| UniProt ID | PGPS1_HUMAN | |
|---|---|---|
| UniProt AC | Q32NB8 | |
| Protein Name | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial | |
| Gene Name | PGS1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 556 | |
| Subcellular Localization | Mitochondrion. | |
| Protein Description | Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.. | |
| Protein Sequence | MAVAAAAAAGPVFWRRLLGLLPGRPGLAALLGRLSDRLGRNRDRQRRRSPWLLLAPLLSPAVPQVTSPPCCLCPEGVHRFQWIRNLVPEFGVSSSHVRVLSSPAEFFELMKGQIRVAKRRVVMASLYLGTGPLEQELVDCLESTLEKSLQAKFPSNLKVSILLDFTRGSRGRKNSRTMLLPLLRRFPEQVRVSLFHTPHLRGLLRLLIPERFNETIGLQHIKVYLFDNSVILSGANLSDSYFTNRQDRYVFLQDCAEIADFFTELVDAVGDVSLQLQGDDTVQVVDGMVHPYKGDRAEYCKAANKRVMDVINSARTRQQMLHAQTFHSNSLLTQEDAAAAGDRRPAPDTWIYPLIQMKPFEIQIDEIVTETLLTEAERGAKVYLTTGYFNLTQAYMDLVLGTRAEYQILLASPEVNGFFGAKGVAGAIPAAYVHIERQFFSEVCSLGQQERVQLQEYWRRGWTFHAKGLWLYLAGSSLPCLTLIGSPNFGYRSVHRDLEAQIAIVTENQALQQQLHQEQEQLYLRSGVVSSATFEQPSRQVKLWVKMVTPLIKNFF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 49 | Phosphorylation | RDRQRRRSPWLLLAP HHHHHHHCCHHHHHH | 20.72 | 24719451 | |
| 126 (in isoform 2) | Ubiquitination | - | 2.73 | 21890473 | |
| 148 | Phosphorylation | LESTLEKSLQAKFPS HHHHHHHHHHCCCCC | 19.15 | - | |
| 152 | Ubiquitination | LEKSLQAKFPSNLKV HHHHHHCCCCCCCEE | 44.86 | 21890473 | |
| 152 (in isoform 1) | Ubiquitination | - | 44.86 | 21890473 | |
| 152 (in isoform 3) | Ubiquitination | - | 44.86 | 21890473 | |
| 155 | Phosphorylation | SLQAKFPSNLKVSIL HHHCCCCCCCEEEEE | 58.91 | - | |
| 177 | Phosphorylation | RGRKNSRTMLLPLLR CCCCCCHHCHHHHHH | 16.40 | 24043423 | |
| 224 | Phosphorylation | GLQHIKVYLFDNSVI CCCCEEEEEECCCEE | 9.17 | 19702290 | |
| 241 | Phosphorylation | GANLSDSYFTNRQDR CCCCCCCCCCCCCCC | 21.29 | 19702290 | |
| 325 | Phosphorylation | QQMLHAQTFHSNSLL HHHHHHHCCCCCCCC | 24.89 | 28857561 | |
| 328 | Phosphorylation | LHAQTFHSNSLLTQE HHHHCCCCCCCCCHH | 24.75 | 28857561 | |
| 330 | Phosphorylation | AQTFHSNSLLTQEDA HHCCCCCCCCCHHHH | 27.98 | 28857561 | |
| 549 | Phosphorylation | KLWVKMVTPLIKNFF HHHHHHHHHHHHHCC | 14.63 | 24719451 | |
| 553 | Ubiquitination | KMVTPLIKNFF---- HHHHHHHHHCC---- | 56.22 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PGPS1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PGPS1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PGPS1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PGPS1_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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