PGES2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PGES2_MOUSE
• UniProt AC: Q8BWM0
• Protein Name: Prostaglandin E synthase 2
• Gene Name: Ptges2
• Organism: Mus musculus (Mouse).
• Sequence Length: 384
• Subcellular Localization: Golgi apparatus membrane ; Single-pass membrane protein . Nucleus . According to PubMed:12050152, some fraction may be nuclear.; Prostaglandin E synthase 2 truncated form: Cytoplasm . Synthesized as a Golgi membrane-bound protein, which is furth
• Protein Description: Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (By similarity). May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear..
• Protein Sequence: MAQAARLSWVLVSSRCALTEGLLTRPWQPLSAQSRAGFTRVAAGSRGAAVRKGSPRLLGAAALALGGALGLYHTVRWHQRSQDLRAERSAAQLPLSNSLQLTLYQYKTCPFCSKVRAFLDFHSLPYQVVEVNPVRRTEIKFSSYRKVPILVAQEGDSLQQLNDSSVIISALKTYLVSGQPLEEVITYYPPMKAMNDQGKEVTEFCNKYWLMLDEKEAQQMYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPAEALASFDYIVREGKFGAVEAAMAKYVGAAAMYLISKRLKSRHHLQDDVRVDLYEAANKWVTAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLEAFDDLMRHSHIQPWYLRMERAIEEAPSVHHVNPSCKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	RLSWVLVSSRCALTE HHHHHHHHCCCCCCC	14.12	28059163
31	Phosphorylation	TRPWQPLSAQSRAGF CCCCCCCCHHHCCCC	30.83	-
34	Phosphorylation	WQPLSAQSRAGFTRV CCCCCHHHCCCCCCH	24.66	-
72	Phosphorylation	LGGALGLYHTVRWHQ HHHHHHHHHHHHHHH	8.14	24759943
74	Phosphorylation	GALGLYHTVRWHQRS HHHHHHHHHHHHHHC	9.75	24759943
102	Phosphorylation	LSNSLQLTLYQYKTC CCCCEEEEEEEECCC	15.51	28059163
104	Phosphorylation	NSLQLTLYQYKTCPF CCEEEEEEEECCCCC	12.45	20116462
106	Phosphorylation	LQLTLYQYKTCPFCS EEEEEEEECCCCCHH	8.49	20116462
140	Ubiquitination	PVRRTEIKFSSYRKV CCCCCEEECCCCCCC	32.72	22790023
224	Acetylation	AQQMYGGKEARTEEM HHHHHCCCCCCCHHH	43.78	23954790
232	Acetylation	EARTEEMKWRQWADD CCCCHHHHHHHHHHH	42.37	23201123
286	Phosphorylation	YVGAAAMYLISKRLK HHHHHHHHHHHHHHH	8.99	25293948
289	Phosphorylation	AAAMYLISKRLKSRH HHHHHHHHHHHHHCC	14.77	25293948
312	Acetylation	DLYEAANKWVTAVGK HHHHHHHHHHHHCCC	38.01	23954790
374	Phosphorylation	RAIEEAPSVHHVNPS HHHHHCCCCCCCCCC	40.92	23684622
381	Phosphorylation	SVHHVNPSCKD---- CCCCCCCCCCC----	28.70	23684622
382	S-nitrosylation	VHHVNPSCKD----- CCCCCCCCCC-----	6.40	21278135
382	S-nitrosocysteine	VHHVNPSCKD----- CCCCCCCCCC-----	6.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PGES2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PGES2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PGES2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CEBPB_MOUSE	Cebpb	physical	15879117

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.