PHTF_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHTF_DROME
• UniProt AC: Q9V9A8
• Protein Name: Putative homeodomain transcription factor
• Gene Name: phtf
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 880
• Subcellular Localization: Nucleus .
• Protein Description: May play a role in transcription regulation..
• Protein Sequence: MKLDEIVAWYQKRIGTYDKQEWEKTVEQRILDGFNSVNLKNTKLKTELIDVDLVRGSTFPKAKPKQSLLTVIRLAILRYVLLPLYAQWWVKQTTPNAFGFILVLYLTQLTNWAIYVLHSSRIVPLDYEKPPNGTLLQAEADGDASDKDADKESEEHAALLSALLIPCALSLLISLIHSQIVATNTASGVSGGSSKNKLRRISASYLSDKAATRENRVRRRKKIVRVRQVEADLSQASSNISLPNRRTATSTIEVLPRPVTPLPSPTVTCATVPDPTTPTTPSPSVIRRSTNEETYLTTTAISPLTQPLAAIDACYDLSRKAGGAAPESPKKRNVNWHTPIQIYATYELGEEPCSSRKVAEESAPESVGERLCSVKPDYQTRRNIGEDDGFESLNGKSSSGEDNNHSPLPNAVAVAAPPAPVQTNQLRLRLNTTNGVTASASPTEKKPQSRGNESSTSCAESDECDDADIMSSPASGCNQECTTSATDWLGVTTNSEDCSYTSDLDHSDGGLKHTAFSDEDPGELDITPTTILNPHSSLDRISCTIWDQRDAKKAQLSVLEIASCIIERVDSMGEANDYIYIGVVFSFLLTLIPIFCRLCEVTLGSDAEKASEISYFNMPQLLWEKSSASLFTLLGLAFGDSQWERMVLALGFVQRLCLTLILFIIFAVAERTFKQRFLYAKLFSHLTSSRRARKSNLPHFRLNKVRNIKTWLSVRSYLKKRGPQRSVDIIVSAAFIVTLLLLAFLSVEWLKDSAHLHTHLTLEALIWSITIGIFLLRFMTLGQKIQHKYRSVSVLITEQINLYLQIEQKPKKKDELMVSNSVLKLAADLLKELETPFKLSGLSANPYLFTTIKVVILSALSGVLSEVLGFKLKLHKIKIK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
132	N-linked_Glycosylation	LDYEKPPNGTLLQAE CCCCCCCCCCEEEEE	65.69	-
202	Phosphorylation	KNKLRRISASYLSDK HHHHHHHCHHHHCHH	14.89	19429919
239	N-linked_Glycosylation	DLSQASSNISLPNRR CHHHHHCCCCCCCCC	25.93	-
328	Phosphorylation	AGGAAPESPKKRNVN CCCCCCCCCCCCCCC	40.74	27794539
431	N-linked_Glycosylation	NQLRLRLNTTNGVTA CEEEEEEECCCCCCC	38.12	-
452	N-linked_Glycosylation	KKPQSRGNESSTSCA CCCCCCCCCCCCCHH	44.88	-
514	Phosphorylation	SDGGLKHTAFSDEDP CCCCCCCCEECCCCC	28.01	19429919
517	Phosphorylation	GLKHTAFSDEDPGEL CCCCCEECCCCCCCC	37.31	19429919
527	Phosphorylation	DPGELDITPTTILNP CCCCCCCCCCEECCC	17.78	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHTF_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHTF_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHTF_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517 AND THR-527, ANDMASS SPECTROMETRY.
PubMed: 18327897