PKHH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PKHH1_HUMAN
• UniProt AC: Q9ULM0
• Protein Name: Pleckstrin homology domain-containing family H member 1
• Gene Name: PLEKHH1
• Organism: Homo sapiens (Human).
• Sequence Length: 1364
• Protein Sequence: MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLVPPYGAAEQDSVPSEPGIQPMGQDSGSQAQGLKAAVLAPSPGALQSKDSVSEAASPLEDSSSSTVHSGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLVTAQRGMLPGTKTSAREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSGLPELESRARSREEPEKMEMEEPPPAGKNEERESPKALGAELEEVELGNKPPTPPLHQFSSWESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTALKGRATQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSSYSTDGLGLGGESLEKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSLLEEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEVDRSCDSDEDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDGLYASLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRSETGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGSSTVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADMLTTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSILDHNTMQVHITYPYSSVTTFGGCRDDFMLVIRSIPDKSSGKSHIEKLIFRMAAPKIAEATFIMASYMNHCTTTVNPPTNPPGACQLWELDGRQFFSSVSCATKGPTLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	LKVEAPASVDWQKRC CEECCCCCCCHHHHH	21.39	-
81	Phosphorylation	SNLKNVDSEGSLHRK HHCCCCCCCCHHHHH	39.30	29255136
84	Phosphorylation	KNVDSEGSLHRKYQE CCCCCCCHHHHHHHH	19.56	29255136
99	Ubiquitination	LLKAIKGKDELISQL HHHHHCCHHHHHHHH	42.92	29967540
104	Phosphorylation	KGKDELISQLEAQLE CCHHHHHHHHHHHHH	41.14	-
219	Phosphorylation	KAAVLAPSPGALQSK EEEEECCCCCHHCCC	30.29	25159151
225	Phosphorylation	PSPGALQSKDSVSEA CCCCHHCCCCCHHCC	39.00	-
234	Phosphorylation	DSVSEAASPLEDSSS CCHHCCCCCCCCCCC	36.75	25159151
263	Phosphorylation	QPHLGRESPPHQPCM CCCCCCCCCCCCCCH	42.23	25159151
311	Phosphorylation	GGPGSSLTLPKVRAP CCCCCCCCCCCCCCC	42.85	23312004
320	Phosphorylation	PKVRAPGTPRDSIQL CCCCCCCCCHHHHHH	17.68	29523821
324	Phosphorylation	APGTPRDSIQLAKRH CCCCCHHHHHHHHHH	17.32	29523821
333	Phosphorylation	QLAKRHHSQPQVGHG HHHHHHCCCCCCCCC	37.11	27794612
393	Phosphorylation	GKNEERESPKALGAE CCCCCCCCCHHHCCC	37.61	26091039
426	Phosphorylation	SSWESRIYAVATSGM CCHHHHHHHHHCCCC	8.23	29978859
436	Phosphorylation	ATSGMRLSDMSPRSN HCCCCCHHHCCCCCC	22.39	30266825
456	Phosphorylation	SSPPALVSPGSFSGL CCCCCEECCCCCCCC	25.13	-
473	Phosphorylation	KNVTVPVYTALKGRA CCCCCCCCCCCCCCE	4.72	25159151
481	Phosphorylation	TALKGRATQISNMPF CCCCCCEEECCCCCC	25.69	30576142
492	Phosphorylation	NMPFMDESSGSDDDC CCCCCCCCCCCCCCC	35.42	30576142
501	Phosphorylation	GSDDDCSSQASFRIS CCCCCCCCCCEEEEE	35.78	30576142
508	Phosphorylation	SQASFRISVPSSESR CCCEEEEECCCCCCC	24.58	30266825
511	Phosphorylation	SFRISVPSSESRKTS EEEEECCCCCCCCCC	44.58	30266825
512	Phosphorylation	FRISVPSSESRKTSG EEEECCCCCCCCCCC	33.26	30266825
514	Phosphorylation	ISVPSSESRKTSGLG EECCCCCCCCCCCCC	40.81	30266825
517	Phosphorylation	PSSESRKTSGLGSPR CCCCCCCCCCCCCHH	27.24	-
522	Phosphorylation	RKTSGLGSPRAIKRG CCCCCCCCHHHHHCC	19.09	28102081
549	Phosphorylation	AIPPDACSLDSDYSE CCCCCCCCCCCCCCC	36.61	30576142
554	Phosphorylation	ACSLDSDYSEPEHKL CCCCCCCCCCCHHHC	20.91	30576142
564	Phosphorylation	PEHKLQRTSSYSTDG CHHHCCCCCCCCCCC	14.74	27251275
565	Phosphorylation	EHKLQRTSSYSTDGL HHHCCCCCCCCCCCC	29.48	23090842
566	Phosphorylation	HKLQRTSSYSTDGLG HHCCCCCCCCCCCCC	23.61	25159151
567	Phosphorylation	KLQRTSSYSTDGLGL HCCCCCCCCCCCCCC	18.50	23090842
568	Phosphorylation	LQRTSSYSTDGLGLG CCCCCCCCCCCCCCC	23.21	23090842
569	Phosphorylation	QRTSSYSTDGLGLGG CCCCCCCCCCCCCCH	26.34	23090842
578	Phosphorylation	GLGLGGESLEKSGYL CCCCCHHHHHHHCEE	45.14	23090842
582	Phosphorylation	GGESLEKSGYLLKMG CHHHHHHHCEEEECC	24.24	-
584	Phosphorylation	ESLEKSGYLLKMGSQ HHHHHHCEEEECCCC	18.89	-
590	O-linked_Glycosylation	GYLLKMGSQVKTWKR CEEEECCCCCCEEEC	28.44	30379171
594	Phosphorylation	KMGSQVKTWKRRWFV ECCCCCCEEECEEEE	37.04	24719451
638	Phosphorylation	QIVRGEGSQTFQLIS EEEECCCCCEEEEEE	23.03	28857561
640	Phosphorylation	VRGEGSQTFQLISEK EECCCCCEEEEEECC	18.29	28857561
645	Phosphorylation	SQTFQLISEKKTYYL CCEEEEEECCCEEEE	52.54	24719451
669	Phosphorylation	EWIRVLQSLLKVQAT HHHHHHHHHHHHHCC	31.35	24719451
716	Phosphorylation	LVGKIFYYYRSHEDK HHHHHHHHHHCCCCC	5.01	-
742	Phosphorylation	HIEEVDRSCDSDEDY HHHHHHHCCCCCCCC	20.15	23898821
745	Phosphorylation	EVDRSCDSDEDYEAG HHHHCCCCCCCCCCC	47.42	23898821
789	Phosphorylation	HEKDTWLYHLTVAAG CCCCCEEEEEEEECC	6.07	22210691
792	Phosphorylation	DTWLYHLTVAAGGSS CCEEEEEEEECCCCC	8.52	22210691
1080	Ubiquitination	MKELHPGKSEGGTRV HHHHCCCCCCCCCEE	50.19	29967540
1117	Phosphorylation	RLLLASQTSREIVAG HHHHHHHCCCHHHCC	27.53	-
1118	Phosphorylation	LLLASQTSREIVAGR HHHHHHCCCHHHCCC	21.93	-
1159	Phosphorylation	ALPGPGGTSPAKAQH CCCCCCCCCHHHHHH	37.14	25627689
1160	Phosphorylation	LPGPGGTSPAKAQHL CCCCCCCCHHHHHHH	26.57	25627689

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PKHH1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PKHH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PKHH1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PKHH1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.