PGGHG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PGGHG_HUMAN
• UniProt AC: Q32M88
• Protein Name: Protein-glucosylgalactosylhydroxylysine glucosidase {ECO:0000303|PubMed:26682924}
• Gene Name: PGGHG {ECO:0000303|PubMed:26682924, ECO:0000312|HGNC:HGNC:26210}
• Organism: Homo sapiens (Human).
• Sequence Length: 737
• Protein Description: Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins..
• Protein Sequence: MEDAGEDPTTFAAHSLPSDPRLLATVTNAYLGTRVFHDTLHVSGVYNGAGGDTHRAMLPSPLNVRLEAPAGMGEQLTETFALDTNTGSFLHTLEGPRFRASQCIYAHRTLPHVLAFRVSIARLAPGSGPITLLLRSAFSPESPDLDLHQGPDFQGARYLYGHTLTPEQPGGPQQEVHMLWTPAPPDLTLGEGEEARTWDFLTAVGGSQAEAQACLTEALQLQARGALYTAHAQAWAQLWVECGLDVVGPLQLRQALRGSLYYLLSALPQPKAPGYICHGLSPGGLSNGSREECYWGHVFWDQDLWMFPSILMFHPEAARAILEYRIRTLDGALENAQNLGYQGAKFAWESADSGLEVCPEDIYGVQEVHVNGAVVLAFELYYHTTQDLQLFREAGGWDVVRAVAEFWCSRVEWSPREEKYHLRGVMSPDEYHSGVNNSVYTNVLVQNSLRFAAALAQDLGLPIPSQWLAVADKIKVPFDVEQNFHPEFDGYEPGEVVKQADVVLLGYPVPFSLSPDVRRKNLEIYEAVTSPQGPAMTWSMFAVGWMELKDAVRARGLLDRSFANMAEPFKVWTENADGSGAVNFLTGMGGFLQAVVFGCTGFRVTRAGVTFDPVCLSGISRVSVSGIFYQGNKLNFSFSEDSVTVEVTARAGPWAPHLEAELWPSQSRLSLLPGHKVSFPRSAGRIQMSPPKLPGSSSSEFPGRTFSDVRDPLQSPLWVTLGSSSPTESLTVDPASE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	SDPRLLATVTNAYLG CCHHHHHHHHHHHCC		29083192
27	Phosphorylation	PRLLATVTNAYLGTR HHHHHHHHHHHCCCC		29083192
30	Phosphorylation	LATVTNAYLGTRVFH HHHHHHHHCCCCEEC		29083192
33	Phosphorylation	VTNAYLGTRVFHDTL HHHHHCCCCEECCEE		29083192
414	Phosphorylation	WCSRVEWSPREEKYH HHHCCCCCCCHHHHC		24719451
448	Phosphorylation	TNVLVQNSLRFAAAL HHHHHHHHHHHHHHH		24719451
475	Ubiquitination	LAVADKIKVPFDVEQ HHHHCCCCCCCCCCC		-
512	Phosphorylation	LGYPVPFSLSPDVRR ECCCCCCCCCHHHHH		22199227
514	Phosphorylation	YPVPFSLSPDVRRKN CCCCCCCCHHHHHHC		22199227
689	Phosphorylation	SAGRIQMSPPKLPGS CCCCEEECCCCCCCC		27080861
696	Phosphorylation	SPPKLPGSSSSEFPG CCCCCCCCCCCCCCC		27080861
697	Phosphorylation	PPKLPGSSSSEFPGR CCCCCCCCCCCCCCC		23312004
698	Phosphorylation	PKLPGSSSSEFPGRT CCCCCCCCCCCCCCC		27080861
699	Phosphorylation	KLPGSSSSEFPGRTF CCCCCCCCCCCCCCH		29802988
723	Phosphorylation	PLWVTLGSSSPTESL CEEEEECCCCCCCCC		28348404
724	Phosphorylation	LWVTLGSSSPTESLT EEEEECCCCCCCCCE		27690223
725	Phosphorylation	WVTLGSSSPTESLTV EEEECCCCCCCCCEE		27690223
727	Phosphorylation	TLGSSSPTESLTVDP EECCCCCCCCCEECC		27690223
729	Phosphorylation	GSSSPTESLTVDPAS CCCCCCCCCEECCCC		24719451
731	Phosphorylation	SSPTESLTVDPASE- CCCCCCCEECCCCC-		28348404
736	Phosphorylation	SLTVDPASE------ CCEECCCCC------		28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PGGHG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PGGHG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PGGHG_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PGGHG_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.