dbPTM

PGPLA_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PGPLA_DROME
UniProt AC	Q95T64
Protein Name	Peptidoglycan-recognition protein LA
Gene Name	PGRP-LA
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	368
Subcellular Localization	Cell membrane Single-pass membrane protein .
Protein Description	Peptidoglycan-recognition protein probably involved in innate immnunity by binding to peptidoglycans (PGN) of bacteria and activating the immune response..
Protein Sequence	MFEENNSPTTDNSLWTLQGRQRASPAQRLHNLTSAGSSTSSSGLPLPQNIFTNPAIQPSSVINLNHSTDVVIGPMTQYQGPVSIYYMDYMEAHAMQTAAGINSNNANGNGNANRSRDKSPSRRVTRNTILLITLILLVLATGLIVLYVELNRPKPELPSNKAIYFGNNYDHQTFPNLGNGHLVVDREQWGASKNSHGLTIPLKRPIPYVLITHIGVQSLPCDNIYKCSIKMRTIQDSAIAEKGLPDIQSNFYVSEEGNIYVGRGWDWANTYANQTLAITFMGDYGRFKPGPKQLEGVQFLLAHAVANRNIDVDYKLVAQNQTKVTRSPGAYVYQEIRNWPHFYGCGMDEAPACGIELGMKTESWDAKQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
273	N-linked_Glycosylation	DWANTYANQTLAITF HHHHCCCCCEEEEEE	25.59	-
320	N-linked_Glycosylation	DYKLVAQNQTKVTRS CCEEEECCCCEEECC	41.57	17893096

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PGPLA_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PGPLA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PGPLA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PGPLA_DROME !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PGPLA_DROME

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Identification of N-glycosylated proteins from the central nervoussystem of Drosophila melanogaster."; Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L.,Panin V.; Glycobiology 17:1388-1403(2007). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-320, AND MASSSPECTROMETRY.	17893096 [Abstract]