PHOS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHOS_HUMAN
• UniProt AC: P20941
• Protein Name: Phosducin
• Gene Name: PDC
• Organism: Homo sapiens (Human).
• Sequence Length: 246
• Subcellular Localization: Cytoplasm, cytosol . Nucleus . Cell projection, cilium, photoreceptor outer segment . Photoreceptor inner segment .; Isoform 2: Nucleus .
• Protein Description: May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX..
• Protein Sequence: MEEAKSQSLEEDFEGQATHTGPKGVINDWRKFKLESQDSDSIPPSKKEILRQMSSPQSRNGKDSKERVSRKMSIQEYELIHKEKEDENCLRKYRRQCMQDMHQKLSFGPRYGFVYELETGKQFLETIEKELKITTIVVHIYEDGIKGCDALNSSLTCLAAEYPIVKFCKIKASNTGAGDRFSLDVLPTLLIYKGGELISNFISVAEQFAEEFFAGDVESFLNEYGLLPEREVHVLEHTKIEEEDVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 2)	Phosphorylation	-	67.66	11331285
33	Sumoylation	INDWRKFKLESQDSD CCCCHHEECCCCCCC	55.14	-
36	Phosphorylation	WRKFKLESQDSDSIP CHHEECCCCCCCCCC	50.12	-
54	Phosphorylation	KEILRQMSSPQSRNG HHHHHHHCCCCCCCC	30.44	27174698
55	Phosphorylation	EILRQMSSPQSRNGK HHHHHHCCCCCCCCC	22.93	27174698
58	Phosphorylation	RQMSSPQSRNGKDSK HHHCCCCCCCCCCHH	30.97	27174698
62	Acetylation	SPQSRNGKDSKERVS CCCCCCCCCHHHHHH	63.48	7963347
64	Phosphorylation	QSRNGKDSKERVSRK CCCCCCCHHHHHHHH	39.64	27174698
65	Acetylation	SRNGKDSKERVSRKM CCCCCCHHHHHHHHH	60.72	7963355
73	Phosphorylation	ERVSRKMSIQEYELI HHHHHHHHHHHHHHH	24.93	2394752
111	Phosphorylation	KLSFGPRYGFVYELE HHCCCCCCEEEEEEC	20.32	30576142
115	Phosphorylation	GPRYGFVYELETGKQ CCCCEEEEEECCCHH	16.73	30576142
119	Phosphorylation	GFVYELETGKQFLET EEEEEECCCHHHHHH	63.40	30576142
134	Phosphorylation	IEKELKITTIVVHIY HHHHHCCEEEEEEEE	14.64	22210691
135	Phosphorylation	EKELKITTIVVHIYE HHHHCCEEEEEEEEC	18.43	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
73	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHOS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHOS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRS8_HUMAN	PSMC5	physical	10753654

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.