PFKAP_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PFKAP_RAT
• UniProt AC: P47860
• Protein Name: ATP-dependent 6-phosphofructokinase, platelet type {ECO:0000255|HAMAP-Rule:MF_03184}
• Gene Name: Pfkp
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 788
• Subcellular Localization: Cytoplasm .
• Protein Description: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis..
• Protein Sequence: MSDQDSSTSSTSFPKYLEHLSGDGKAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGMVDGGSNIVEAKWECVSSILQVGGTIIGSARCQAFRSREGRLKAACNLVRLGITNLCVIGGDGSLTGANLFRKEWSGLLEELAKNGEIDSDTVKKHAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEEMCLKLSENRARKKRLNIIIVSEGAIDTQNKPITSEKIKELVVTNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVLALLEATPETPACVVSLRGNQAVRLPLMECVQMTQDVQKAMDERRFDEAVKLRGRSFEGNLNTYKRLAIKEPDDKIPKSNCNVAIINVGAPAAGMNAAVRSAVRVGIAEGHKMFAIYDGFDGLANGQIKEIGWGDVGGWTGQGGSILGTKRTLPGKYLEKIAEQMHSKNINALLIIGGFEAYLGLLELAAARNKHEAFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEQFDIRDLQSNVMHLTEKMKTSIQRGLVLRNENCSVNYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISAKLKGSHGTGKKFVSDDSICVLGIQKRDLLFKPVAELRKATDFEHRIPKQQWWLKLRPIMKILAKYEASYDMSDVGKLEPVHNHGELSAI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MSDQDSST -------CCCCCCCC		-
2	Phosphorylation	------MSDQDSSTS ------CCCCCCCCC		27097102
6	Phosphorylation	--MSDQDSSTSSTSF --CCCCCCCCCCCCH		-
12	Phosphorylation	DSSTSSTSFPKYLEH CCCCCCCCHHHHHHH		-
15	Ubiquitination	TSSTSFPKYLEHLSG CCCCCHHHHHHHHCC		-
21	Phosphorylation	PKYLEHLSGDGKAIG HHHHHHHCCCCCEEE		-
81	S-nitrosocysteine	IVEAKWECVSSILQV EEHHHHHHHHHHHHC		-
139	Acetylation	TGANLFRKEWSGLLE CHHHHHHHHHHHHHH		22902405
142	Phosphorylation	NLFRKEWSGLLEELA HHHHHHHHHHHHHHH		22673903
281	Ubiquitination	GAIDTQNKPITSEKI CCCCCCCCCCCHHHH		-
287	Ubiquitination	NKPITSEKIKELVVT CCCCCHHHHHHHHEE		-
313	Phosphorylation	GHVQRGGTPSAFDRI EEHHHCCCCCHHHHH		22673903
315	Phosphorylation	VQRGGTPSAFDRILA HHHCCCCCHHHHHHH		22673903
381	Acetylation	RRFDEAVKLRGRSFE CCHHHHHHHCCCCCC		22902405
386	Phosphorylation	AVKLRGRSFEGNLNT HHHHCCCCCCCCCCH		27097102
395	Acetylation	EGNLNTYKRLAIKEP CCCCCHHHEEEECCC		-
395	Ubiquitination	EGNLNTYKRLAIKEP CCCCCHHHEEEECCC		-
480	Acetylation	GGSILGTKRTLPGKY CCCCCCCCCCCCHHH		22902405
486	Acetylation	TKRTLPGKYLEKIAE CCCCCCHHHHHHHHH		22902405
490	Acetylation	LPGKYLEKIAEQMHS CCHHHHHHHHHHHHC		22902405
540	O-linked_Glycosylation	VMVPATVSNNVPGSD EEEECEECCCCCCCC		-
651	Phosphorylation	NYTTDFIYQLYSEEG EEEHHHHHHHHCCCC		-
666	Acetylation	KGVFDCRKNVLGHMQ CCCEECCHHHHHHCC		22902405
688	Acetylation	FDRNFGTKISAKAME CCCCCCCCCHHHHHH		22902405
688	Ubiquitination	FDRNFGTKISAKAME CCCCCCCCCHHHHHH		-
692	Ubiquitination	FGTKISAKAMEWISA CCCCCHHHHHHHHHH		-
730	Acetylation	QKRDLLFKPVAELRK CCCCCCCCCHHHHHH		22902405
747	Acetylation	DFEHRIPKQQWWLKL CCCCCCCHHHHHHHH		22902405
753	Acetylation	PKQQWWLKLRPIMKI CHHHHHHHHHHHHHH		22902405
759	Ubiquitination	LKLRPIMKILAKYEA HHHHHHHHHHHHHHC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PFKAP_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PFKAP_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PFKAP_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PFKAP_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.