PHF10_MOUSE - dbPTM
PHF10_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PHF10_MOUSE
UniProt AC Q9D8M7
Protein Name PHD finger protein 10
Gene Name Phf10
Organism Mus musculus (Mouse).
Sequence Length 497
Subcellular Localization Nucleus.
Protein Description Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth..
Protein Sequence MTAAGPGAAPSPGRCDSDPASPGAQSPKDDNEDNSNDGTHPCKRRRMGSGDSSRSCETSSQDLSFSYYPAENLIEYKWPPDETGEYYMLQEQVSEYLGVTSFKRKYPDLERRDLSHKEKLYLRELNVITETQCTLGLTALRSDEVIDLMIKEYPAKHAEYSVILQEKERQRITDHYKEYSQMQQQSTQKVEASKVPEYIKKAAKKAAEFNSNLNRERMEERRAYFDLQTHVIQVPQGKYKVLPTDRTKVSSYPVALIPGQFQEYYKRYSPDELRYLPLNTALYEPPLDPELPALDSDGDSDDGEDGGGDEKRKNKGTSDSSSGNVSEGDSPPDSQEDTFHGRQKSKDKMATPRKDGSKRSVLSKSAPGYKPKVIPNALCGICLKGKESNKKGKAESLIHCSQCDNSGHPSCLDMTMELVSMIKTYPWQCMECKTCIICGQPHHEEEMMFCDVCDRGYHTFCVGLGAIPSGRWICDCCQRAPPTPRKVGRRGKNSKEG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationAGPGAAPSPGRCDSD
CCCCCCCCCCCCCCC		34.9526026062
17PhosphorylationPSPGRCDSDPASPGA
CCCCCCCCCCCCCCC		49.4725168779
21PhosphorylationRCDSDPASPGAQSPK
CCCCCCCCCCCCCCC		29.2921743459
26PhosphorylationPASPGAQSPKDDNED
CCCCCCCCCCCCCCC		33.1221743459
35PhosphorylationKDDNEDNSNDGTHPC
CCCCCCCCCCCCCCC		48.9325521595
39PhosphorylationEDNSNDGTHPCKRRR
CCCCCCCCCCCCCCC		26.0523375375
49PhosphorylationCKRRRMGSGDSSRSC
CCCCCCCCCCCCCCC		30.0425293948
52PhosphorylationRRMGSGDSSRSCETS
CCCCCCCCCCCCCCC		31.0425293948
53PhosphorylationRMGSGDSSRSCETSS
CCCCCCCCCCCCCCC		32.7125293948
55PhosphorylationGSGDSSRSCETSSQD
CCCCCCCCCCCCCCC		20.4623649490
58PhosphorylationDSSRSCETSSQDLSF
CCCCCCCCCCCCCCC		37.7025293948
59PhosphorylationSSRSCETSSQDLSFS
CCCCCCCCCCCCCCE		12.0525293948
60PhosphorylationSRSCETSSQDLSFSY
CCCCCCCCCCCCCEE		34.8225293948
64PhosphorylationETSSQDLSFSYYPAE
CCCCCCCCCEEECCC		22.0425293948
66PhosphorylationSSQDLSFSYYPAENL
CCCCCCCEEECCCHH		22.0025293948
67PhosphorylationSQDLSFSYYPAENLI
CCCCCCEEECCCHHE		16.0925293948
68PhosphorylationQDLSFSYYPAENLIE
CCCCCEEECCCHHEE		8.5125293948
76PhosphorylationPAENLIEYKWPPDET
CCCHHEEEECCCCCC		16.0328576409
239PhosphorylationIQVPQGKYKVLPTDR
EECCCCCCEECCCCC		17.1019144319
266UbiquitinationGQFQEYYKRYSPDEL
CHHHHHHHHCCHHHH		43.91-
268PhosphorylationFQEYYKRYSPDELRY
HHHHHHHCCHHHHCC		22.0225777480
269PhosphorylationQEYYKRYSPDELRYL
HHHHHHCCHHHHCCC		29.8822942356
280PhosphorylationLRYLPLNTALYEPPL
HCCCCCCCCCCCCCC		26.2321183079
283PhosphorylationLPLNTALYEPPLDPE
CCCCCCCCCCCCCCC		24.7523737553
296PhosphorylationPELPALDSDGDSDDG
CCCCCCCCCCCCCCC		44.3221082442
300PhosphorylationALDSDGDSDDGEDGG
CCCCCCCCCCCCCCC		43.0321082442
317PhosphorylationEKRKNKGTSDSSSGN
HHCCCCCCCCCCCCC		30.8525619855
318PhosphorylationKRKNKGTSDSSSGNV
HCCCCCCCCCCCCCC		44.1325619855
320PhosphorylationKNKGTSDSSSGNVSE
CCCCCCCCCCCCCCC		26.6025619855
321PhosphorylationNKGTSDSSSGNVSEG
CCCCCCCCCCCCCCC		47.4525168779
322PhosphorylationKGTSDSSSGNVSEGD
CCCCCCCCCCCCCCC		38.0423375375
326PhosphorylationDSSSGNVSEGDSPPD
CCCCCCCCCCCCCCC		39.6027087446
330PhosphorylationGNVSEGDSPPDSQED
CCCCCCCCCCCCCCC		49.5427087446
334PhosphorylationEGDSPPDSQEDTFHG
CCCCCCCCCCCCCCC		41.0425619855
338PhosphorylationPPDSQEDTFHGRQKS
CCCCCCCCCCCCCCC		19.4425619855
364AcetylationSKRSVLSKSAPGYKP
CCCCCCCCCCCCCCC		46.6123806337
483PhosphorylationCCQRAPPTPRKVGRR
HHHCCCCCCCCCCCC		34.3727149854
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PHF10_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PHF10_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PHF10_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LMX1A_MOUSELmx1aphysical
20211142
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PHF10_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-326, AND MASSSPECTROMETRY.

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