PHOS_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHOS_RAT
• UniProt AC: P20942
• Protein Name: Phosducin
• Gene Name: Pdc
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 246
• Subcellular Localization: Cytoplasm, cytosol . Nucleus . Cell projection, cilium, photoreceptor outer segment . Photoreceptor inner segment .
• Protein Description: Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism..
• Protein Sequence: MEEAASQSLEEDFEGQATHTGPKGVINDWRKFKLESEDGDSIPPSKKEILRQMSSPQSRDDKDSKERMSRKMSIQEYELIHQDKEDEGCLRKYRRQCMQDMHQKLSFGPRYGFVYELETGEQFLETIEKEQKVTTIVVNIYEDGVRGCDALNSSLECLAAEYPMVKFCKIRASNTGAGDRFSSDVLPTLLVYKGGELISNFISVAEQFAEDFFAADVESFLNEYGLLPEREIHDLGQTNTEDEDIE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MEEAASQSLEEDF --CHHHHHHHHHHHH	27.61	11331285
36	Phosphorylation	WRKFKLESEDGDSIP CHHEECCCCCCCCCC	51.96	22817900
54	Phosphorylation	KEILRQMSSPQSRDD HHHHHHHCCCCCCCC	30.44	22817900
73	Phosphorylation	ERMSRKMSIQEYELI HHHHHHHHHHHHHHH	24.93	2394752
106	Phosphorylation	QDMHQKLSFGPRYGF HHHHHHHCCCCCCEE	34.88	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
6	S	Phosphorylation	Kinase	CAMK2A	P11798	PSP
36	S	Phosphorylation	Kinase	CAMK2A	P11798	PSP
54	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
54	S	Phosphorylation	Kinase	CAMK2A	P11798	PSP
73	S	Phosphorylation	Kinase	PKACA	P00517	PSP
73	S	Phosphorylation	Kinase	PKACA	P17612	PSP
73	S	Phosphorylation	Kinase	PRKACA	P27791	GPS
73	S	Phosphorylation	Kinase	CAMK2A	P11798	PSP
73	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
73	S	Phosphorylation	Kinase	PKA	-	Uniprot
73	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
106	S	Phosphorylation	Kinase	CAMK2A	P11798	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHOS_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHOS_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PHOS_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Analysis of the human, bovine and rat 33-kDa proteins and cDNA inretina and pineal gland.";
Abe T., Nakabayashi H., Tamada H., Takagi T., Sakuragi S., Yamaki K.,Shinohara T.;
Gene 91:209-215(1990).
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
PubMed: 2210381