PIPNA_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIPNA_RAT
• UniProt AC: P16446
• Protein Name: Phosphatidylinositol transfer protein alpha isoform
• Gene Name: Pitpna
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 271
• Subcellular Localization: Cytoplasm.
• Protein Description: Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes..
• Protein Sequence: MVLLKEYRVILPVSVDEYQVGQLYSVAEASKNETGGGEGVEVLVNEPYEKDDGEKGQYTHKIYHLQSKVPTFVRMLAPEGALNIHEKAWNAYPYCRTVITNEYMKEDFLIKIETWHKPDLGTQENVHKLEPEAWKHVEAIYIDIADRSQVLSKDYKAEEDPAKFKSIKTGRGPLGPNWKQELVNQKDCPYMCAYKLVTVKFKWWGLQNKVENFIHKQEKRLFTNFHRQLFCWLDKWVDLTMDDIRRMEEETKRQLDEMRQKDPVKGMTADD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Acetylation	---MVLLKEYRVILP ---CCEEEEEEEEEE	48.84	22902405
50	Acetylation	LVNEPYEKDDGEKGQ EECCCCCCCCCCCCC	56.10	22902405
59	Phosphorylation	DGEKGQYTHKIYHLQ CCCCCCEEHHHEEHH	14.59	15322105
68	Ubiquitination	KIYHLQSKVPTFVRM HHEEHHHCCCCHHHH	38.99	-
87	Ubiquitination	GALNIHEKAWNAYPY CCCCHHHHHHHHCCC	44.53	-
105	Ubiquitination	VITNEYMKEDFLIKI EECCCHHHHCEEEEE	53.91	-
111	Ubiquitination	MKEDFLIKIETWHKP HHHCEEEEEEECCCC	36.32	-
153	Acetylation	DRSQVLSKDYKAEED HHHHHHCCCCCCCCC	62.00	22902405
153	Ubiquitination	DRSQVLSKDYKAEED HHHHHHCCCCCCCCC	62.00	-
163	Acetylation	KAEEDPAKFKSIKTG CCCCCHHHCCCCCCC	59.73	22902405
166	Phosphorylation	EDPAKFKSIKTGRGP CCHHHCCCCCCCCCC	32.24	15322105
200	Acetylation	AYKLVTVKFKWWGLQ EEEEEEEEHHHHHCH	31.68	22902405
202	Acetylation	KLVTVKFKWWGLQNK EEEEEEHHHHHCHHH	36.00	22902405
202	Ubiquitination	KLVTVKFKWWGLQNK EEEEEEHHHHHCHHH	36.00	-
209	Acetylation	KWWGLQNKVENFIHK HHHHCHHHHHHHHHH	37.66	22902405
216	Acetylation	KVENFIHKQEKRLFT HHHHHHHHHHHHHHH	56.17	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
59	T	Phosphorylation	Kinase	PRKCA	P05696	GPS
59	T	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
166	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
166	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIPNA_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIPNA_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PIPNA_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.