCCCCCCCHHH	30.48	25575281
193	O-linked_Glycosylation	RECDHSQTDSLEDEE HHCCCCCCCCCCHHH	30.48	24098488
195	Phosphorylation	CDHSQTDSLEDEEIE CCCCCCCCCCHHHHH	36.73	25575281
203	Phosphorylation	LEDEEIETFYKMLTQ CCHHHHHHHHHHHHH	37.62	25575281
209	Phosphorylation	ETFYKMLTQRAEIDR HHHHHHHHHHHHHHH	16.71	22817900
457	Phosphorylation	GENGSEATDVSDEVE CCCCCCCCCCCHHHH	32.65	-
460	Phosphorylation	GSEATDVSDEVEAAE CCCCCCCCHHHHHHH	30.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
35	S	Phosphorylation	Kinase	PRKCA	P17252	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLCD1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLCD1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PLCD1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.