PGS2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PGS2_RAT
• UniProt AC: Q01129
• Protein Name: Decorin
• Gene Name: Dcn
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 354
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix..
• Protein Sequence: MKATLVLFLLAQVSWAGPFEQRGLFDFMLEDEASGIIPYDPDNPLISMCPYRCQCHLRVVQCSDLGLDKVPWEFPPDTTLLDLQNNKITEIKEGAFKNLKDLHTLILVNNKISKISPEAFKPLVKLERLYLSKNHLKELPEKLPKTLQELRLHDNEITKLKKSVFNGLNRMIVIELGGNPLKNSGIENGALQGMKGLGYIRISDTNITAIPQGLPTSISELHLDGNKIAKVDAASLKGMSNLSKLGLSFNSITVVENGSLANVPHLRELHLDNNKLLRVPAGLAQHKYVQVVYLHNNNISEVGQHDFCLPSYQTRKTSYTAVSLYSNPVRYWQIHPHTFRCVFGRSTIQLGNYK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	O-linked_Glycosylation	FMLEDEASGIIPYDP EEECCCCCCCCCCCC	28.60	-
92	Acetylation	NNKITEIKEGAFKNL CCCCCEEHHCCCCCH	43.81	22902405
100	Acetylation	EGAFKNLKDLHTLIL HCCCCCHHHHHEEEE	68.58	22902405
114	Acetylation	LVNNKISKISPEAFK EECCCHHCCCHHHHH	51.15	22902405
121	Acetylation	KISPEAFKPLVKLER CCCHHHHHHHHHHHH	44.48	22902405
125	Acetylation	EAFKPLVKLERLYLS HHHHHHHHHHHHHCC	52.92	22902405
133	Acetylation	LERLYLSKNHLKELP HHHHHCCHHHHHHCH	45.88	22902405
137	Acetylation	YLSKNHLKELPEKLP HCCHHHHHHCHHHCC	50.05	22902405
142	Acetylation	HLKELPEKLPKTLQE HHHHCHHHCCHHHHH	69.05	22902405
159	Acetylation	LHDNEITKLKKSVFN CCHHHHHHHHHHHHC	65.06	22902405
163	Phosphorylation	EITKLKKSVFNGLNR HHHHHHHHHHCCCCC	30.29	22673903
206	N-linked_Glycosylation	YIRISDTNITAIPQG EEEECCCCEEEECCC	34.30	-
230	Acetylation	LDGNKIAKVDAASLK ECCCEEEEECHHHHC	44.09	22902405
237	Acetylation	KVDAASLKGMSNLSK EECHHHHCCCCCHHH	50.50	22902405
241	N-linked_Glycosylation	ASLKGMSNLSKLGLS HHHCCCCCHHHCCCC	39.17	-
257	N-linked_Glycosylation	NSITVVENGSLANVP CEEEEEECCCCCCCC	33.47	-
275	Acetylation	ELHLDNNKLLRVPAG EEECCCCCEECCCCH	55.97	22902405
298	N-linked_Glycosylation	VVYLHNNNISEVGQH EEEEECCCCCCCCCC	44.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PGS2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PGS2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PGS2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_RAT	Ubc	physical	20665669
OTUB1_RAT	Otub1	physical	22279542
UBC_RAT	Ubc	physical	22279542

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.