PILRB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PILRB_HUMAN
• UniProt AC: Q9UKJ0
• Protein Name: Paired immunoglobulin-like type 2 receptor beta
• Gene Name: PILRB
• Organism: Homo sapiens (Human).
• Sequence Length: 227
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface..
• Protein Sequence: MGRPLLLPLLLLLQPPAFLQPGGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELAIVPNVRISWRRGHFHGQSFYSTRPPSIHKDYVNRLFLNWTEGQESGFLRISNLRKEDQSVYFCRVELDTRRSGRQQLQSIKGTKLTITQAVTTTTTWRPSSTTTIAGLRVTESKGHSESWHLSLDTAIRVALAVAVLKTVILGLLCLLLLWWRRRKGSRAPSSDF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24 (in isoform 3)	Phosphorylation	-	35.19	23927012
24	Phosphorylation	AFLQPGGSTGSGPSY CCCCCCCCCCCCCCC	35.19	24043423
25	Phosphorylation	FLQPGGSTGSGPSYL CCCCCCCCCCCCCCE	38.35	24043423
27 (in isoform 3)	Phosphorylation	-	47.85	23927012
27	Phosphorylation	QPGGSTGSGPSYLYG CCCCCCCCCCCCEEE	47.85	24043423
30	Phosphorylation	GSTGSGPSYLYGVTQ CCCCCCCCCEEEECC	31.15	24043423
31	Phosphorylation	STGSGPSYLYGVTQP CCCCCCCCEEEECCC	13.69	24043423
33	Phosphorylation	GSGPSYLYGVTQPKH CCCCCCEEEECCCCE	11.00	24043423
36	Phosphorylation	PSYLYGVTQPKHLSA CCCEEEECCCCEEEC	34.49	24043423
45 (in isoform 3)	Phosphorylation	-	7.63	30631047
70	Phosphorylation	IVPNVRISWRRGHFH EECCEEEEEECCCCC	12.17	24719451
81 (in isoform 3)	Phosphorylation	-	4.25	22617229
83	Phosphorylation	FHGQSFYSTRPPSIH CCCCCCCCCCCCCCC	18.87	-
84	Phosphorylation	HGQSFYSTRPPSIHK CCCCCCCCCCCCCCH	35.50	-
88	Phosphorylation	FYSTRPPSIHKDYVN CCCCCCCCCCHHHHH	39.75	-
100	N-linked_Glycosylation	YVNRLFLNWTEGQES HHHHHCCCCCCCCCC	35.97	UniProtKB CARBOHYD
113	Phosphorylation	ESGFLRISNLRKEDQ CCCEEEEECCCHHCC	24.31	24719451
121	Phosphorylation	NLRKEDQSVYFCRVE CCCHHCCEEEEEEEE	30.98	22210691
141	Phosphorylation	SGRQQLQSIKGTKLT CHHHHHHHCCCCEEE	34.56	29083192
145	Phosphorylation	QLQSIKGTKLTITQA HHHHCCCCEEEEEEE	20.20	29083192
148	Phosphorylation	SIKGTKLTITQAVTT HCCCCEEEEEEEEEE	24.43	-
156	Phosphorylation	ITQAVTTTTTWRPSS EEEEEEECCEECCCC	16.92	-
157	Phosphorylation	TQAVTTTTTWRPSST EEEEEECCEECCCCC	23.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PILRB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PILRB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PILRB_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PILRB_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.