PEX5_MOUSE - dbPTM
PEX5_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PEX5_MOUSE
UniProt AC O09012
Protein Name Peroxisomal targeting signal 1 receptor
Gene Name Pex5
Organism Mus musculus (Mouse).
Sequence Length 639
Subcellular Localization Cytoplasm. Peroxisome membrane
Peripheral membrane protein. Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor (PEX13).
Protein Description Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import..
Protein Sequence MAMRELVEGECGGANPLMKLATHFTQDKALRQEGLRPGPWPPGASAAETVSKPLGVGTEDELVSEFLQDQNATLVSRAPQTFKMDDLLAEMQEIEQSNFRQAPQRAPGVADLALSENWAQEFLAAGDAVDVAQDYNETDWSQEFIAEVTDPLSVSPARWAEEYLEQSEEKLWLGDQEGSSTADRWYDEYHPEEDLQHTASDFVSKVDDPKLANSEFLKFVRQIGEGQVSLESAAGSGGAQAEQWAAEFIQQQGTSEAWVDQFTRPGNKIAALQVEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPWLSDYDDLTSASYDKGYQFEEENPLRDHPQPFEEGLHRLEEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNRTALMALAVSFTNESLQRQACETLRDWLRYSPAYAHLVAPGEEGATGAGPSKRILGSLLSDSLFLEVKDLFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLMWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGGAMSENIWSTLRLALSMLGQSDAYGAADARDLSALLAMFGLPQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
28UbiquitinationATHFTQDKALRQEGL
HHHHHHHHHHHHCCC		39.2322790023
73PhosphorylationFLQDQNATLVSRAPQ
HHHHCCCCCCCCCCC		34.9330352176
115PhosphorylationGVADLALSENWAQEF
CHHHHHCCCCHHHHH		24.23-
153PhosphorylationAEVTDPLSVSPARWA
HHCCCCCCCCHHHHH		26.41-
155PhosphorylationVTDPLSVSPARWAEE
CCCCCCCCHHHHHHH		14.9625338131
163PhosphorylationPARWAEEYLEQSEEK
HHHHHHHHHHHCCCC		13.6725159016
167PhosphorylationAEEYLEQSEEKLWLG
HHHHHHHCCCCCCCC		38.0425159016
170UbiquitinationYLEQSEEKLWLGDQE
HHHHCCCCCCCCCCC		40.6922790023
179PhosphorylationWLGDQEGSSTADRWY
CCCCCCCCCCHHHHH		24.6225521595
180PhosphorylationLGDQEGSSTADRWYD
CCCCCCCCCHHHHHH		38.1728066266
181PhosphorylationGDQEGSSTADRWYDE
CCCCCCCCHHHHHHH		33.9828066266
205UbiquitinationTASDFVSKVDDPKLA
CHHHHHHHCCCHHHC		44.3622790023
210UbiquitinationVSKVDDPKLANSEFL
HHHCCCHHHCCHHHH		68.1922790023
214 (in isoform 2)Phosphorylation-24.9023984901
217 (in isoform 2)Phosphorylation-3.5523984901
218 (in isoform 2)Phosphorylation-47.3223984901
218UbiquitinationLANSEFLKFVRQIGE
HCCHHHHHHHHHHCC		47.3222790023
280UbiquitinationQVEFERAKSAIESDV
EHHHHHHHHHHHCCC		46.7922790023
281PhosphorylationVEFERAKSAIESDVD
HHHHHHHHHHHCCCC		33.2325521595
285PhosphorylationRAKSAIESDVDFWDK
HHHHHHHCCCCHHHH		36.5025521595
302UbiquitinationAELEEMAKRDAEAHP
HHHHHHHHHHHHHCC		49.8822790023
312PhosphorylationAEAHPWLSDYDDLTS
HHHCCCCCCHHHHHH		30.2026525534
314PhosphorylationAHPWLSDYDDLTSAS
HCCCCCCHHHHHHCC		14.1625338131
318PhosphorylationLSDYDDLTSASYDKG
CCCHHHHHHCCCCCC		29.2825338131
319PhosphorylationSDYDDLTSASYDKGY
CCHHHHHHCCCCCCC		23.6325338131
427PhosphorylationLQRQACETLRDWLRY
HHHHHHHHHHHHHHH		27.29-
456UbiquitinationATGAGPSKRILGSLL
CCCCCCCHHHHHHHH		46.7422790023
527UbiquitinationNDYLMWNKLGATLAN
CCCCCHHHHCCEECC		32.55-
612PhosphorylationSTLRLALSMLGQSDA
HHHHHHHHHHCCCCC		13.3226643407
617PhosphorylationALSMLGQSDAYGAAD
HHHHHCCCCCCCCCC		23.5526643407
620PhosphorylationMLGQSDAYGAADARD
HHCCCCCCCCCCHHH		16.5826643407
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PEX5_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
11Cubiquitylation

-
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PEX5_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PEX5_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PEX5_MOUSE

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Related Literatures of Post-Translational Modification

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