dbPTM

PFKAM_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PFKAM_RAT
UniProt AC	P47858
Protein Name	ATP-dependent 6-phosphofructokinase, muscle type {ECO:0000255\|HAMAP-Rule:MF_03184}
Gene Name	Pfkm
Organism	Rattus norvegicus (Rat).
Sequence Length	780
Subcellular Localization	Cytoplasm .
Protein Description	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis..
Protein Sequence	MTHEEHHEAKTLGIGKAIAVLTSGGDAQGMNATVRAVVRVGIFTGLRVFFVHEGYQGLVDGGEHIREATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLNDLQKDGKITAEERTKSSYLNIVFLVGSIDNDFCGTDMTIGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNTAVRLPLMECVQVTKDVTKAMDEKRFDEAIKLRGRSFMNNWEVYKLLAHVRPPVSKGGLHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKNLEQISANITKYNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQVNVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGNPTPFDRNFATKMGAKATNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVTELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHISRKRSGEAAV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
2	Acetylation	------MTHEEHHEA ------CCHHHHHHH	-
10	Acetylation	HEEHHEAKTLGIGKA HHHHHHHHHCCCCCE	22902405
107	Acetylation	RAAHNLVKRGITNLC HHHHHHHHCCCCEEE	22902405
133	Phosphorylation	DTFRSEWSDLLNDLQ HHHHHHHHHHHHHHH	22673903
141	Acetylation	DLLNDLQKDGKITAE HHHHHHHHCCCCCHH	22902405
285	Acetylation	DIKNLVVKRLGYDTR HHHHHHHHHCCCCCE	22902405
304	Phosphorylation	GHVQRGGTPSAFDRI EEHHHCCCHHHHHHH	25403869
306	Phosphorylation	VQRGGTPSAFDRILG HHHCCCHHHHHHHHH	22673903
360	Acetylation	QVTKDVTKAMDEKRF HHCHHHHHHHHHHHH	22902405
372	Acetylation	KRFDEAIKLRGRSFM HHHHHHHHHHCCHHH	22902405
377	Phosphorylation	AIKLRGRSFMNNWEV HHHHHCCHHHCCHHH	22673903
386	Acetylation	MNNWEVYKLLAHVRP HCCHHHHHHHHCCCC	22902405
530	O-linked_Glycosylation	VVIPATVSNNVPGSD EEEEEECCCCCCCCC	-
557	Other	CTTCDRIKQSAAGTK HHHHHHHHHCCCCCC	-
615	Acetylation	NVEHLVQKMKTTVKR CHHHHHHHHHHHHHH	22902405
656	Acetylation	KGIFDSRKNVLGHMQ CCCCCCCCHHHHCHH	22902405
678	Acetylation	FDRNFATKMGAKATN CCHHHHHHHCCHHHH	22902405
692	Acetylation	NWMSGKIKESYRNGR HCCCCCHHHHHHCCC	22902405
727	Acetylation	FQPVTELKDQTDFEH EEEECCCCCCCCCCC	22902405
738	Acetylation	DFEHRIPKEQWWLKL CCCCCCCHHHHHHHH	22902405
744	Acetylation	PKEQWWLKLRPILKI CHHHHHHHHHHHHHH	22902405
754	Acetylation	PILKILAKYEIDLDT HHHHHHHHCCCCCCC	22902405
775	Phosphorylation	EHISRKRSGEAAV-- HHHHHCCCCCCCC--	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PFKAM_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PFKAM_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PFKAM_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PFKAM_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PFKAM_RAT

Related Literatures of Post-Translational Modification