UniProt ID | PFKAM_RAT | |
---|---|---|
UniProt AC | P47858 | |
Protein Name | ATP-dependent 6-phosphofructokinase, muscle type {ECO:0000255|HAMAP-Rule:MF_03184} | |
Gene Name | Pfkm | |
Organism | Rattus norvegicus (Rat). | |
Sequence Length | 780 | |
Subcellular Localization | Cytoplasm . | |
Protein Description | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.. | |
Protein Sequence | MTHEEHHEAKTLGIGKAIAVLTSGGDAQGMNATVRAVVRVGIFTGLRVFFVHEGYQGLVDGGEHIREATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLNDLQKDGKITAEERTKSSYLNIVFLVGSIDNDFCGTDMTIGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNTAVRLPLMECVQVTKDVTKAMDEKRFDEAIKLRGRSFMNNWEVYKLLAHVRPPVSKGGLHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKNLEQISANITKYNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQVNVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGNPTPFDRNFATKMGAKATNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVTELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHISRKRSGEAAV | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Acetylation | ------MTHEEHHEA ------CCHHHHHHH | - | ||
10 | Acetylation | HEEHHEAKTLGIGKA HHHHHHHHHCCCCCE | 22902405 | ||
107 | Acetylation | RAAHNLVKRGITNLC HHHHHHHHCCCCEEE | 22902405 | ||
133 | Phosphorylation | DTFRSEWSDLLNDLQ HHHHHHHHHHHHHHH | 22673903 | ||
141 | Acetylation | DLLNDLQKDGKITAE HHHHHHHHCCCCCHH | 22902405 | ||
285 | Acetylation | DIKNLVVKRLGYDTR HHHHHHHHHCCCCCE | 22902405 | ||
304 | Phosphorylation | GHVQRGGTPSAFDRI EEHHHCCCHHHHHHH | 25403869 | ||
306 | Phosphorylation | VQRGGTPSAFDRILG HHHCCCHHHHHHHHH | 22673903 | ||
360 | Acetylation | QVTKDVTKAMDEKRF HHCHHHHHHHHHHHH | 22902405 | ||
372 | Acetylation | KRFDEAIKLRGRSFM HHHHHHHHHHCCHHH | 22902405 | ||
377 | Phosphorylation | AIKLRGRSFMNNWEV HHHHHCCHHHCCHHH | 22673903 | ||
386 | Acetylation | MNNWEVYKLLAHVRP HCCHHHHHHHHCCCC | 22902405 | ||
530 | O-linked_Glycosylation | VVIPATVSNNVPGSD EEEEEECCCCCCCCC | - | ||
557 | Other | CTTCDRIKQSAAGTK HHHHHHHHHCCCCCC | - | ||
615 | Acetylation | NVEHLVQKMKTTVKR CHHHHHHHHHHHHHH | 22902405 | ||
656 | Acetylation | KGIFDSRKNVLGHMQ CCCCCCCCHHHHCHH | 22902405 | ||
678 | Acetylation | FDRNFATKMGAKATN CCHHHHHHHCCHHHH | 22902405 | ||
692 | Acetylation | NWMSGKIKESYRNGR HCCCCCHHHHHHCCC | 22902405 | ||
727 | Acetylation | FQPVTELKDQTDFEH EEEECCCCCCCCCCC | 22902405 | ||
738 | Acetylation | DFEHRIPKEQWWLKL CCCCCCCHHHHHHHH | 22902405 | ||
744 | Acetylation | PKEQWWLKLRPILKI CHHHHHHHHHHHHHH | 22902405 | ||
754 | Acetylation | PILKILAKYEIDLDT HHHHHHHHCCCCCCC | 22902405 | ||
775 | Phosphorylation | EHISRKRSGEAAV-- HHHHHCCCCCCCC-- | 25403869 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PFKAM_RAT !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PFKAM_RAT !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PFKAM_RAT !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of PFKAM_RAT !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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