PLCB1_BOVIN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLCB1_BOVIN
• UniProt AC: P10894
• Protein Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
• Gene Name: PLCB1
• Organism: Bos taurus (Bovine).
• Sequence Length: 1216
• Subcellular Localization: Nucleus membrane. Cytoplasm. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes..
• Protein Description: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes..
• Protein Sequence: MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWEDDSTVVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLDKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPIWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLMLPALFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARPTPAENGVNHTTSLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKTAKKDNKKKSEPSSPDHVSSTIEQDLAALDAEMTQKLVDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPLMTSDSGKLNQKPPSSEELEGENPGKEFDTPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	S-palmitoylation	ALQLKPVCVSDSLKK EEEEECEEEECHHCC	3.08	-
236	Phosphorylation	FSEFGAKSKPYLTVD HHHHCCCCCCEEEHH	38.03	-
417	Phosphorylation	SFENHVDSPKQQAKM EEECCCCCHHHHHHH	32.67	-
509	Phosphorylation	PGAGEADTESDDDDD CCCCCCCCCCCCCCC	44.42	-
511	Phosphorylation	AGEADTESDDDDDDD CCCCCCCCCCCCCCC	48.72	-
582	Phosphorylation	GLEQLTKSPVEFVEY CHHHHHCCCCCHHHH	29.01	-
887	Phosphorylation	HSQPAPGSVKAPAKT CCCCCCCCCCCCCCH	21.27	2211670
978	Phosphorylation	KKDNKKKSEPSSPDH CCCCCCCCCCCCCCH	64.72	-
987	Phosphorylation	PSSPDHVSSTIEQDL CCCCCHHHHHHHHHH	20.53	-
1199	Phosphorylation	KLNQKPPSSEELEGE CCCCCCCCHHHCCCC	59.93	-
1200	Phosphorylation	LNQKPPSSEELEGEN CCCCCCCHHHCCCCC	40.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
887	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
887	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
887	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLCB1_BOVIN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLCB1_BOVIN !!

Protein-Protein Interaction

Oops, there are no PPI records of PLCB1_BOVIN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Feedback regulation of phospholipase C-beta by protein kinase C.";
Ryu S.H., Kim U.H., Wahl M.I., Brown A.B., Carpenter G., Huang K.P.,Rhee S.G.;
J. Biol. Chem. 265:17941-17945(1990).
Cited for: PROTEIN SEQUENCE OF 879-889, AND PHOSPHORYLATION AT SER-887.
PubMed: 2211670