PHLP1_RAT - dbPTM
PHLP1_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PHLP1_RAT
UniProt AC Q9WTR8
Protein Name PH domain leucine-rich repeat protein phosphatase 1
Gene Name Phlpp1
Organism Rattus norvegicus (Rat).
Sequence Length 1696
Subcellular Localization Cytoplasm . Membrane
Peripheral membrane protein .
Isoform 1: Cytoplasm . Cell membrane .
Isoform 2: Nucleus, nucleoplasm . Nucleus membrane . Cytoplasm . Cell membrane .
Protein Description Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA. [PubMed: 20819118 Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons while isoform 1 may promote Akt and PKC activation and inhibit ERK signaling]
Protein Sequence MEPAAAAPAQRLADPTGEDRAPAAAAAAEGGRSPDSVLSAAAPSGGNGGAAREEAPCEAPPGPLPGRAGGTGRRRRRGVPQPAAGGAAPVTAAGGGANSLLLRRGRLKRNLSAAASSSSSPSSASSAAGGLPASCSASASLCTRSLDRKTLLQKHRQLLQLQPSDRDWVRHQLQRGCVHVFDRHMASSYLRPVLCTLDTTAAEVAARLLQLGHKGGGVVKVLGHGPPPAAAPAASDQTPATELGRDVEPPPSSSTVGAVRGPARAPPADLPLPGGAWTRCAPRVNPAPSDSSPGELFAGGPCSPSRAPRPASDTESFSLSPSAESVSDRLDPYSSGGGSSSSSEELEADPATVLTGPSGPPHHPVRSSQPRPPSPKTSALLQPKAPTGVDGTGLVVGEGPGDDKAVAAAAPGVPLWTPGRIRETVQKTSSPPSLYVQLHGETTRRLEADEKPLQIQNDYLFQLGFGELWRVQEEGMDSEIGCLIRFYAGKPHSTGSSERIQLSGMYNVRKGKMQLPVNRWTRRQVILCGTCLIVSSVKDSSSGKMHVLPLIGGKVEEVKKHQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLGELQRFTKLKSLNLSNNHLGAFPSAVCSIPTLAELNVSCNALQEVPAAVGAMQNLQTFLLDGNFLQSLPAELENMHQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMAGNCMETLRLQALRRMPHIKHVDLRLNILRKLITDEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLNICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNCLESVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNRLARLPERLERTSVEVLDVQHNQIIELPPNLLMKADSLRFLNASANKLETLPPATLSEETSSILQELYLTNNSLTDKCVPLLTGHPRLKILHMAYNRLQSFPASKMAKLEELEEIDISGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEVKCVDLSCNELSEITLPENLPPKLQELDLTGNPRLALDHKSLELLNNIRCFKIDQPSAGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFRDNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIRHDPVDLGGSFTLTSANVGKCQTVLCRNGKPLSLSRSYTMSCEEERKRIKQHKAIITEDGKVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSIEEAVEAVRNVPDALAAAKKLCTLAQSYGCHDSISAVVVQLSVTEDSFCCCELSVGGSMPPPSPGIFPPSVSMVIKDRPSDGLGVPSSSSGMASEISSELSTSEMSSEVGSTASDEPPSGALSESSPAYPSEQRCMLHPVCLSNSFQRQLSSATFSSAFSDNGLDSDDEEPIEGVFSNGSRVEVEVDIHCSRAKEKERQQHLLQVPAEASDEGIVISANEDESGLSKKTDISAVGTIGRRRANGSVPPQERSHNVIEVATDAPLRKPGGYFAAPAQPDPDDQFIIPPELEEEVKEIMKHHQEQQQQQQQQQQQQQQQPPPPPQPPQAQAQAQAQAQRPFQMDHLPDCYDTPL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEPAAAAP
-------CCCCCCCC		53.63-
33PhosphorylationAAAEGGRSPDSVLSA
HHHCCCCCCHHHHHH		36.0127097102
36PhosphorylationEGGRSPDSVLSAAAP
CCCCCCHHHHHHCCC		28.4827097102
39PhosphorylationRSPDSVLSAAAPSGG
CCCHHHHHHCCCCCC		17.4427097102
91PhosphorylationAGGAAPVTAAGGGAN
CCCCCCCEECCCCHH		15.1028432305
99PhosphorylationAAGGGANSLLLRRGR
ECCCCHHHHHHHHCH		21.6228432305
112PhosphorylationGRLKRNLSAAASSSS
CHHHHHHHHHHHCCC		21.2927097102
116PhosphorylationRNLSAAASSSSSPSS
HHHHHHHHCCCCCCC		26.4827097102
117PhosphorylationNLSAAASSSSSPSSA
HHHHHHHCCCCCCCH		29.5227097102
118PhosphorylationLSAAASSSSSPSSAS
HHHHHHCCCCCCCHH		32.1327097102
119PhosphorylationSAAASSSSSPSSASS
HHHHHCCCCCCCHHH		48.4927097102
136PhosphorylationGGLPASCSASASLCT
CCCCCCCHHHHHHHC		23.8226022182
138PhosphorylationLPASCSASASLCTRS
CCCCCHHHHHHHCCC		11.3326022182
140PhosphorylationASCSASASLCTRSLD
CCCHHHHHHHCCCCC		22.8326022182
143PhosphorylationSASASLCTRSLDRKT
HHHHHHHCCCCCHHH		28.6926022182
214UbiquitinationRLLQLGHKGGGVVKV
HHHHCCCCCCCEEEE		58.41-
289PhosphorylationPRVNPAPSDSSPGEL
CCCCCCCCCCCCCCC		52.8327097102
291PhosphorylationVNPAPSDSSPGELFA
CCCCCCCCCCCCCCC		42.6527097102
292PhosphorylationNPAPSDSSPGELFAG
CCCCCCCCCCCCCCC		41.7527097102
303PhosphorylationLFAGGPCSPSRAPRP
CCCCCCCCCCCCCCC		29.1027097102
305PhosphorylationAGGPCSPSRAPRPAS
CCCCCCCCCCCCCCC		25.4428432305
312PhosphorylationSRAPRPASDTESFSL
CCCCCCCCCCCCCCC		47.9927097102
314PhosphorylationAPRPASDTESFSLSP
CCCCCCCCCCCCCCC		30.9127097102
316PhosphorylationRPASDTESFSLSPSA
CCCCCCCCCCCCCCC		23.4127097102
318PhosphorylationASDTESFSLSPSAES
CCCCCCCCCCCCCCH		36.9027097102
320PhosphorylationDTESFSLSPSAESVS
CCCCCCCCCCCCHHH		18.6627097102
322PhosphorylationESFSLSPSAESVSDR
CCCCCCCCCCHHHHC		41.0927097102
325PhosphorylationSLSPSAESVSDRLDP
CCCCCCCHHHHCCCC		27.0027097102
327PhosphorylationSPSAESVSDRLDPYS
CCCCCHHHHCCCCCC		26.7127097102
374PhosphorylationSSQPRPPSPKTSALL
CCCCCCCCCCCCCCC		41.5330181290
378PhosphorylationRPPSPKTSALLQPKA
CCCCCCCCCCCCCCC		24.05-
1145PhosphorylationSHGYTEASGVKNKLC
CCCCCCCCCCCCEEE		37.5826022182
1487PhosphorylationMLHPVCLSNSFQRQL
CCCHHHHCHHHHHHH		25.8727097102
1489PhosphorylationHPVCLSNSFQRQLSS
CHHHHCHHHHHHHHH		21.2727097102
1495PhosphorylationNSFQRQLSSATFSSA
HHHHHHHHHCCHHHH		15.0227097102
1496PhosphorylationSFQRQLSSATFSSAF
HHHHHHHHCCHHHHH		39.6627097102
1498PhosphorylationQRQLSSATFSSAFSD
HHHHHHCCHHHHHCC		26.4627097102
1500PhosphorylationQLSSATFSSAFSDNG
HHHHCCHHHHHCCCC		19.1927097102
1501PhosphorylationLSSATFSSAFSDNGL
HHHCCHHHHHCCCCC		29.1927097102
1504PhosphorylationATFSSAFSDNGLDSD
CCHHHHHCCCCCCCC		29.8627097102
1510PhosphorylationFSDNGLDSDDEEPIE
HCCCCCCCCCCCCCC		52.5927097102
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PHLP1_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PHLP1_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PHLP1_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PHLP1_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PHLP1_RAT

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Related Literatures of Post-Translational Modification

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