PHB_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHB_RAT
• UniProt AC: P67779
• Protein Name: Prohibitin
• Gene Name: Phb
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 272
• Subcellular Localization: Mitochondrion inner membrane .
• Protein Description: Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging..
• Protein Sequence: MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIYTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAKVFESI ------CCHHHHHHH	18.91	-
4	Acetylation	----MAAKVFESIGK ----CCHHHHHHHHH	37.61	22902405
83	Acetylation	VPVITGSKDLQNVNI CCEEECCCCHHCCCE	64.90	22902405
91	Phosphorylation	DLQNVNITLRILFRP CHHCCCEEEHHHHHH	12.55	30181290
101	O-linked_Glycosylation	ILFRPVASQLPRIYT HHHHHHHHCCCCEEH	32.27	27213235
101	Phosphorylation	ILFRPVASQLPRIYT HHHHHHHHCCCCEEH	32.27	23984901
107	Phosphorylation	ASQLPRIYTSIGEDY HHCCCCEEHHCCCCC	8.84	23991683
108	Phosphorylation	SQLPRIYTSIGEDYD HCCCCEEHHCCCCCC	16.11	23991683
109	Phosphorylation	QLPRIYTSIGEDYDE CCCCEEHHCCCCCCC	16.18	23991683
121	O-linked_Glycosylation	YDERVLPSITTEILK CCCCCCCHHHHHHHH	28.53	27213235
121	Phosphorylation	YDERVLPSITTEILK CCCCCCCHHHHHHHH	28.53	23991683
123	Phosphorylation	ERVLPSITTEILKSV CCCCCHHHHHHHHHH	23.78	23991683
124	Phosphorylation	RVLPSITTEILKSVV CCCCHHHHHHHHHHH	21.25	23991683
128	Succinylation	SITTEILKSVVARFD HHHHHHHHHHHHHCC	47.03	26843850
128	Acetylation	SITTEILKSVVARFD HHHHHHHHHHHHHCC	47.03	22902405
151	Phosphorylation	ELVSRQVSDDLTERA HHHHHHCCCHHHHHH	19.64	23991683
155	Phosphorylation	RQVSDDLTERAATFG HHCCCHHHHHHHHHC	30.35	30181290
186	Acetylation	FTEAVEAKQVAQQEA HHHHHHHHHHHHHHH	31.62	22902405
202	Succinylation	RARFVVEKAEQQKKA HHHHHHHHHHHHHHE	45.68	-
202	Succinylation	RARFVVEKAEQQKKA HHHHHHHHHHHHHHE	45.68	-
202	Acetylation	RARFVVEKAEQQKKA HHHHHHHHHHHHHHE	45.68	25786129
207	Acetylation	VEKAEQQKKAAIISA HHHHHHHHHEEEEEC	44.04	22902405
213	Phosphorylation	QKKAAIISAEGDSKA HHHEEEEECCCCHHH	17.72	30181290
218	Phosphorylation	IISAEGDSKAAELIA EEECCCCHHHHHHHH	34.74	23984901
240	Succinylation	DGLIELRKLEAAEDI CCHHHHHHHHHHHHH	64.40	26843850
249	Phosphorylation	EAAEDIAYQLSRSRN HHHHHHHHHHHCCCC	15.43	23991683
252	Phosphorylation	EDIAYQLSRSRNITY HHHHHHHHCCCCCEE	16.82	23991683
258	Phosphorylation	LSRSRNITYLPAGQS HHCCCCCEEECCCCE	23.66	25575281
259	Phosphorylation	SRSRNITYLPAGQSV HCCCCCEEECCCCEE	13.59	25575281
265	Phosphorylation	TYLPAGQSVLLQLPQ EEECCCCEEEECCCC	17.51	25575281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHB_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHB_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHB_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PHB_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.