PITM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PITM2_HUMAN
• UniProt AC: Q9BZ72
• Protein Name: Membrane-associated phosphatidylinositol transfer protein 2
• Gene Name: PITPNM2
• Organism: Homo sapiens (Human).
• Sequence Length: 1349
• Subcellular Localization: Endomembrane system ; Peripheral membrane protein .
• Protein Description: Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions..
• Protein Sequence: MIIKEYRIPLPMTVEEYRIAQLYMIQKKSRNETYGEGSGVEILENRPYTDGPGGSGQYTHKVYHVGMHIPSWFRSILPKAALRVVEESWNAYPYTRTRFTCPFVEKFSIDIETFYKTDAGENPDVFNLSPVEKNQLTIDFIDIVKDPVPHNEYKTEEDPKLFQSTKTQRGPLSENWIEEYKKQVFPIMCAYKLCKVEFRYWGMQSKIERFIHDTGLRRVMVRAHRQAWCWQDEWYGLSMENIRELEKEAQLMLSRKMAQFNEDGEEATELVKHEAVSDQTSGEPPEPSSSNGEPLVGRGLKKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDSDESSDDEFFDAHEDLSDTEEMFPKDITKWSSNDLMDKIESPEPEDTQDGLYRQGAPEFRVASSVEQLNIIEDEVSQPLAAPPSKIHVLLLVLHGGTILDTGAGDPSSKKGDANTIANVFDTVMRVHYPSALGRLAIRLVPCPPVCSDAFALVSNLSPYSHDEGCLSSSQDHIPLAALPLLATSSPQYQEAVATVIQRANLAYGDFIKSQEGMTFNGQVCLIGDCVGGILAFDALCYSNQPVSESQSSSRRGSVVSMQDNDLLSPGILMNAAHCCGGGGGGGGGGGSSGGGGSSGGSSLESSRHLSRSNVDIPRSNGTEDPKRQLPRKRSDSSTYELDTIQQHQAFLSSLHASVLRTEPCSRHSSSSTMLDGTGALGRFDFEITDLFLFGCPLGLVLALRKTVIPALDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQRGQRSMSVAAGCWGRAMTGRLEPGAAAGPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	YRIPLPMTVEEYRIA ECCCCCCCHHHHHHH	23.87	-
17	Phosphorylation	LPMTVEEYRIAQLYM CCCCHHHHHHHHHHE	8.20	-
23	Phosphorylation	EYRIAQLYMIQKKSR HHHHHHHHEEEECCC	4.70	-
59	Phosphorylation	PGGSGQYTHKVYHVG CCCCCCCCEEEEECC	13.82	12225667
155	Phosphorylation	VPHNEYKTEEDPKLF CCCCCCCCCCCCHHH	43.64	-
160	Ubiquitination	YKTEEDPKLFQSTKT CCCCCCCHHHHCCCC	74.40	-
191	Phosphorylation	VFPIMCAYKLCKVEF HHHHHHHHHHHHCHH	10.28	22817900
200	Phosphorylation	LCKVEFRYWGMQSKI HHHCHHHHHCCHHHH	16.19	25003641
214	Phosphorylation	IERFIHDTGLRRVMV HHHHHHHHCHHHHHH	24.77	23403867
254	Phosphorylation	KEAQLMLSRKMAQFN HHHHHHHHHHHHHHC	18.85	-
256	Ubiquitination	AQLMLSRKMAQFNED HHHHHHHHHHHHCCC	34.90	-
313	Phosphorylation	TSSKSSRSSKRGASP CCCCCCHHCCCCCCC	42.00	24719451
314	Phosphorylation	SSKSSRSSKRGASPS CCCCCHHCCCCCCCC	25.84	23663014
319	Phosphorylation	RSSKRGASPSRHSIS HHCCCCCCCCCCCCC	26.65	23401153
321	Phosphorylation	SKRGASPSRHSISEW CCCCCCCCCCCCCHH	39.88	23663014
324	Phosphorylation	GASPSRHSISEWRMQ CCCCCCCCCCHHHHH	27.05	25159151
326	Phosphorylation	SPSRHSISEWRMQSI CCCCCCCCHHHHHHH	33.84	23663014
337	Phosphorylation	MQSIARDSDESSDDE HHHHHCCCCCCCCHH	37.41	-
341	Phosphorylation	ARDSDESSDDEFFDA HCCCCCCCCHHHHHC	47.21	-
353	Phosphorylation	FDAHEDLSDTEEMFP HHCCCCCCCCHHHCC	55.60	-
355	Phosphorylation	AHEDLSDTEEMFPKD CCCCCCCCHHHCCCH	30.39	-
364	Phosphorylation	EMFPKDITKWSSNDL HHCCCHHHHCCHHHH	36.27	-
367	Phosphorylation	PKDITKWSSNDLMDK CCHHHHCCHHHHHHH	22.33	29514088
368	Phosphorylation	KDITKWSSNDLMDKI CHHHHCCHHHHHHHC	32.99	21815630
377	Phosphorylation	DLMDKIESPEPEDTQ HHHHHCCCCCCCCCC	37.73	21815630
383	Phosphorylation	ESPEPEDTQDGLYRQ CCCCCCCCCCCHHHC	27.22	28060719
388	Phosphorylation	EDTQDGLYRQGAPEF CCCCCCHHHCCCCCE	13.35	27642862
399	Phosphorylation	APEFRVASSVEQLNI CCCEEECCCHHHHCC	31.87	22199227
400	Phosphorylation	PEFRVASSVEQLNII CCEEECCCHHHHCCC	21.67	28464451
412	Phosphorylation	NIIEDEVSQPLAAPP CCCCCCCCCCCCCCH	24.84	28060719
589	Phosphorylation	QSSSRRGSVVSMQDN CCCCCCCCEEECCCC	19.96	-
642	Phosphorylation	LESSRHLSRSNVDIP HHCCCCHHHCCCCCC	27.77	23927012
644	Phosphorylation	SSRHLSRSNVDIPRS CCCCHHHCCCCCCCC	37.52	23401153
666	Phosphorylation	RQLPRKRSDSSTYEL CCCCCCCCCCCCCCH	44.90	28270605
668	Phosphorylation	LPRKRSDSSTYELDT CCCCCCCCCCCCHHH	26.31	22817900
669	Phosphorylation	PRKRSDSSTYELDTI CCCCCCCCCCCHHHH	39.74	30576142
670	Phosphorylation	RKRSDSSTYELDTIQ CCCCCCCCCCHHHHH	25.60	28270605
671	Phosphorylation	KRSDSSTYELDTIQQ CCCCCCCCCHHHHHH	19.22	28270605
675	Phosphorylation	SSTYELDTIQQHQAF CCCCCHHHHHHHHHH	33.05	30576142
689	Phosphorylation	FLSSLHASVLRTEPC HHHHHHHHHHCCCCC	15.78	30576142
700	Phosphorylation	TEPCSRHSSSSTMLD CCCCCCCCCCCCEEC	30.70	28857561
701	Phosphorylation	EPCSRHSSSSTMLDG CCCCCCCCCCCEECC	23.37	28857561
702	Phosphorylation	PCSRHSSSSTMLDGT CCCCCCCCCCEECCC	32.61	28857561
703	Phosphorylation	CSRHSSSSTMLDGTG CCCCCCCCCEECCCC	21.56	28857561
704	Phosphorylation	SRHSSSSTMLDGTGA CCCCCCCCEECCCCC	24.57	28857561
788	Phosphorylation	PPFSVPRYQRYPLGD CCCCCCCCCCCCCCC	7.41	-
798	Phosphorylation	YPLGDGCSTLLADVL CCCCCHHHHHHHHHH	27.85	28060719
799	Phosphorylation	PLGDGCSTLLADVLQ CCCCHHHHHHHHHHH	29.84	28060719
807	Phosphorylation	LLADVLQTHNAAFQE HHHHHHHHCHHHHHH	16.97	28060719
819	Phosphorylation	FQEHGAPSSPGTAPA HHHCCCCCCCCCCCC	48.94	28060719
820	Phosphorylation	QEHGAPSSPGTAPAS HHCCCCCCCCCCCCC	26.70	28060719
823	Phosphorylation	GAPSSPGTAPASRGF CCCCCCCCCCCCCCC	32.62	28060719
827	Phosphorylation	SPGTAPASRGFRRAS CCCCCCCCCCCHHHH	31.70	28060719
828	Methylation	PGTAPASRGFRRASE CCCCCCCCCCHHHHH	50.83	-
834	Phosphorylation	SRGFRRASEISIASQ CCCCHHHHHHHHHHH	33.38	26552605
837	Phosphorylation	FRRASEISIASQVSG CHHHHHHHHHHHHHC	14.19	26552605
840	Phosphorylation	ASEISIASQVSGMAE HHHHHHHHHHHCCCH	29.46	27251275
843	Phosphorylation	ISIASQVSGMAESYT HHHHHHHHCCCHHCC	18.40	26552605
848	Phosphorylation	QVSGMAESYTASSIA HHHCCCHHCCHHHHH	20.46	26552605
849	Phosphorylation	VSGMAESYTASSIAQ HHCCCHHCCHHHHHH	9.61	27251275
850	Phosphorylation	SGMAESYTASSIAQK HCCCHHCCHHHHHHH	29.37	26552605
852	Phosphorylation	MAESYTASSIAQKAP CCHHCCHHHHHHHCC	17.93	26552605
853	Phosphorylation	AESYTASSIAQKAPD CHHCCHHHHHHHCCH	21.34	26552605
863	Phosphorylation	QKAPDALSHTPSVRR HHCCHHHHCCCCCCE	27.34	23186163
865	Phosphorylation	APDALSHTPSVRRLS CCHHHHCCCCCCEEE	17.55	30266825
867	Phosphorylation	DALSHTPSVRRLSLL HHHHCCCCCCEEEEE	29.43	30266825
872	Phosphorylation	TPSVRRLSLLALPAP CCCCCEEEEEECCCC	21.37	29255136
880	Phosphorylation	LLALPAPSPTTPGPH EEECCCCCCCCCCCC	36.66	22199227
882	Phosphorylation	ALPAPSPTTPGPHPP ECCCCCCCCCCCCCC	50.38	22199227
883	Phosphorylation	LPAPSPTTPGPHPPA CCCCCCCCCCCCCCC	29.63	22199227
894	Phosphorylation	HPPARKASPGLERAP CCCCCCCCCCCCCCC	23.64	25159151
955	Phosphorylation	WESTDVVSFLLRQVM HCHHHHHHHHHHHHH	15.27	24719451
967	Phosphorylation	QVMRHDNSSILELDG HHHCCCCCCEEEECC	25.47	27134283
978	Phosphorylation	ELDGKEVSVFTPSKP EECCEEEEEECCCCC	16.77	30576142
981	Phosphorylation	GKEVSVFTPSKPREK CEEEEEECCCCCHHH	25.21	28674419
1057	Phosphorylation	GEWLYLDTLVTNNSG CCEEEEEEEEECCCC	22.12	30576142
1063	Phosphorylation	DTLVTNNSGRVSYTI EEEEECCCCCEEEEC	30.00	30576142
1068	Phosphorylation	NNSGRVSYTIPESHR CCCCCEEEECCHHHC	13.06	22210691
1149	Phosphorylation	DLGYLIIYVTGRPDM HCCEEEEEEECCCHH	5.74	-
1217	Phosphorylation	STKDVAVYSAISLSP CCHHHHHEEEEECCC	5.22	-
1277	Phosphorylation	RMALRKGSFGLPGQG HHHHHHCCCCCCCCC	21.12	26846344
1296	Phosphorylation	SRNHLLRTISAQPSG HCCHHHHHHHCCCCC	21.18	28060719
1298	Phosphorylation	NHLLRTISAQPSGPS CHHHHHHHCCCCCCC	21.90	28857561
1324	Phosphorylation	GEQRGQRSMSVAAGC HHHHHHHHHHHHHHC	13.92	28122231
1326	Phosphorylation	QRGQRSMSVAAGCWG HHHHHHHHHHHHCCC	15.17	29978859
1337	Phosphorylation	GCWGRAMTGRLEPGA HCCCHHHCCCCCCCC	20.40	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PITM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PITM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PITM2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PITM2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.