PF21A_MOUSE - dbPTM
PF21A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PF21A_MOUSE
UniProt AC Q6ZPK0
Protein Name PHD finger protein 21A
Gene Name Phf21a
Organism Mus musculus (Mouse).
Sequence Length 659
Subcellular Localization Nucleus .
Protein Description Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation (By similarity)..
Protein Sequence MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLSQSENKLQTAQQQPLQPLQQQQPQQPQQQQQQQQQHAQQSAAAPPSLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGPGAEAVQIVAKNTVTLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQLNPTQKQRKNKQGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPPSSHPDSPENEKTETTFTFPAPVQPVSLPSPTSTDGDIHEDFCSVCRKSGQLLMCDTCSRVYHLDCLEPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGTLAIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKELSSSISKCMEMKSSILARQKEMRSSLDKVKRLIRLVHGVDLCRPVDSEATAGALSNGPDCTPPANAASTPAPSPSSQSCTANCNQGEETK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
132O-linked_GlycosylationTASQKTVTTASMITT
CCCCCCCCCCHHHHC		23.1355413077
133O-linked_GlycosylationASQKTVTTASMITTK
CCCCCCCCCHHHHCC		16.6455413085
163PhosphorylationSVVGQRPTIAMVTAI
HHHCCCCEEEEEEEC		24.4530635358
168PhosphorylationRPTIAMVTAINSQKA
CCEEEEEEECCCCCE		14.5630635358
172PhosphorylationAMVTAINSQKAVLST
EEEEECCCCCEEEEC		27.2630635358
178PhosphorylationNSQKAVLSTDVQNTP
CCCCEEEECCCCCCC		18.9030635358
179PhosphorylationSQKAVLSTDVQNTPV
CCCEEEECCCCCCCC		35.7130635358
184PhosphorylationLSTDVQNTPVNLQTS
EECCCCCCCCCEECC		16.1230635358
190PhosphorylationNTPVNLQTSSKVTGP
CCCCCEECCCCCCCC		37.8330635358
191PhosphorylationTPVNLQTSSKVTGPG
CCCCEECCCCCCCCC		18.3930635358
192PhosphorylationPVNLQTSSKVTGPGA
CCCEECCCCCCCCCH		34.2430635358
272 (in isoform 4)Phosphorylation-10.2524759943
273 (in isoform 2)Phosphorylation-5.5224759943
274 (in isoform 4)Phosphorylation-4.3325266776
275 (in isoform 2)Phosphorylation-4.8525266776
286O-linked_GlycosylationTPTTLPTSQNSIHPV
CCCCCCCCCCCCCCE		25.9826192747
333PhosphorylationGPQTVQLSKPSLEKQ
CCCEEECCCCHHHHH		25.9819854140
357PhosphorylationNKQGLVTHDHLEEIQ
CCCCCCCHHHHHHHH		17.0224759943
359PhosphorylationQGLVTHDHLEEIQSK
CCCCCHHHHHHHHHH		27.7725266776
414PhosphorylationKRGRPPKYNAVLGFG
CCCCCCCCCEEEEEC		17.7127717184
424PhosphorylationVLGFGALTPTSPPSS
EEEECCCCCCCCCCC		24.8026643407
426PhosphorylationGFGALTPTSPPSSHP
EECCCCCCCCCCCCC		48.9426643407
427PhosphorylationFGALTPTSPPSSHPD
ECCCCCCCCCCCCCC		35.7027087446
430PhosphorylationLTPTSPPSSHPDSPE
CCCCCCCCCCCCCCC		44.6727087446
431PhosphorylationTPTSPPSSHPDSPEN
CCCCCCCCCCCCCCC		44.8327087446
435PhosphorylationPPSSHPDSPENEKTE
CCCCCCCCCCCCCCC		38.2730352176
443PhosphorylationPENEKTETTFTFPAP
CCCCCCCEEEEECCC		32.2323649490
453PhosphorylationTFPAPVQPVSLPSPT
EECCCCCCCCCCCCC		20.21-
456PhosphorylationAPVQPVSLPSPTSTD
CCCCCCCCCCCCCCC		5.05-
458PhosphorylationVQPVSLPSPTSTDGD
CCCCCCCCCCCCCCC		46.2123984901
460PhosphorylationPVSLPSPTSTDGDIH
CCCCCCCCCCCCCCC		48.9023984901
461PhosphorylationVSLPSPTSTDGDIHE
CCCCCCCCCCCCCCH		28.0823984901
462PhosphorylationSLPSPTSTDGDIHED
CCCCCCCCCCCCCHH		46.6223984901
472PhosphorylationDIHEDFCSVCRKSGQ
CCCHHHHHHHHHCCC		25.0123984901
546AcetylationKAAKEEEKQKLLKWS
HHHCHHHHHHHHHHC		56.8915624257
548AcetylationAKEEEKQKLLKWSSD
HCHHHHHHHHHHCHH		67.8415624267
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PF21A_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PF21A_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PF21A_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PF21A_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PF21A_MOUSE

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Related Literatures of Post-Translational Modification

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