PKHM2_HUMAN - dbPTM
PKHM2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PKHM2_HUMAN
UniProt AC Q8IWE5
Protein Name Pleckstrin homology domain-containing family M member 2
Gene Name PLEKHM2
Organism Homo sapiens (Human).
Sequence Length 1019
Subcellular Localization Cytoplasm .
Protein Description May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation. [PubMed: 15905402 May play a role in lysosomes movement and localization at the cell periphery]
Protein Sequence MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDLSSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGDLTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQALDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSLGRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNGQLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGGHHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPVSEPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATMEKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEGTITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPHAFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLFTCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELDRLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEPGEVKD
-------CCCCHHHH		53.8622814378
7Ubiquitination-MEPGEVKDRILENI
-CCCCHHHHHHHHHC		36.67-
15PhosphorylationDRILENISLSVKKLQ
HHHHHHCCCCHHHHH		26.6124719451
20UbiquitinationNISLSVKKLQSYFAA
HCCCCHHHHHHHHHH		49.99-
250PhosphorylationDTVSGPRSTASDLTS
CCCCCCCCCHHHHCC		31.3027251275
253PhosphorylationSGPRSTASDLTSSKA
CCCCCCHHHHCCCCC		32.9926657352
256PhosphorylationRSTASDLTSSKASTR
CCCHHHHCCCCCCCC		35.6226074081
257PhosphorylationSTASDLTSSKASTRS
CCHHHHCCCCCCCCC		36.8226074081
258PhosphorylationTASDLTSSKASTRSP
CHHHHCCCCCCCCCC		27.3126074081
261PhosphorylationDLTSSKASTRSPTQR
HHCCCCCCCCCCCCC		28.2626074081
262PhosphorylationLTSSKASTRSPTQRQ
HCCCCCCCCCCCCCC		39.7726699800
264PhosphorylationSSKASTRSPTQRQNP
CCCCCCCCCCCCCCC		32.1825849741
266PhosphorylationKASTRSPTQRQNPFN
CCCCCCCCCCCCCCC		37.3226074081
279PhosphorylationFNEEPAETVSSSDTT
CCCCCCCCCCCCCCC		28.0022199227
281PhosphorylationEEPAETVSSSDTTPV
CCCCCCCCCCCCCCC		31.3825850435
282PhosphorylationEPAETVSSSDTTPVH
CCCCCCCCCCCCCCC		28.0925850435
283PhosphorylationPAETVSSSDTTPVHT
CCCCCCCCCCCCCCC		31.3222199227
285PhosphorylationETVSSSDTTPVHTTS
CCCCCCCCCCCCCCC		34.6422199227
286PhosphorylationTVSSSDTTPVHTTSQ
CCCCCCCCCCCCCCH		28.4422199227
290PhosphorylationSDTTPVHTTSQEKEE
CCCCCCCCCCHHHHH		28.5122199227
291PhosphorylationDTTPVHTTSQEKEEA
CCCCCCCCCHHHHHH		17.3422199227
292PhosphorylationTTPVHTTSQEKEEAQ
CCCCCCCCHHHHHHH		37.1822199227
327PhosphorylationKIGKKKKSRSDEEAS
CCCCCCCCCCCCCCC		45.9925159151
329PhosphorylationGKKKKSRSDEEASPL
CCCCCCCCCCCCCCC		57.3725159151
334PhosphorylationSRSDEEASPLHPACS
CCCCCCCCCCCHHHH		31.1325159151
341PhosphorylationSPLHPACSQKKCAKQ
CCCCHHHHHHHHHHC		47.3323401153
353PhosphorylationAKQGDGDSRNGSPSL
HHCCCCCCCCCCCCC		32.9225921289
357PhosphorylationDGDSRNGSPSLGRDS
CCCCCCCCCCCCCCC		18.1823401153
359PhosphorylationDSRNGSPSLGRDSPD
CCCCCCCCCCCCCCC		45.1923927012
364PhosphorylationSPSLGRDSPDTMLAS
CCCCCCCCCCCCCCC		24.2629255136
367PhosphorylationLGRDSPDTMLASPQE
CCCCCCCCCCCCCCC		19.9129255136
371PhosphorylationSPDTMLASPQEEGEG
CCCCCCCCCCCCCCC		24.1323663014
401PhosphorylationLIPEMKDTSMERLGQ
CCCCCCCCCHHHHCC		25.1822199227
402PhosphorylationIPEMKDTSMERLGQP
CCCCCCCCHHHHCCH		28.8722199227
436PhosphorylationRAEPPDQSFRTGSPG
CCCCCCCCCCCCCCC		24.8722199227
439PhosphorylationPPDQSFRTGSPGDAP
CCCCCCCCCCCCCCC		39.7525159151
441PhosphorylationDQSFRTGSPGDAPER
CCCCCCCCCCCCCCC		25.7025159151
455PhosphorylationRPPLCDFSEGLSAPM
CCCCCCCCCCCCCCC		19.9422199227
459PhosphorylationCDFSEGLSAPMDFYR
CCCCCCCCCCCCEEE		40.9822199227
465PhosphorylationLSAPMDFYRFTVESP
CCCCCCEEEEEEECC		10.6822199227
471PhosphorylationFYRFTVESPSTVTSG
EEEEEEECCCEECCC		21.5826074081
473PhosphorylationRFTVESPSTVTSGGG
EEEEECCCEECCCCC		44.8026074081
474PhosphorylationFTVESPSTVTSGGGH
EEEECCCEECCCCCC		31.0526074081
476PhosphorylationVESPSTVTSGGGHHD
EECCCEECCCCCCCC		23.0326074081
477PhosphorylationESPSTVTSGGGHHDP
ECCCEECCCCCCCCC		30.9826074081
495PhosphorylationGQPLHVPSSPEAAGQ
CCCCCCCCCHHHCCC		58.3926074081
496PhosphorylationQPLHVPSSPEAAGQE
CCCCCCCCHHHCCCC		22.2328464451
532PhosphorylationQELEAQLSLVREGPV
HHHHHHHHHHHCCCC		16.8529978859
554UbiquitinationQEVLCQLKRDQPSPC
HHHHHHHCCCCCCCC		28.22-
559PhosphorylationQLKRDQPSPCLSSAE
HHCCCCCCCCCCCCH		23.7023898821
563PhosphorylationDQPSPCLSSAEDSGV
CCCCCCCCCCHHCCC		33.9323663014
564PhosphorylationQPSPCLSSAEDSGVD
CCCCCCCCCHHCCCC		23.8023663014
568PhosphorylationCLSSAEDSGVDEGQG
CCCCCHHCCCCCCCC		32.0223663014
576PhosphorylationGVDEGQGSPSEMVHS
CCCCCCCCHHHHCCC		19.8427732954
578PhosphorylationDEGQGSPSEMVHSSE
CCCCCCHHHHCCCEE		39.7727732954
615PhosphorylationLFKMIRMSTGHMEGN
HHHHHHHHCCCCCCC		22.7623401153
616PhosphorylationFKMIRMSTGHMEGNL
HHHHHHHCCCCCCCH		23.0523401153
627PhosphorylationEGNLQLLYVLLTDCY
CCCHHHHHHHHHHHH		9.5423401153
631PhosphorylationQLLYVLLTDCYVYLL
HHHHHHHHHHHHHHH		21.6223401153
647PhosphorylationKGATEKPYLVEEAVS
CCCCCCCCEEEECCC		34.1518083107
655PhosphorylationLVEEAVSYNELDYVS
EEEECCCCCCCCEEE		13.1718083107
660PhosphorylationVSYNELDYVSVGLDQ
CCCCCCCEEEEECCH		13.7718083107
727UbiquitinationMEKLALAKFVAQESK
HHHHHHHHHHHHHCC		41.02-
733PhosphorylationAKFVAQESKCEASAV
HHHHHHHCCCCEEEE		30.4430576142
734UbiquitinationKFVAQESKCEASAVT
HHHHHHCCCCEEEEE		35.03-
738PhosphorylationQESKCEASAVTVRFY
HHCCCCEEEEEEEEE		10.8630576142
741PhosphorylationKCEASAVTVRFYGLV
CCCEEEEEEEEEEEE		12.9930576142
761PhosphorylationTDESLGPTPCHCSPP
CCCCCCCCCCCCCCC		36.4325627689
766PhosphorylationGPTPCHCSPPEGTIT
CCCCCCCCCCCCCCC		21.5925627689
781UbiquitinationKEGMLHYKAGTSYLG
CCCEEEEECCCCCCC		29.59-
789UbiquitinationAGTSYLGKEHWKTCF
CCCCCCCHHHHCEEE		43.75-
908PhosphorylationCHEDCQTSFFRSLGT
CCHHHHHHHHHHHCC		9.1224719451
917UbiquitinationFRSLGTAKLGDISAV
HHHHCCCCCCCEEEE		53.49-
922PhosphorylationTAKLGDISAVSTEPG
CCCCCCEEEEECCCC		27.6229083192
925PhosphorylationLGDISAVSTEPGKEY
CCCEEEEECCCCCEE		27.1129083192
926PhosphorylationGDISAVSTEPGKEYC
CCEEEEECCCCCEEE		39.3329083192
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PKHM2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PKHM2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PKHM2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PKHM2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PKHM2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-441, AND MASSSPECTROMETRY.

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