PGAM5_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PGAM5_RAT
• UniProt AC: Q562B5
• Protein Name: Serine/threonine-protein phosphatase PGAM5, mitochondrial
• Gene Name: Pgam5
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 288
• Subcellular Localization: Mitochondrion outer membrane; Single-pass membrane protein.
• Protein Description: Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression (By similarity). Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore..
• Protein Sequence: MAFRQALQLAACGLAGGSAAVLFSAVAVGKPRAGGDADTRTTEPLAWTGARPGHGVWDSNWDRREPLSLINLKKRNVEFGEDELASRLDHYKAKATRHIFLIRHSQYNVDGSMEKDRTLTPLGREQAELTGIRLASLGLKFNKIVHSSMTRAVETTDIISKHLPGVCRVSTDLLREGAPIEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIHRADAKQEEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGDTGFMPPDKITRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	RAGGDADTRTTEPLA CCCCCCCCCCCCCCC	31.47	23984901
41	Phosphorylation	GGDADTRTTEPLAWT CCCCCCCCCCCCCCC	37.29	23984901
42	Phosphorylation	GDADTRTTEPLAWTG CCCCCCCCCCCCCCC	32.11	23984901
86	Phosphorylation	FGEDELASRLDHYKA CCHHHHHHHHHHHHH	46.10	-
92	Acetylation	ASRLDHYKAKATRHI HHHHHHHHHHCCEEE	39.74	22902405
112	Phosphorylation	SQYNVDGSMEKDRTL CEECCCCCCCCCCCC	21.21	23984901
115	Acetylation	NVDGSMEKDRTLTPL CCCCCCCCCCCCCCC	43.82	-
143	Acetylation	SLGLKFNKIVHSSMT HHCCCHHHHHHHHHC	49.60	22902405
190	Acetylation	DPPVSHWKPEAVQYY CCCCCCCCHHHHHHH	27.79	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Keap1	P57790	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PGAM5_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PGAM5_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PGAM5_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.