| UniProt ID | PGTA_MOUSE | |
|---|---|---|
| UniProt AC | Q9JHK4 | |
| Protein Name | Geranylgeranyl transferase type-2 subunit alpha | |
| Gene Name | Rabggta | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 567 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.. | |
| Protein Sequence | MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKREAGELDESVLELTSQILGANPDFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEADERNFHCWDYRRFVAAQAAVAPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPENVLLRELELVQNAFFTDPNDQSAWFYHRWLLGRAEPHDVLCCLHVSREEACLSVCFSRPLIVGSKMGTLLLTVDEAPLSVEWRTPDGRNRPSHVWLCDLPAASLNDHLPQHTFRVIWTGSDTQKECVLLKGHQECWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLEYFSTLKAVDPMRAAYLDDLRSKFLVENSVLKMEYADVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNVLENLDGVANLPRLRELLLCNNRLQQSAALQTLASCPRLVFLNLQGNSLCQEEGIRERLAEMLPSVSSILT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | HGRLKVKTSEEQAEA CCCCCCCCHHHHHHH | 44.34 | 29899451 | |
| 10 | Phosphorylation | GRLKVKTSEEQAEAK CCCCCCCHHHHHHHH | 33.16 | 30352176 | |
| 38 | Ubiquitination | ATQAVFQKREAGELD HHHHHHHHHHCCCCC | 40.52 | 27667366 | |
| 81 | Phosphorylation | QQLETQKSPEELAAL HHHHHCCCHHHHHHH | 27.94 | 29899451 | |
| 98 | Phosphorylation | AELGFLESCLRVNPK HHHCHHHHHHCCCCC | 22.16 | 10737774 | |
| 99 | S-nitrosocysteine | ELGFLESCLRVNPKS HHCHHHHHHCCCCCH | 1.73 | - | |
| 99 | S-nitrosylation | ELGFLESCLRVNPKS HHCHHHHHHCCCCCH | 1.73 | 21278135 | |
| 99 | S-palmitoylation | ELGFLESCLRVNPKS HHCHHHHHHCCCCCH | 1.73 | 28526873 | |
| 387 | Phosphorylation | ENKWCLLTIILLMRA CCHHHHHHHHHHHHH | 7.94 | 21149613 | |
| 400 | Phosphorylation | RALDPLLYEKETLEY HHHHHHHHCHHHHHH | 32.41 | 21149613 | |
| 402 | Ubiquitination | LDPLLYEKETLEYFS HHHHHHCHHHHHHHH | 42.30 | - | |
| 404 | Phosphorylation | PLLYEKETLEYFSTL HHHHCHHHHHHHHHC | 35.64 | 22871156 | |
| 421 | Phosphorylation | VDPMRAAYLDDLRSK CCHHHHHHHHHHHHH | 15.07 | 22871156 | |
| 434 | Phosphorylation | SKFLVENSVLKMEYA HHHHHHCCCEEEEEC | 18.47 | 21149613 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PGTA_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PGTA_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PGTA_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PGTA_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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