PIE1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIE1_ARATH
• UniProt AC: Q7X9V2
• Protein Name: Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1
• Gene Name: PIE1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 2055
• Subcellular Localization: Nucleus .
• Protein Description: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.F/Z leading to transcriptional regulation of selected genes (e.g. FLC) by chromatin remodeling. Probable DNA-dependent ATPase. Not involved in the repression of FLC in gametophytes, but required for the reactivation of FLC in early embryos and for the maintenance of full activation of FLC in late embryos..
• Protein Sequence: MASKGGKSKPDIVMASKSGKSKPDNESRAKRQKTLEAPKEPRRPKTHWDHVLEEMAWLSKDFESERKWKLAQAKKVALRASKGMLDQASREERKLKEEEQRLRKVALNISKDMKKFWMKVEKLVLYKHQLVRNEKKKKAMDKQLEFLLGQTERYSTMLAENLVEPYKQGQNTPSKPLLTIESKSDEERAEQIPPEINSSAGLESGSPELDEDYDLKSEDETEDDEDTIEEDEKHFTKRERQEELEALQNEVDLPVEELLRRYTSGRVSRETSPVKDENEDNLTSVSRVTSPVKDENQDNLASVGQDHGEDKNNLAASEETEGNPSVRRSNDSYGHLAISETHSHDLEPGMTTASVKSRKEDHTYDFNDEQEDVDFVLANGEEKDDEATLAVEEELAKADNEDHVEEIALLQKESEMPIEVLLARYKEDFGGKDISEDESESSFAVSEDSIVDSDENRQQADLDDDNVDLTECKLDPEPCSENVEGTFHEVAEDNDKDSSDKIADAAAAARSAQPTGFTYSTTKVRTKLPFLLKHSLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIMTIALLAHLACDKGIWGPHLIVVPTSVMLNWETEFLKWCPAFKILTYFGSAKERKLKRQGWMKLNSFHVCITTYRLVIQDSKMFKRKKWKYLILDEAHLIKNWKSQRWQTLLNFNSKRRILLTGTPLQNDLMELWSLMHFLMPHVFQSHQEFKDWFCNPIAGMVEGQEKINKEVIDRLHNVLRPFLLRRLKRDVEKQLPSKHEHVIFCRLSKRQRNLYEDFIASTETQATLTSGSFFGMISIIMQLRKVCNHPDLFEGRPIVSSFDMAGIDVQLSSTICSLLLESPFSKVDLEALGFLFTHLDFSMTSWEGDEIKAISTPSELIKQRVNLKDDLEAIPLSPKNRKNLQGTNIFEEIRKAVFEERIQESKDRAAAIAWWNSLRCQRKPTYSTSLRTLLTIKGPLDDLKANCSSYMYSSILADIVLSPIERFQKMIELVEAFTFAIPAARVPSPTCWCSKSDSPVFLSPSYKEKVTDLLSPLLSPIRPAIVRRQVYFPDRRLIQFDCGKLQELAMLLRKLKFGGHRALIFTQMTKMLDVLEAFINLYGYTYMRLDGSTPPEERQTLMQRFNTNPKIFLFILSTRSGGVGINLVGADTVIFYDSDWNPAMDQQAQDRCHRIGQTREVHIYRLISESTIEENILKKANQKRVLDNLVIQNGEYNTEFFKKLDPMELFSGHKALTTKDEKETSKHCGADIPLSNADVEAALKQAEDEADYMALKRVEQEEAVDNQEFTEEPVERPEDDELVNEDDIKADEPADQGLVAAGPAKEEMSLLHSDIRDERAVITTSSQEDDTDVLDDVKQMAAAAADAGQAISSFENQLRPIDRYAIRFLELWDPIIVEAAMENEAGFEEKEWELDHIEKYKEEMEAEIDDGEEPLVYEKWDADFATEAYRQQVEVLAQHQLMEDLENEAREREAAEVAEMVLTQNESAHVLKPKKKKKAKKAKYKSLKKGSLAAESKHVKSVVKIEDSTDDDNEEFGYVSSSDSDMVTPLSRMHMKGKKRDLIVDTDEEKTSKKKAKKHKKSLPNSDIKYKQTSALLDELEPSKPSDSMVVDNELKLTNRGKTVGKKFITSMPIKRVLMIKPEKLKKGNLWSRDCVPSPDSWLPQEDAILCAMVHEYGPNWNFVSGTLYGMTAGGAYRGRYRHPAYCCERYRELIQRHILSASDSAVNEKNLNTGSGKALLKVTEENIRTLLNVAAEQPDTEMLLQKHFSCLLSSIWRTSTRTGNDQMLSLNSPIFNRQFMGSVNHTQDLARKPWQGMKVTSLSRKLLESALQDSGPSQPDNTISRSRLQETQPINKLGLELTLEFPRGNDDSLNQFPPMISLSIDGSDSLNYVNEPPGEDVLKGSRVAAENRYRNAANACIEDSFGWASNTFPANDLKSRTGTKAQSLGKHKLSASDSAKSTKSKHRKLLAEQLEGAWVRPNDPNLKFDFTPGDREEEEEQEVDEKANSAEIEMISCSQWYDPFFTSGLDDCSLASDISEIE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
179	Phosphorylation	TPSKPLLTIESKSDE CCCCCCEEEECCCHH		25561503
182	Phosphorylation	KPLLTIESKSDEERA CCCEEEECCCHHHHH		25561503
184	Phosphorylation	LLTIESKSDEERAEQ CEEEECCCHHHHHHH		25561503
262	Phosphorylation	VEELLRRYTSGRVSR HHHHHHHHHCCCCCC		25561503
263	Phosphorylation	EELLRRYTSGRVSRE HHHHHHHHCCCCCCC		25561503
264	Phosphorylation	ELLRRYTSGRVSRET HHHHHHHCCCCCCCC		25561503
268	Phosphorylation	RYTSGRVSRETSPVK HHHCCCCCCCCCCCC		29654922
271	Phosphorylation	SGRVSRETSPVKDEN CCCCCCCCCCCCCCC		23776212
272	Phosphorylation	GRVSRETSPVKDENE CCCCCCCCCCCCCCC		23776212
283	Phosphorylation	DENEDNLTSVSRVTS CCCCCCCCEEEEECC		23776212
284	Phosphorylation	ENEDNLTSVSRVTSP CCCCCCCEEEEECCC		23776212
286	Phosphorylation	EDNLTSVSRVTSPVK CCCCCEEEEECCCCC		23776212
289	Phosphorylation	LTSVSRVTSPVKDEN CCEEEEECCCCCCCC		30407730
290	Phosphorylation	TSVSRVTSPVKDENQ CEEEEECCCCCCCCC		30407730
388	Phosphorylation	EEKDDEATLAVEEEL CCCCHHHHHHHHHHH		19880383
909	Phosphorylation	DLEAIPLSPKNRKNL HHHCCCCCHHCCCCC		30291188
1355	Phosphorylation	RDERAVITTSSQEDD CCCCEEEECCCCCCC		23776212
1356	Phosphorylation	DERAVITTSSQEDDT CCCEEEECCCCCCCC		23776212
1357	Phosphorylation	ERAVITTSSQEDDTD CCEEEECCCCCCCCC		30291188
1358	Phosphorylation	RAVITTSSQEDDTDV CEEEECCCCCCCCCH		23776212
1363	Phosphorylation	TSSQEDDTDVLDDVK CCCCCCCCCHHHHHH		23776212
1578	Phosphorylation	KRDLIVDTDEEKTSK CCCEECCCCHHHHHH		30291188
1802	Phosphorylation	TGNDQMLSLNSPIFN CCCCCEEECCCCCCC		19880383
1805	Phosphorylation	DQMLSLNSPIFNRQF CCEEECCCCCCCCCC		27531888

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIE1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIE1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIE1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H2AV3_ARATH	HTA9	physical	17988222
H2AV2_ARATH	HTA8	physical	17988222
H2AV1_ARATH	HTA11	physical	17988222

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.