PHLP_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHLP_DROME
• UniProt AC: Q9VUR7
• Protein Name: Phosducin-like protein
• Gene Name: CG7650
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 276
• Protein Description: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers..
• Protein Sequence: MATLEDKLLGEKLEYYCSSSEGEDNGDEGGDNKGASGKSRCSGLTIDTNPDATPAGGFRQQSSTNTGPKGVVKDWQRFKQLEAERRDETERQRLALAKKLTITATTSAEDEERKRQEELDAELDELMSEDFLQQYQKQRMAEMLRQTGHHQQFGQVQQLTSHEEFLACVEQENKHTTIIIHIYERQLAACATLNKCLDSLASDYPSIKFAKICSSVAGMSRDFRTKGLPALLVYKAQAVIGNFVRLTDDLSDDFFASDVESFLIEHGIIVDRALYN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	EKLEYYCSSSEGEDN HHEEEECCCCCCCCC	22.30	22817900
19	Phosphorylation	KLEYYCSSSEGEDNG HEEEECCCCCCCCCC	28.93	22817900
20	Phosphorylation	LEYYCSSSEGEDNGD EEEECCCCCCCCCCC	33.07	22817900
42	Phosphorylation	ASGKSRCSGLTIDTN CCCCCCCCCCEECCC	35.41	17372656

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHLP_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHLP_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHLP_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of PHLP_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, AND MASSSPECTROMETRY.
PubMed: 17372656

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-19 AND SER-20,AND MASS SPECTROMETRY.
PubMed: 18327897